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Eagle Prep Review > Heme/Onc Pharm Drills > Flashcards

Heme/Onc Pharm Drills Flashcards

1
Q

MOA and SE of Busulfan

A
  • Cross Links DNA
    SE: myelosuppression, pulmonary fibrosis, hyperpigmentation (Busulfan Tan)
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2
Q

SE of Cisplatin

A
  • Nephrotoxicity
  • peripheral neuropathy (stock/glove)
  • ototoxicity
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3
Q

How do you prevent hemorrhagic cystitis in patients taking cyclophosphamide?

A
  • MESNA
  • Hydration
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4
Q

SE of Doxorubicin

A
  • dilated cardiomyopathy
  • myelosuppression
  • alopecia
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5
Q

What drug can you give to prevent dilated cardiomyopathy in those taking doxorubicin?

A

Dexrazoxane (iron chelating agent)

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6
Q

Treatment for ERBB-2 + Breast Cancer

A

Trastuzumab
SE: dilated cardiomyopathy

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7
Q

How do you prevent nephrotoxicity caused by carboplatin?

A
  • Amifostine (free radical scavenger)
  • Saline diuresis
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8
Q

Name the Topoisomerase II inhibitors

A

Etoposide
Teniposide

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9
Q

Name the Topoisomerase I inhibitors

A
  • irinotecan
  • topotecan
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10
Q

MOA of Methotrexate

A

folic acid analog that inhibits dihydrofolate reductase (DHR)

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11
Q

Name all the microtubule inhibitors (6)

A

Paclitaxel
Vincristine
Vinblastine
Colchicine
Griseofulvin
Albendazole

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12
Q

Name all the drugs that cause agranulocytosis (CCC DPPT)

A

Clozapine
Colchicine
Carbamazepine
Dapsone
PTU/Methimazole
Phenytoin
Ticlopidine

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13
Q

SE of Cyclosporine

A

Nephrotoxicity
HTN
Hyperlipidemia
Neurotoxicity
Gingival hyperplasia
Hirsutism

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14
Q

What is the drug of choice to treat CML?

A

Imatinib - tyrosine kinase inhibitor of BCR-ABL

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15
Q

Drug of choice to treat Hairy Cell Leukemia

A

Cladribine - purine analog
Pentostatin

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16
Q

CYP450 Inducers

A

Most Chronic alcoholics steal Phen-Phen and Never Refuse Greasy CarbS)

Most: Modafinil
Chronic alcoholics: Chronic alcohol use
Steal: St Johns Wort
Phen: Phenytoin
Phen: Phenobarbital
Never: Nevirapine
Refuse: Rifampin
Greasy: Griseofulvin
Carb: Carbamazepine/
Carbs: cyclophosphamide

17
Q

CYP450 Inhibitors

A

SICKFAACES.COM/RG

Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Acute alcohol abuse
Amiodarone
Chloramphenicol
Erythromycin/clarithromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
Ritonavir
Grapefruit Juice

18
Q

CYP450 Dependent Drugs

A

WEPT-D

Warfarin
Estrogen/progesterone (OCPs)
Phenytoin (low dose)
Theophylline
Digoxin

19
Q

What drug causes the development of IgG antibodies against platelet factor 4?

A

Heparin

20
Q

Which heparin ONLY has activity against Factor Xa?

A

Fondaparinux

21
Q

Which type of heparin is c/I in in a pt with high creatinine?

A

LMW heparin (has hepatic clearance)

22
Q

What drug inhibits epoxide reductase?

A

Warfarin

23
Q

What drug inhibits gamma carboxylation of vitamin K dependent factors?

A

Warfarin

24
Q

What drug is a monoclonal antibody against GPIIb/IIIa?

A

Abciximab

25
Q

How does warfarin cause hypercoagulability within the first few days?

A
  • reduces protein C and protein S levels
26
Q

What drug irreversibly inhibits cox 1 and 2 and inhibits platelet aggregation?

A

Aspirin

27
Q

What drug inhibits P2Y12 ADP receptor required for platelet activation and crosslinking?

A

Clopidogrel

can be used instead of aspirin in patients with asthma or allergy

28
Q

C/I in prescribing alteplase

A
  • bleeding
  • acute hypertension
29
Q

Treatment for vWF deficiency

A

desmopressin

30
Q

Prophylaxis and prevention for tumor lysis syndrome?

A
  • IV hydration
  • allopurinol/rasburicase
31
Q

Treatment for Dabigatran overdose?

A

Idarucizumab

32
Q

SE of Ticlopidine

A

Neutropenia

33
Q

What drug directly in the converts plasminogen to plasmin, cleaving thrombin and fibrin clots?

A
  • thrombolytics
    (Alteplase, tPA)

Eagle Prep Review (23 decks)

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