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Eagle Prep Review > Immuno Review > Flashcards

Immuno Review Flashcards

1
Q

Type of Rejection
- preformed recipient antibodies against graft antigens

A

Hyperacute

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2
Q

Type of Rejection
- gross mottling/cyanosis
- arterial fibrinoid necrosis & capillary thrombotic occlusion

A

Hyperacute
happens within minutes to hours

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3
Q

Type of Rejection
- exposure to donor antigens induces activation of naive immune cells (cell-mediated)

A

Acute
usually occurs w/in 6 months

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4
Q

Type of Rejection
- chronic low-grade immune response refractory to immunosuppression
- mixed cell mediated and humoral

A

Chronic Rejection
occurs months to years

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5
Q

Type of Rejection
- can cause obliterative vascular fibrosis

A

Chronic Rejection

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6
Q

Name the associated disorder that goes with this autoantibody:
- Antinuclear autoantibodies (ANA)

A

SLE

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7
Q

Name the associated disorder that goes with this autoantibody:
- Anti-ds DNA
- Anti-Smith

A

Specific for SLE

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8
Q

Name the associated disorder that goes with this autoantibody:
- Antihistone Antibodies

A

Drug-Induced Lupus

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9
Q

Name the associated disorder that goes with this autoantibody:
- Anticentromere

A

Scleroderma (CREST)

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10
Q

Name the associated disorder that goes with this autoantibody:
- Anti-Scl-70
- Anti-Topoisomerase I

A

Scleroderma (diffuse)

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11
Q

Name the associated disorder that goes with this autoantibody:
- Antimitochondrial

A

Primary biliary cholangitis

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12
Q

Name the associated disorder that goes with this autoantibody:
- Anti-Gliadin

A

Celiac Disease

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13
Q

Name the associated disorder that goes with this autoantibody:
- Anti- glomerular Basement Membrane

A

Goodpasture’s Syndrome
(Type II Hypersensitivity)

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14
Q

Name the associated disorder that goes with this autoantibody:
- Anti-desmoglein

A

Pemphigus vulgaris

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15
Q

Name the associated disorder that goes with this autoantibody:
- Anti-hemidesmosome

A

Bullous pemphigoid

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16
Q

Name the associated disorder that goes with this autoantibody:
- Anti-Ro/SSA
- Anti-La/SSB

A

Sjogren Syndrome

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17
Q

Name the associated disorder that goes with this autoantibody:
- Anti-Jo

A

Dermatomyositis
Polymyositis

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18
Q

Name the Cytokine
- secreted by macrophages
- acute inflammation

A

IL-1

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19
Q

Name the Cytokine
- Stimulates T cells

A

IL-2

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20
Q

Name the Cytokine
- stimulates Bone Marrow

A

IL-3

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21
Q

Name the Cytokine
- stimulates IgE, IgG production

A

IL-4

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22
Q

Name the Cytokine
- stimulates IgA production

A

IL-5

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23
Q

Name the Cytokine
- “reaction” fever

A

IL-6

24
Q

Name the Cytokine
- clears up infections
- recruits neutrophils

A

IL-8

25
Q

Name the Cytokine
- Anti-inflammatory

A

IL-10

26
Q

Name the Disorder (B cell vs. T cell)
- BTK gene defect
- no B cell maturation (agammaglobulinimia)
- failure to thrive

A

X-Linked (Bruton) Agammaglobulinimia

(B-cell Disorder)

27
Q

Name the Disorder (B cell vs. T cell)
- most common
- mucosal issue
- involved in celiac dz
- can cause false + B-hCG

A

Selective IgA deficiency

(B-Cell Disorder)

28
Q

Name the Disorder (B cell vs. T cell)
- older patients
- B cells present
- decrease IgM

A

Common Variable Immunodeficiency

(B-cell Disorder)

29
Q

Name the Disorder (B cell vs. T cell)
- 3rd and 4th branchial cleft development failure
- absent thyroid and parathyroid
- hypocalcemia

A

DiGeorge Syndrome (22q11 deletion)

  • CATCH

(T-cell Disorder)

30
Q

Name the Disorder (B cell vs. T cell)
- decrease TH1 response
- can present after BCG vaccine
- increased susceptibility to mycobacterium

A

IL-12 receptor deficiency

(T-cell Disorder)

31
Q

Name the Disorder (B cell vs. T cell)
- defects in AIRE
- causes candida (thrush/diaper rash)

A

Chronic Mucocutaneous Candidiasis

(T-cell Disorder)

