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Eagle Prep Review > Onc > Flashcards

Onc Flashcards

1
Q

RAS [blk cap]

A
  • bladder cancer
  • lung ca.
  • kidney ca.
  • colon ca.
  • pancreatic ca.

BLK CP (black cap)

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2
Q

N-MYC

A
  • Neuroblastoma
  • Small Cell Lung Carcinoma
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3
Q

ERB-B1

A

Squamous Cell Lung Carcinoma

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4
Q

ERB-B2

A

Breast/Ovarian Cancer

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5
Q

TGF-alpha

A
  • Astrocytoma
  • Hepatocellular carcinoma
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6
Q

BCR-ABL

A
  • CML
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7
Q

BRCA-1 and BRCA-2

A
  • Breast Cancer
  • Ovarian Cancer
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8
Q

NF-1

A
  • Neurofibromatosis Type 1
  • Neuroblastomas
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9
Q

APC

A
  • FAP (familial adenomatous polyposis coli)
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10
Q

DCC

A

colon cancer

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11
Q

P53

A
  • Li-Fraumeni syndrome
  • majority of cancers
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12
Q

RB

A
  • retinoblastoma
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13
Q

WT-1

A
  • Wilm’s Tumor
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14
Q

Name the Oncology Med(s)
- decreases thymidine
(inhibits nucleotide synthesis)

A
  • Methotrexate
  • 5-FU
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15
Q

Name the Oncology Med(s)
- decreases purine synthesis
(inhibits nucleotide synthesis)

A

6-Mercaptopurine
(inhibited by xanthine oxidase)

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16
Q

Name the Oncology Med(s)
- inhibits DNA cross linkage

A
  • alkylating agents
  • cisplatin
17
Q

Name the Oncology Med(s)
- inhibits DNA intercalation
*can cause dilated cardiomyopathy

A
  • dactinomycin
  • doxorubicin
18
Q

Name the Oncology Med(s)
- causes DNA strand breakage & inhibits DNA intercalation

19
Q

Name the Oncology Med(s)
- causes DNA strand breakage
(topoisomerase inhibitor)

20
Q

Name the Oncology Med(s)
- inhibit microtubule formation

A
  • vincristine
  • vinblastine
21
Q

Name the Oncology Med(s)
- inhibits microtubule disassembly

A

paclitaxel (taxanes)

22
Q

SMX inhibits ____ _____

A

dihydroproteroate synthetase

23
Q

TMP & Pyrimethamine & Methotrexate all inhibit ___ ____

A

dihydrofolate reductase

24
Q

Quinolones inhibit ___ ___

A

DNA gyrase
- inhibits nicking and closing during DNA replication

25
Q

Rifampin inhibits ___ ____ ____ ____

A

DNA dependent RNA polymerase

26
Q

t(15;17); Auer Rods

27
Q

t(9;22)

28
Q

TRAP +

A

Hairy cell leukemia

29
Q

Smudge Cells (CD5)

30
Q

t(8:14)

A

Burkitt’s Lymphoma (C-MYC activation)

31
Q

t(14:18)

A

Follicular Lymphoma (BCL-2 activation)

32
Q

t(11;14)

A

Mantle Cell Lymphoma

33
Q

t(11;22)

A

Ewing’s Sarcoma

34
Q

Name this Lymphoma
- CD 30 +
- CD 15 +
- EBV related

A

Hodgkin’s Lymphoma
- B-cell origin
- Reed Sternberg cells
- EBV “owl’s eyes”

35
Q

Name this Neoplam
- IL-6 +
- HYPERcalcemia
- Bence Jone Proteins in urine

A

Multiple Myeloma

36
Q

Name this Neoplasm
- excessive IgM antibody (M Spike)
- headaches/vision problems
- pain and numbness of extremities

A

Waldenstrom Macroglobulinemia

Eagle Prep Review (23 decks)

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