Repro Pharm Drills Flashcards
MOA of Terbutaline
- B-2 Agonist
- Used to relax the uterus; decrease contraction frequency
(prevents premature labor)
What do we used Ritodrine for?
- Stops premature labor
- Smooth muscle relaxant
- B2 agonist
What drug inhibits the conversion of Testosterone to DHT?
Finasteride
- 5 alpha reductase inhibitor
SE: gynecomastia, decreased libido
What drugs inhibit the conversion of testosterone to estrogen?
Aromatase inhibitors
MOA of Exemestane
Aromatase Inhibitor
(only one that is not an azole)
MOA of Degarelix
GnRH receptor antagonist
- treats prostate cancer
SE: hot flashes, liver toxicity
MOA of mifepristone
Progesterone receptor inhibitor
MOA of Misoprostol
PGE1 receptor analog
Name 3 Tocolytics (stop premature labor)
- Terbutaline (B2 agonist)
- Indomethacin (NSAIDS)
- Nifedipine (Ca channel blockers)
What electrolyte imbalance is caused by oxytocin?
HYPOnatremia
MOA of Bicalutamide
- inhibitor of androgen receptor
- Used to treat prostate cancer
What drug is a 17 alpha hydroxylase inhibitor?
Ketoconazole or Spironolactone
MOA of anastrozole
Aromatase Inhibitor
MOA of Letrozole
Aromatase Inhibitors
MOA of Tamsulosin
Alpha receptor Blocker
Drug of Choice for a pt with Male Pattern Baldness and BPH
- Finasteride (5 alpha reductase inhibitor)
Drug of choice for a patient with Androgenetic alopecia and HTN
Minoxidil
What is a hormone free, 99% effective contraception?
Copper IUD
SE of Depo-Medroxyprogesterone (DMPA)?
Weight Gain
What type of liver tumor is caused by OCPs?
Hepatocellular Adenoma
MOA of Ulipristal
Competitive Inhibitor of progestins at progesterone receptors
First Line of Treatment for Primary Dysmenorrhea?
OCPs
SE of Tamoxifen
- hot flashes
- risk of DVTs
- endometrial Ca.
What is the MOA of Tamsulosin?
Alpha 1 Blocker (in prostate)
MOA of Buserelin
GnRH analog
In what type for pregnancy do we use Methotrexate?
Ectopic Pregnancy
What is Diesthelstibestrol (DES) associated with?
Vaginal Clear Cell Adenocarcinoma
Patient with breast cancer is going through chemo, an asks for a contraception, what is the best contraception for this Pt?
Copper IUD (no hormones)
What are the contraindications of a Progestin-IUD?
- Breast Cancer
- Abnormal Menses
- Uterine abnormalities
- Active PID
Contraindications in prescribing Ulipristal.
None! (unless you are pregnant and want to keep the baby)
What are the contraindications of a Copper-IUD?
- Uterine anatomy abnormalities
- Wilson’s Disease
- Heavy Menses
Side Effects of Raloxifene
- Increased Risk of DVTS
- Hot flashes
NO ENDOMETRIAL CANCER RISK
MOA of Tamoxifen on the UTERUS
AGONIST - at bone and uterus
ANTAGONIST - at breast
Name all the drugs that causes gynecomastia.
Some - spironolactone
Funny - finasteride
Drugs - digitalis
Cause - cimetidine
Awesome - alcohol
Knockers - ketoconazole
What are the contraindications in prescribing OCPs?
- migraine with aura
- history of breast cancer
- DVTs
- Smoker > 35
- HTN
MOA of Leuprolide
GnRH agonist that inhibits LH and FSH (if given continuously)
What is the 1st line treatment for PCOS patients for infertility?
Clomiphene
- SERM (antagonist at estrogen receptors in hypothalamus)
28 yr old pt who comes in with irregular menses for past six months and she is planning to conceive, physical exam, you notice there is facial hair and acne, she is 5ft tall and weight 168lbs, what is 1st line tx her symptoms?
Clomiphene
Male pt comes inquiring about how to prevent gynecomastia, well built and he tells you he is taking steroids to bulk up, tx options?
- STOP TAKING STEROIDS
- also aromatase inhibitor
How do you prevent GBS neonatal sepsis in pregnant patients?
Intrapartum penicillin
What do we use Tamsulosin to treat?
BPH
Which hormone is anabolic and can help in burn injury patients help recover faster?
testosterone
OCPs can increase the risk of what 2 cancers?
- ovarian cancer
- endometrial cancers
