Repro Pharm Drills

Question 1

MOA of Terbutaline

Answer 1

• B-2 Agonist
• Used to relax the uterus; decrease contraction frequency
  (prevents premature labor)

Question 2

What do we used Ritodrine for?

Answer 2

• Stops premature labor
• Smooth muscle relaxant
• B2 agonist

Question 3

What drug inhibits the conversion of Testosterone to DHT?

Answer 3

Finasteride
- 5 alpha reductase inhibitor
SE: gynecomastia, decreased libido

Question 4

What drugs inhibit the conversion of testosterone to estrogen?

Answer 4

Aromatase inhibitors

Question 5

MOA of Exemestane

Answer 5

Aromatase Inhibitor
(only one that is not an azole)

Question 6

MOA of Degarelix

Answer 6

GnRH receptor antagonist
- treats prostate cancer
SE: hot flashes, liver toxicity

Question 7

MOA of mifepristone

Answer 7

Progesterone receptor inhibitor

Question 8

MOA of Misoprostol

Answer 8

PGE1 receptor analog

Question 9

Name 3 Tocolytics (stop premature labor)

Answer 9

• Terbutaline (B2 agonist)
• Indomethacin (NSAIDS)
• Nifedipine (Ca channel blockers)

Question 10

What electrolyte imbalance is caused by oxytocin?

Answer 10

HYPOnatremia

Question 11

MOA of Bicalutamide

Answer 11

• inhibitor of androgen receptor
• Used to treat prostate cancer

Question 12

What drug is a 17 alpha hydroxylase inhibitor?

Answer 12

Ketoconazole or Spironolactone

Question 13

MOA of anastrozole

Answer 13

Aromatase Inhibitor

Question 14

MOA of Letrozole

Answer 14

Aromatase Inhibitors

Question 15

MOA of Tamsulosin

Answer 15

Alpha receptor Blocker

Question 16

Drug of Choice for a pt with Male Pattern Baldness and BPH

Answer 16

• Finasteride (5 alpha reductase inhibitor)

Question 17

Drug of choice for a patient with Androgenetic alopecia and HTN

Answer 17

Minoxidil

Question 18

What is a hormone free, 99% effective contraception?

Answer 18

Copper IUD

Question 19

SE of Depo-Medroxyprogesterone (DMPA)?

Answer 19

Weight Gain

Question 20

What type of liver tumor is caused by OCPs?

Answer 20

Hepatocellular Adenoma

Question 21

MOA of Ulipristal

Answer 21

Competitive Inhibitor of progestins at progesterone receptors

Question 22

First Line of Treatment for Primary Dysmenorrhea?

Answer 22

OCPs

Question 23

SE of Tamoxifen

Answer 23

• hot flashes
• risk of DVTs
• endometrial Ca.

Question 24

What is the MOA of Tamsulosin?

Answer 24

Alpha 1 Blocker (in prostate)

Question 25

MOA of Buserelin

Answer 25

GnRH analog

Question 26

In what type for pregnancy do we use Methotrexate?

Answer 26

Ectopic Pregnancy

Question 27

What is Diesthelstibestrol (DES) associated with?

Answer 27

Vaginal Clear Cell Adenocarcinoma

Question 28

Patient with breast cancer is going through chemo, an asks for a contraception, what is the best contraception for this Pt?

Answer 28

Copper IUD (no hormones)

Question 29

What are the contraindications of a Progestin-IUD?

Answer 29

- Breast Cancer - Abnormal Menses - Uterine abnormalities - Active PID

Question 30

Contraindications in prescribing Ulipristal.

Answer 30

None! (unless you are pregnant and want to keep the baby)

Question 31

What are the contraindications of a Copper-IUD?

Answer 31

- Uterine anatomy abnormalities - Wilson’s Disease - Heavy Menses

Question 32

Side Effects of Raloxifene

Answer 32

- Increased Risk of DVTS - Hot flashes NO ENDOMETRIAL CANCER RISK

Question 33

MOA of Tamoxifen on the UTERUS

Answer 33

AGONIST - at bone and uterus ANTAGONIST - at breast

Question 34

Name all the drugs that causes gynecomastia.

Answer 34

Some - spironolactone Funny - finasteride Drugs - digitalis Cause - cimetidine Awesome - alcohol Knockers - ketoconazole

Question 35

What are the contraindications in prescribing OCPs?

Answer 35

- migraine with aura - history of breast cancer - DVTs - Smoker > 35 - HTN

Question 36

MOA of Leuprolide

Answer 36

GnRH agonist that inhibits LH and FSH (if given continuously)

Question 37

What is the 1st line treatment for PCOS patients for infertility?

Answer 37

Clomiphene - SERM (antagonist at estrogen receptors in hypothalamus)

Question 38

28 yr old pt who comes in with irregular menses for past six months and she is planning to conceive, physical exam, you notice there is facial hair and acne, she is 5ft tall and weight 168lbs, what is 1st line tx her symptoms?

Answer 38

Clomiphene

Question 39

Male pt comes inquiring about how to prevent gynecomastia, well built and he tells you he is taking steroids to bulk up, tx options?

Answer 39

- STOP TAKING STEROIDS - also aromatase inhibitor

Question 40

How do you prevent GBS neonatal sepsis in pregnant patients?

Answer 40

Intrapartum penicillin

Question 41

What do we use Tamsulosin to treat?

Answer 41

BPH

Question 42

Which hormone is anabolic and can help in burn injury patients help recover faster?

Answer 42

testosterone

Question 43

OCPs can increase the risk of what 2 cancers?

Answer 43

- ovarian cancer - endometrial cancers