reproductive pharm

Question 1

GnRH analog with agonist props if pulsatile & antagon props if continuous (down regulates GnRH receptor in pituitary - decr FSH & LH)
use: infertility (pulsatile), prostate CA (continuous), uterine fibroids (contin), precocious puberty (contin)

Answer 1

leuprolide

Question 2

bind estrogen receptors
use: hypogonadism or ovarian failure, menstrual abnormalities, hormone replacement therapy in post menopause, men with androgen dependent prostate CA

Answer 2

estrogens: ethinyl estradiol, DES, mestranol

Question 3

selective estrogen receptor modulator- antagon at estrogen receptors in hypothal - prevents normal feedback inhib - incr release of LH & FSH from pituitary - ovulation
use: infertility d/t anovulation (PCOS)

Answer 3

clomiphene

Question 4

selective estrogen receptor modulator: antagon at breast, agon at bone & uterus
use: treat & prevent recurrence of ER/PR pos breast CA

Answer 4

tamoxifen

Question 5

selective estrogen receptor modulator: antagon at breast, & uterus, agonist at bone
use: tx osteoporosis

Answer 5

raloxifene

Question 6

aromatase inhibitors used in post menopause with ER pos breast cancer

Answer 6

Anastrozole/exemestane

Question 7

bind progesterone receptors, decr growth, incr vascularization of endometrium
use: in OCP’s & to tx endometrial cancer, abnormal uterine bleeding

Answer 7

progestins

Question 8

competitive inhib of progestins at progesterone receptors

use: terminate pregnancy, given with misoprostol PGE1

Answer 8

mifepristone

Question 9

estrogen & progestins inhib LH/FSH which prevents estrogen surge - no LH surge - no ovulation
progestins: thicken cervical mucus - limit access of sperm to uterus; inhib endometrial prolif - less suitable for implanting embryo

Answer 9

OCP’s: synthetic progestins, estrogen

Question 10

beta2 agonists that relax uterus, used to decr contraction frequency during labor

Answer 10

terbutaline, ritodrine

Question 11

synthetic androgen that acts as partial agonist at androgen receptors
use: endometriosis, hereditary angioedema

Answer 11

danazol

Question 12

agonists at androgen receptors

use: tx hypogonadism, promote 2’ develop of sex characteristics, stimul anabolism to promote recovery after burn/injury

Answer 12

testosterone, methyltestosterone

Question 13

anti androgen 5 alpha reductase inhibitor that decr conversion of testosterone to DHT
use: BPH, male pattern baldness

Answer 13

Finasteride

Question 14

anti androgen non steroid competitive inhib of androgen receptors
use: prostate carcinoma

Answer 14

flutamide

Question 15

anti androgen that inhib steroid synth via inhib 17,20 desmolase
use: PCOS, other
SE: gynecomastia, amenorrhea

Answer 15

ketoconazole

Question 16

anti androgen that inhib steroid binding, 17 alpha hydroxylase, and 17,20 desmolase
use: PCOS, other
SE: gynecomastia, amenorrhea

Answer 16

spironolactone

Question 17

alpha1 antagonist that inhib smooth m. contraction
selective for alpha 1A,D receptors on prostate
use: BPH

Answer 17

tamsulosin

Question 18

inhib PDE5 - incr cGMP & smooth m. relaxation in corpus cavernosum, incr blood flow, penile erection
use: ED

Answer 18

sildenafil, vardenafil, tadalafil

Question 19

direct arteriolar vasodilator

use: androgenetic alopecia, severe refractory HTN

Answer 19

minoxidil