HIV therapy

Question 1

Indinavir

Answer 1

protease inhibitor

Question 2

Fosamprenavir

Answer 2

protease inhibitor

Question 3

HAART

Answer 3

3 drugs: 2 NRTIs + 1 of the following… NNRTI or protease inhibitor or integrase inhibitor

Question 4

Lopinavir

Answer 4

protease inhibitor

Question 5

Zidovudine

Answer 5

NRTI used for general prophyl & during pregnancy to reduce risk of fetal transmission

Question 6

Emtricitabine

Answer 6

NRTI

Question 7

prevent maturation of new viruses by inhib HIV1 protease from cleaving polypeptide products of HIV mRNA into functional parts

Answer 7

Protease inhibitors

Question 8

Ritonavir

Answer 8

protease inhibitor- boosts other drug conc. by inhib cytochrome P450

Question 10

competitively inhib nucleotide binding to RT & terminate DNA chain (lacks 3’OH)
must be phosphorylated to be active

Answer 10

NRTIs

Question 11

Darunavir

Answer 11

protease inhibitor

Question 11

Didanosine

Answer 11

NRTI

Question 12

Saquinavir

Answer 12

protease inhibitor

Question 13

Lamivudine

Answer 13

NRTI

Question 14

Tenofovir

Answer 14

NRTI

Question 15

Abacavir

Answer 15

NRTI

Question 16

Stavudine

Answer 16

nucleotide reverse transcriptase inhibitor (does not require phosphorylation to be active)

Question 17

bind to RT at site different from NRTIs & do not require phosphorylation to be active or compete with nucleotides

Answer 17

NNRTIs

Question 18

Atazanavir

Answer 18

protease inhibitor

Question 19

Delavirdine

Answer 19

NNRTI

Question 20

Efavirenz

Answer 20

NNRTI

Question 21

Nevirapine

Answer 21

NNRTI

Question 22

inhib HIV genome integration into host cell chromosome by reversibly inhib HIV integrase

Answer 22

Integrase inhibitors

Question 23

Raltegravir

Answer 23

integrase inhibitor

Question 24

Enfuvirtide MOA

Answer 24

fusion inhibitor- binds gp41 to inhibit viral entry

Question 25

Maraviroc MOA

Answer 25

fusion inhibitor- binds CCR5 on surface of T cells/monocytes to inhib interaction with gp120