Antibiotics + Misc. Drugs Flashcards

1
Q

What drugs bind to trans peptides’ e-binding protein and inhibits transpeptidase cross-linking of the peptidoglycan on the cell wall?

A
  • Penicillins
  • Cephalosporins
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2
Q

What drug binds to penicillin-binding protein 3 and inhibits peptidoglycan cross-linking?

A
  • Beta - lactams (aztreonam)
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3
Q

What drug inhibits the cell wall peptidoglycan formation by binding to D-ala-D-ala?

A

Vancomycin

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4
Q

What drug inhibits the initiation complex by binding to 30s subunit?

A
  • Aminoglycosides
  • Tetracyclines
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5
Q

What drug inhibits the initiation complex by binding to 50s subunit?

A

Linezolid

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6
Q

What drug inhibits peptidyl transferase by binding to 50s Subunit?

A

Chloramphenicol

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7
Q

What drug inhibits peptide transfer by binding to 50s subunit?

A

Clindamycin

meaning it inhibits translocation

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8
Q

What drug prevents the attachment of aminoacyl tRNA?

A

Tetracyclines

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9
Q

What drug binds to 23s rRNA of the 50S subunit and inhibits protein synthesis?

A

Macrolides

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10
Q

What two antibiotics bind to cell membranes and cause cell membrane disintegrity?

A
  • Daptomycin
  • Polymyxins
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11
Q

Anti fungal that binds to ergosterol and causes cell membrane disintegrity?

A

Amphotericin B

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12
Q

Which antibiotic damages DNA by forming free radicals?

A

Metronidazole

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13
Q

Which antibiotic is a partial monoamine oxidase inhibitor?

A

Linezolid

can cause Serotonin Syndrome

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14
Q

Which antibiotic inhibits dihydropteroate synthase and inhibits folic acid synthesis?

A

Sulfonamides (SMX, Dapsone)

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15
Q

Which antibiotic inhibits dihydrofolate reductase?

A

TMP

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16
Q

Reversal drug for Dapsone Toxicity

A

Methylene Blue

17
Q

Which antibiotic inhibits arabinosyltransferase?

A

Ethambutol

18
Q

What is a side effect of ethambutol?

A

optic neuritis

19
Q

What drug inhibits DNA-dependent RNA polymerase?

A

Rifampin

20
Q

What antibiotic can cause red/orange secretions and hepatotoxicity?

A

Rifampin

21
Q

Which antibiotic is activated by KatG?

A

Isoniazid

22
Q

What is a major side effect of Isoniazid?

A

Drug-Induced Lupus

(HIPPE - drug induced lupus drugs)

23
Q

Which antifungal agent inhibits the conversion of Lanosterol to ergosterol?

A
  • azoles
24
Q

What antifungal agent inhibits squalene epoxidase?

A

Terbinafine

25
Q

Which antifungal inhibits microtubule polymerization?

A

Griseofulvin

26
Q

Which antifungal agent inhibits DNA and RNA synthesis?

A

Flucytosine

27
Q

MOA of Mebendazole

A

Microtubule inhibitor

28
Q

Which antifungal agent is a cell wall inhibitor?

A

Caspofungin

29
Q

What drugs inhibit viral DNA polymerase and causes DNA chain termination?

A
  • Acyclovir
  • Ganciclovir
  • Cidofovir
30
Q

What drug inhibits the interaction with gp120?

A

Maraviroc

31
Q

What drug binds to gp41 and inhibits fusion of the HIV virus?

A

Enfuviritide

32
Q

What is a SE of acyclovir?

A

crystalline nephropathy

33
Q

MOA of Raltegravir

A

HIV integrase Inhibitor