Cholinomimetic agents

Question 1

direct ACh agonist

used for postop ileus, neurogenic ileus, urinary retention

Answer 1

Bethanechol

Question 2

direct ACh agonist

constricts pupil & relieves intraocular pressure in glaucoma

Answer 2

Carbachol

Question 3

direct ACh agonist

challenge test for asthma diagnosis

Answer 3

Methacholine

Question 4

direct ACh agonist
potent stimulator of sweat, tears, saliva
used for open angle & closed angle glaucoma

Answer 4

Pilocarpine

‘you cry, drool, sweat on your pilow’

Question 5

anti AChE

used for Alzheimer’s

Answer 5

Donepezil, Galantamine, Rivastigmine

Question 6

anti AChE

used for short acting diagnosis of MG (Tensilon test)

Answer 6

Edrophonium (Tensilon)

Question 7

anti AChE
used for postop & neurogenic ileus & urinary retention, MG, reversal of NM blockade post op
NO CNS penetration

Answer 7

Neostigmine

Question 8

anti AChE

used for anti cholinergic toxicity, crosses BBB

Answer 8

Physostigmine

‘PHYSostigmine phyxes atropine OD’

Question 9

anti AChE

used to tx MG (long acting), no CNS penetration

Answer 9

Pyridostigmine

‘pyRIDostiGMine gets RID of MG’

Question 10

irreversibly inhibits AChE — high levels of ACh

Answer 10

organophosphates (ie. parathion)