Heme/Onc Pharm Drills Flashcards
MOA and SE of Busulfan
- Cross Links DNA
SE: myelosuppression, pulmonary fibrosis, hyperpigmentation (Busulfan Tan)
SE of Cisplatin
- Nephrotoxicity
- peripheral neuropathy (stock/glove)
- ototoxicity
How do you prevent hemorrhagic cystitis in patients taking cyclophosphamide?
- MESNA
- Hydration
SE of Doxorubicin
- dilated cardiomyopathy
- myelosuppression
- alopecia
What drug can you give to prevent dilated cardiomyopathy in those taking doxorubicin?
Dexrazoxane (iron chelating agent)
Treatment for ERBB-2 + Breast Cancer
Trastuzumab
SE: dilated cardiomyopathy
How do you prevent nephrotoxicity caused by carboplatin?
- Amifostine (free radical scavenger)
- Saline diuresis
Name the Topoisomerase II inhibitors
Etoposide
Teniposide
Name the Topoisomerase I inhibitors
- irinotecan
- topotecan
MOA of Methotrexate
folic acid analog that inhibits dihydrofolate reductase (DHR)
Name all the microtubule inhibitors (6)
Paclitaxel
Vincristine
Vinblastine
Colchicine
Griseofulvin
Albendazole
Name all the drugs that cause agranulocytosis (CCC DPPT)
Clozapine
Colchicine
Carbamazepine
Dapsone
PTU/Methimazole
Phenytoin
Ticlopidine
SE of Cyclosporine
Nephrotoxicity
HTN
Hyperlipidemia
Neurotoxicity
Gingival hyperplasia
Hirsutism
What is the drug of choice to treat CML?
Imatinib - tyrosine kinase inhibitor of BCR-ABL
Drug of choice to treat Hairy Cell Leukemia
Cladribine - purine analog
Pentostatin
CYP450 Inducers
Most Chronic alcoholics steal Phen-Phen and Never Refuse Greasy CarbS)
Most: Modafinil
Chronic alcoholics: Chronic alcohol use
Steal: St Johns Wort
Phen: Phenytoin
Phen: Phenobarbital
Never: Nevirapine
Refuse: Rifampin
Greasy: Griseofulvin
Carb: Carbamazepine/
Carbs: cyclophosphamide
CYP450 Inhibitors
SICKFAACES.COM/RG
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Acute alcohol abuse
Amiodarone
Chloramphenicol
Erythromycin/clarithromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
Ritonavir
Grapefruit Juice
CYP450 Dependent Drugs
WEPT-D
Warfarin
Estrogen/progesterone (OCPs)
Phenytoin (low dose)
Theophylline
Digoxin
What drug causes the development of IgG antibodies against platelet factor 4?
Heparin
Which heparin ONLY has activity against Factor Xa?
Fondaparinux
Which type of heparin is c/I in in a pt with high creatinine?
LMW heparin (has hepatic clearance)
What drug inhibits epoxide reductase?
Warfarin
What drug inhibits gamma carboxylation of vitamin K dependent factors?
Warfarin
What drug is a monoclonal antibody against GPIIb/IIIa?
Abciximab
How does warfarin cause hypercoagulability within the first few days?
- reduces protein C and protein S levels
What drug irreversibly inhibits cox 1 and 2 and inhibits platelet aggregation?
Aspirin
What drug inhibits P2Y12 ADP receptor required for platelet activation and crosslinking?
Clopidogrel
can be used instead of aspirin in patients with asthma or allergy
C/I in prescribing alteplase
- bleeding
- acute hypertension
Treatment for vWF deficiency
desmopressin
Prophylaxis and prevention for tumor lysis syndrome?
- IV hydration
- allopurinol/rasburicase
Treatment for Dabigatran overdose?
Idarucizumab
SE of Ticlopidine
Neutropenia
What drug directly in the converts plasminogen to plasmin, cleaving thrombin and fibrin clots?
- thrombolytics
(Alteplase, tPA)
