- bladder cancer - lung ca. - kidney ca. - colon ca. - pancreatic ca. BLK CP (black cap)

- Neuroblastoma - Small Cell Lung Carcinoma

- Astrocytoma - Hepatocellular carcinoma

- Breast Cancer - Ovarian Cancer

- Neurofibromatosis Type 1 - Neuroblastomas

- FAP (familial adenomatous polyposis coli)

- Li-Fraumeni syndrome - majority of cancers

Onc Flashcards by ashley lovorn

RAS [blk cap]

bladder cancer
lung ca.
kidney ca.
colon ca.
pancreatic ca.

BLK CP (black cap)

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N-MYC

Neuroblastoma
Small Cell Lung Carcinoma

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ERB-B1

Squamous Cell Lung Carcinoma

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ERB-B2

Breast/Ovarian Cancer

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TGF-alpha

Astrocytoma
Hepatocellular carcinoma

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BCR-ABL

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BRCA-1 and BRCA-2

Breast Cancer
Ovarian Cancer

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NF-1

Neurofibromatosis Type 1
Neuroblastomas

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APC

FAP (familial adenomatous polyposis coli)

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DCC

colon cancer

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P53

Li-Fraumeni syndrome
majority of cancers

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retinoblastoma

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WT-1

Wilm’s Tumor

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Name the Oncology Med(s)
- decreases thymidine
(inhibits nucleotide synthesis)

Methotrexate
5-FU

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Name the Oncology Med(s)
- decreases purine synthesis
(inhibits nucleotide synthesis)

6-Mercaptopurine
(inhibited by xanthine oxidase)

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Name the Oncology Med(s)
- inhibits DNA cross linkage

alkylating agents
cisplatin

Name the Oncology Med(s)
- inhibits DNA intercalation
*can cause dilated cardiomyopathy

dactinomycin
doxorubicin

Name the Oncology Med(s)
- causes DNA strand breakage & inhibits DNA intercalation

Bleomycin

Name the Oncology Med(s)
- causes DNA strand breakage
(topoisomerase inhibitor)

Etoposide

Name the Oncology Med(s)
- inhibit microtubule formation

vincristine
vinblastine

Name the Oncology Med(s)
- inhibits microtubule disassembly

paclitaxel (taxanes)

SMX inhibits ____ _____

dihydroproteroate synthetase

TMP & Pyrimethamine & Methotrexate all inhibit ___ ____

dihydrofolate reductase

Quinolones inhibit ___ ___

DNA gyrase
- inhibits nicking and closing during DNA replication

Rifampin inhibits ___ ____ ____ ____

DNA dependent RNA polymerase

t(15;17); Auer Rods

AML/APML

t(9;22)

CML

TRAP +

Hairy cell leukemia

Smudge Cells (CD5)

CLL

t(8:14)

Burkitt's Lymphoma (C-MYC activation)

t(14:18)

Follicular Lymphoma (BCL-2 activation)

t(11;14)

Mantle Cell Lymphoma

t(11;22)

Ewing's Sarcoma

Name this Lymphoma - CD 30 + - CD 15 + - EBV related

Hodgkin's Lymphoma - B-cell origin - Reed Sternberg cells - EBV "owl's eyes"

Name this Neoplam - IL-6 + - HYPERcalcemia - Bence Jone Proteins in urine

Multiple Myeloma

Name this Neoplasm - excessive IgM antibody (M Spike) - headaches/vision problems - pain and numbness of extremities

Waldenstrom Macroglobulinemia