GI Pharm Drills Flashcards
What drug increases the risk of c. Diff and vibrio cholerae?
Omeprazole
What is the SE of cimetidine?
Can cause gynecomastia (anti-androgenic effects)
MOA: CYP450 inhibitor;
How does omeprazole increase the risk of fractures?
- irreversible H/K atpase pump inhibitor
- Decreased bivalent cation absorption-fractures in elderly
Most common drugs to cause gi ulcers/bleeds.
NSAIDS
What is the 1st line treatment for GERD?
PPI’s (omeprazole)
What do you tell a patient to avoid if you are planning to prescribe doxycycline for chlamydia?
No milk
Wear sunscreen
Don’t take an antacid
MOA of Orlistat
inhibits gastric and pancreatic lipase and is used for weight loss
SE of Orlistat
- Steatorrhea
- ADEK deficiency
- diarrhea
Treatment for actively bleeding esophageal varies?
- somatostatin/octreotide
Common side effects of Colchicine
- diarrhea
- nausea
What do we use alendronate to tx?
- osteoporosis
Initial treatment for Acute Gout Attack
NSAIDS
What are the two MOAs of colchicine?
- Inhibits microtubules
- Inhibits LTB4 (neutrophil chemotaxis)
Name a recombinant uricase that converts uric acid into allantoin.
Pegloticase (used for gout)
Name a xanthine oxidase inhibitor
allopurinol
What drugs cause DRUG induced LUPUS?
HIPPPE
- hydralazine
- isoniazide
- procainamide
- phenytoin
- penicillamine
- ethosuximide
What is the side effect of aluminum hydroxide?
Constipation
SE of magnesium hydroxide
- diarrhea
- hyporeflexia
- respiratory depression
What antibiotic can cause pyloric stenosis?
Erythromycin
Treatment options for C.diff
- oral vancomycin
- fidaxomicin (inhibits RNA polymerase)
Name the bulk forming laxatives that cause bloating
- psyllium
- methylcellulose
MOA of Lubiprostone
- treats chronic constipation
selectively stimulates Type II Cl- channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen
What drug causes melanosis coli?
- stimulant laxative (senna)
MOA of Diphenoxylate
Opioid receptor agonist (mu)
Which drug has the same clinical use as diphenoxylate and MOA?
Loperamide
What is the first line treatment for Ulcerative colitis?
sulfasalazine
