Musculoskel pharm

Question 1

reversibly inhib COX mostly in CNS, inactivated peripherally

use: anti pyretic, analgesic, NOT anti inflam

Answer 1

Acetaminophen

Question 2

a type of NSAID that irreversibly inhib COX1 & COX2 via acetylation - decr TXA2 & PG’s - incr bleeding time
use: low dose for decr platelet aggreg, intm dose as antipyretic & analgesic, high dose anti inflam

Answer 2

Aspirin

Question 3

reversibly inhib COX2 (in inflam cells & vascular endothel & mediates inflam & pain) but spares COX1 (maintains gastric mucosa)
spares platelet function b/c TXA2 depends on COX1
use: RA, OA

Answer 3

Celecoxib

Question 4

reversibly inhib COX1 & COX2 - block PG synthesis

use: anti pyretic, analgesic, anti inflam, close PDA

Answer 4

NSAIDs: ibuprofen, naproxen, indomethacin, ketorolac, diclofenac
indomethacin used to close PDA

Question 5

pyrophosphate analogs; bind hydroxyapatite in bone & inhib osteoclast activity - anti resorptive
use: osteoporosis, hypercalcemia, Paget disease of bone

Answer 5

bisphosphonates: alendronate, other -dronates

Question 6

recombinant PTH analog; given s.c. daily to increase osteoblast activity - incr bone growth
use: osteoporosis

Answer 6

Teriparatide

Question 7

inhib xanthine oxidase once converted to xanthine to inhib conversion to uric acid
use: chronic gout, tumor lysis syndrome

Answer 7

allopurinol

Question 8

inhib xanthine oxidase

use: chronic gout

Answer 8

febuxostat

Question 9

recombinant uricase catalyzes metabolism of uric acid to allantoin (more water soluble)
use: chronic gout

Answer 9

Pegloticase

Question 10

inhib reabsorption of uric acid in PCT as well as secretion of PCN; can precipitate uric acid calculi
use: chronic gout

Answer 10

Probenecid

Question 11

acute gout drugs

Answer 11

NSAIDs: naproxen, indomethacin
Glucocorticoids: oral or intra articular
colchicine: binds/stabilizes tubulin to inhib microtubule polymerization, impairs neutro chemotaxis & degranul

Question 12

fusion protein (receptor for TNF alpha + IgG1 Fc), produced by recombinant DNA; bind up TNAa so it's not overused in AI
use: RA, psoriasis, ankylosing spondylitis

Answer 12

TNF alpha inhibitor: etanercept

Question 13

anti TNFa MoAb

use: IBD, RA, ankylosing spondylitis, psoriasis

Answer 13

TNFa inhibitors: infliximab, adalimumab