Canine Pharmaceuticals Flashcards
Where should fresh semen be deposited in the dog?
Cranial vagina
What is a progestin that is approved for used in breeding bitches?
Ovaban (megestrol acetate)
What species can Ovaban (megestrol acetate) not be used in?
Why?
- Cats
- Can cause diabetes mellitus
What type of dosing is required with Ovaban (megestrol acetate)?
Daily dosing
When must Ovaban (megestrol acetate) be started by in order to be effective?
Must be started in first 3 days of proestrus to be effective.
When will the next estrous cycle start after the administration of Ovaban (megestrol acetate)?
4-6 weeks earlier
Other progesterones can predispose a dog to what 2 conditions?
- Cystic endometrial hyperplasia
- Pyometra
Progesterone needs to be in what concentration or lower range to consider supplementing?
3 ng/mL
What needs to be known in order to know when to stop supplementing?
When due to whelp
What can be used later in pregnancy that allows you to still measure P4 to see if hypoluteoidism is real or not?
Regumate (Altrenogest)
If supplementing with progesterone, ideally wait until what day?
Why?
- After 45 days of pregnancy (avoid 1st trimester)
- Avoid masculinization of female pups
When should progesterone supplementation be removed?
Why?
- 2-3 days prior to due date
- Allow cervix to relax adequately
What is an androgenic compound that prevents LH release by negative feedback, thereby preventing estrus?
Mibolerone
Mibolerone is contraindicated in what species?
Why?
- Cats
- Liver toxicity
Is Mibolerone approved for use in breeding bitches?
No
What type of dosing is required with Mibolerone?
Daily oral dosing
When does Mibolerone need to be started?
30 days prior to next anticipated cycle
What are 2 side effects that can be seen with the use of Mibolerone?
- Clitoral hypertrophy
- Vaginitis
Is Mibolerone recommended for use in breeding bitches?
No
When has mibolerone been used in bitches?
Used in bitches with short interestrus intervals
Mibolerone can help to achieve an IEI of what length?
At least 5 months
Before using mibolerone, make sure the bitch is not what?
Make sure not pregnant with baseline P4
What is a long acting implant (6-12 months) that down regulates the pituitary-gonadal axis?
Deslorelin (GnRH analogue)
What is a side effect that can be seen with “mismating” shots?
Pyometra
What is given in a “mismating” shot?
Estrogen
Estrogen toxicity can cause what in dogs and ferrets?
Bone marrow suppression
How frequently can an estrogen shot be given?
Not more than once every 30 days
What are 3 other options that can be used instead of “mismating” shots?
- Spaying once in diestrus
- Waiting until day 28-30 then abort pregnancy
- Allow whelping
Antiprotestins bind to what?
They have no effect on what?
- Bind to progesterone receptors
- No effect on progesterone
Aglepristone is an example of a what?
What can it be used for?
- Antiprogestin
- Early “mismating” shot
Multiple small in sections of prostaglandin will do what in the bitch or queen?
Lyse the CL
What are 5 possible side effects that can be seen with prostaglandins?
- Drop in blood pressure
- Vomiting
- Diarrhea
- Salivation
- Panting
What are 3 indications for the use of prostaglandin?
- Pyometra
- Retained placenta
- Mismating
- Collection of males
When is the best time to used prostaglandins?
During second trimester
What are 2 prolactin inhibitors?
- Bromocriptine
- Cabergoline
Which prolactin inhibitor is a dopamine agonist?
Bromocriptine
Which prolactin inhibitor is a serotonin antagonist?
Cabergoline
Prolactin is luteotropic in the bitch and queen during what trimester?
Second trimester
How is prolactin luteotropic?
CL will lyse in response to lowered prolactin levels.
