GI pharm

Question 1

cimetidine, ranitidine, famotidine, nizatidine

Answer 1

H2 blockers

Question 2

reversible block of H2 receptors - decr H+ secretion from parietal cells
use: peptic ulcer, gastritis, mild reflux

Answer 2

H2 blockers MOA

Question 3

omeprazole, lansoprazole, esomeprazole, pantoprazole, dexlansoprazole

Answer 3

PPI’s

Question 4

irrevers inhib H/K ATPase in stomach parietal cells

use: peptic ulcer, reflux, Zollinger Ellison

Answer 4

PPI’s MOA

Question 5

bind to ulcer base - give phys protection & allow HCO3- secretion to re-establish pH gradient in mucus layer
use: ulcer healing, traveler’s diarrhea

Answer 5

bismuth, sucralfate

Question 6

PGE1 analog, incr production & secretion of gastric mucus barrier, decr acid production
use: prevent NSAID peptic ulcers (NSAIDs block PGE1 production), maintain PDA, off label inducts labor (abortion)

Answer 6

Misoprostol

Question 7

long acting somatostatin analog, inhib actions of vasoactive intestinal peptide
use: acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors

Answer 7

Octreotide

Question 8

magnesium hydroxide, magnesium citrate, polyethylene glycol, lactulose

Answer 8

osmotic laxatives

Question 9

provide osmotic load to draw water into GI lumen

use: constipation, hepatic encephalopathy

Answer 9

osmotic laxatives MOA

lactulose treats hepatic encephalopathy

Question 10

combo of sulfapyridine abx + 5ASA anti inflam
activated by colonic bacteria
use: UC, Crohn’s

Answer 10

sulfasalazine

Question 11

5HT3 antagonist, lowers vagal stimul, powerful central acting anti emetic
use: post op vomiting, cancer chemo SE

Answer 11

ondansetron

Question 12

D2 receptor antagon, incr resting tone + contractility + LES tone + motility but NO influence on colon transit time
use: diabetic & post surg gastroparesis, anti emetic

Answer 12

Metoclopramide (pro motility)

Question 13

inhib gastric/pancreatic lipase - lowers breakdown & absorpt of dietary fats
use: wt loss

Answer 13

Orlistat