GI Pharm Drills

Question 1

What drug increases the risk of c. Diff and vibrio cholerae?

Answer 1

Omeprazole

Question 2

What is the SE of cimetidine?

Answer 2

Can cause gynecomastia (anti-androgenic effects)

MOA: CYP450 inhibitor;

Question 3

How does omeprazole increase the risk of fractures?

Answer 3

• irreversible H/K atpase pump inhibitor
• Decreased bivalent cation absorption-fractures in elderly

Question 4

Most common drugs to cause gi ulcers/bleeds.

Answer 4

NSAIDS

Question 5

What is the 1st line treatment for GERD?

Answer 5

PPI’s (omeprazole)

Question 6

What do you tell a patient to avoid if you are planning to prescribe doxycycline for chlamydia?

Answer 6

No milk
Wear sunscreen
Don’t take an antacid

Question 7

MOA of Orlistat

Answer 7

inhibits gastric and pancreatic lipase and is used for weight loss

Question 8

SE of Orlistat

Answer 8

• Steatorrhea
• ADEK deficiency
• diarrhea

Question 9

Treatment for actively bleeding esophageal varies?

Answer 9

• somatostatin/octreotide

Question 10

Common side effects of Colchicine

Answer 10

• diarrhea
• nausea

Question 11

What do we use alendronate to tx?

Answer 11

• osteoporosis

Question 12

Initial treatment for Acute Gout Attack

Answer 12

NSAIDS

Question 13

What are the two MOAs of colchicine?

Answer 13

• Inhibits microtubules
• Inhibits LTB4 (neutrophil chemotaxis)

Question 14

Name a recombinant uricase that converts uric acid into allantoin.

Answer 14

Pegloticase (used for gout)

Question 15

Name a xanthine oxidase inhibitor

Answer 15

allopurinol

Question 16

What drugs cause DRUG induced LUPUS?

Answer 16

HIPPPE
- hydralazine
- isoniazide
- procainamide
- phenytoin
- penicillamine
- ethosuximide

Question 17

What is the side effect of aluminum hydroxide?

Answer 17

Constipation

Question 18

SE of magnesium hydroxide

Answer 18

• diarrhea
• hyporeflexia
• respiratory depression

Question 19

What antibiotic can cause pyloric stenosis?

Answer 19

Erythromycin

Question 20

Treatment options for C.diff

Answer 20

• oral vancomycin
• fidaxomicin (inhibits RNA polymerase)

Question 21

Name the bulk forming laxatives that cause bloating

Answer 21

• psyllium
• methylcellulose

Question 22

MOA of Lubiprostone

Answer 22

• treats chronic constipation
  selectively stimulates Type II Cl- channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen

Question 23

What drug causes melanosis coli?

Answer 23

• stimulant laxative (senna)

Question 24

MOA of Diphenoxylate

Answer 24

Opioid receptor agonist (mu)

Question 25

Which drug has the same clinical use as diphenoxylate and MOA?

Answer 25

Loperamide

Question 26

What is the first line treatment for Ulcerative colitis?

Answer 26

sulfasalazine