32
Q

Name the Disorder (B cell vs. T cell)
- deficiency of TH17 due to STAT3 mutation
- decreased IFN-gamma

A

Hyper IgE (Job Syndrome)

ABCDEF’s (abscesses, baby teeth, coarse facies, derm issues, IgE, fractures)

(T-cell Disorder)

33
Q

Name the Disorder (B cell vs. T cell)
- defective IL-2R gamma chain
- ADA deficiency

A

SCID

(Both T and B cell disorder)

34
Q

Name the Disorder (B cell vs. T cell)
- defects in ATM gene
- failure to detect DNA damage
- Increased AFP
- Decreased IgA, IgG, and IgE

A

Ataxia - telangiectasisa

(Both T and B cell disorder)

35
Q

Name the Disorder (B cell vs. T cell)
- mutation in WAS gene
- causes thrombocytopenia, eczema, and recurrent infections

A

Wiskott-Aldrich Syndrome

(Both T and B cell disorder)

36
Q

Name the Disorder (B cell vs. T cell)
- defective CD40L on Th cells
- causes defective class switching

A

Hyper-IgM Syndrome

(Both T and B cell disorder)

37
Q

Name the Fungus
- Mississippi/Ohio River valleys
- Bird/Bat droppings
- Tiny Yeasts inside Macrophages

A

Histoplasmosis

38
Q

Name the Fungus
- Central America/East of MS river
- Broad, Based Budding
- can cause Granulomatous nodules

A

Blastomycosis

39
Q

Name the Fungus
- Southwestern US
- can cause pneumonia and meningitis

A

Coccidiomycosis

40
Q

Name the Fungus
- Latin America
- Captains Wheel Shape

A

Paracoccidiomycosis

41
Q

Name the Fungus
- Germ tube (diagnostic)
- can have pseudohyphae + budding yeasts
- can cause thrush

A

Candida Albicans

42
Q

Name the Fungus
- allergic bronchopulmonary aspergillosis
- “Fungus ball”
- mold with septate hyphae that branch at a V-shaped (45 degrees) angle

A

Aspergillosis

43
Q

Name the Fungus
- encapsulated yeast, not dimorphic
- pigeon droppings
- stains with india ink/latex agglutination test

A

Cryptococcus neoformans

44
Q

Name the Fungus
- irregular nonseptate hyphae branching at wide angles (> 90)
- infarction and necrosis of distal tissue

A

Mucormycosis

45
Q

Name the Disease
- gingivostomatitis
- keratoconjunctivitis
- temporal lobe encephalitis

A

HSV-1

46
Q

Name the Disease
- Herpes genitalis
- neonatal herpes
- Kaposi’s Sarcoma (HIV)

A

HSV-2

47
Q

Name the Disease
- Shingles
- Encephalitis

A

VZV

48
Q

Name the Disease
- Heterophile (+)
- infectious mononucleosis
- Burkitt’s Lymphoma

A

EBV

49
Q

Name the Disease
- congenital infection
- mononucleosis (monospot -)
- pneumonia
- “owl’s eye” cells

A

CMV

50
Q

Name the Disease
- Roseola
- exanthem subitum

A

HSV-6

51
Q

What cytokines are needed for granuloma formation?

A
  • IL-2
  • IF-gamma
  • TNF alpha
52
Q

Name the Hypersensitivity
- Mast Cell (Histamine)
- Basophils
- Atopic Dermatitis [Flare/Wheel]

A

Type I Hypersensitivity
(Anaphylaxis)

53
Q

Name the Hypersensitivity
- Cytotoxic - IgG/IgM
- Attack/Against Enemy activates MAC “Destroy)

A

Type II Hypersensitivity
(Cytotoxic)

54
Q

Name the Hypersensitivity
- Goodpasture’s
- ITP
- Graves Dz.
- Autoimune (RHO)
- Myasthenia Gravis

A

Type II

GIGAM

55
Q

Name the Hypersensitivity
- Deposits of Complex on Tissues or Blood Vessels
- Activated Complement consumed (decreased C3)

A

Type III Hypersensitivity
(Immune Complex)

56
Q

Name the Hypersensitivity
- Macrophages
- > 72 H
- T cell mediated

A

Type IV Hypersensitivity
(Delayed)

57
Q

Name the Hypersensitivity
- PPD
- TB
- Contact Dermatitis (Poison Ivy)

A

Type IV Hypersensitivity
(Delayed)

Eagle Prep Review (23 decks)

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