Reproductive Endocrinology Flashcards
What is a simple neural reflex?
Nerves that release simple neurotransmitters directly onto the target tissue.
What is a neuroendocrine reflex?
Needs a neurohormone to enter blood and act at a remote location.
What is the neural control center for repro hormones?
Hypothalamus/pituitary
What organ deposits neurohormones directly into circulation?
Posterior pituitary
What regulates GnRH?
Male: Tonic center
Female: Tonic and Surge centers
What quantity of repro hormones do you need?
Small quanitities
How long are repro hormone half-lives?
Short
Where does GnRH come from?
Hypothalamic nuclei
Where do FSH, LH and prolactin come from?
Anterior Pituitary
Where does Oxytocin come from?
Posterior pituitary
Which repro hormones are a peptide?
GnRH
Which repro hormones are a glycoprotein?
FSH
LH
Inhibin
Which repro hormones are steroids?
Progesterone
Testosterone
Estradiol
What does PGF2a do?
Lyses the corpus luteum
What does PGE2 do?
Relaxes the cervix
How do protein hormones cause their actions?
Bind to plasma membrane bound receptors
How do steroid hormones cause their actions?
Travel freely through the plasma membrane into the cytoplasm and bind to the specific nuclear receptors
What does binding of hormones result in?
New protein synthesis
What are two functions of pheromones?
Influence the onset of puberty
Lets the male know who is in heat
What 4 things affect the strength of a hormone?
Pattern and duration of secretion
Half-life
Receptor density (this is really important)
Receptor-hormone affinity
NOTE: We can play with receptor-hormone affinity to make synthetic hormones that bind better than the natural hormone.
What are3 different patterns and duration of secretion?
Episodic
Basal
Sustained