Repro DZ Flashcards
Baby born with renal damage. Mother on what drug?
ACE inhibitor
Baby born without fingers. Mother on what drug?
Alkylating agent
Baby born with cranial nerve 8 toxicity (ototixicity). Mother took what drug?
Aminoglycosides
Baby born with neural tube defects, craniofacial defects, fingernail hypoplasia. Mother taking what drug?
Carbamazepine
Baby born with vaginal clear cell carcinoma and congenital Mullarian anomalies. Mother on what drug?
Diethylstilbestrol
Baby born with atrialized right ventricle. What drug was mother taking
Li
Baby born with microcephaly, cardiac defects, craniofacial defects, hypoplastic nails, and mental retardation. What drug was mother taking?
Phenytoin
Baby born with flipper limbs. What drug was mother taking
Thalidomide
Drugs that can cause neural tube defects?
Valproate, carbamazepine, alcohol folate antagonists
Baby born with bone deformities, fetal hemorrhage, and ophthalmologic abnormalities. What drug was mother taking?
Warfarin
Drug that could lead to placental abruption?
Cocaine
Drug that can lead to preterm labor, placental problems and ADHD?
Cigarettes
Maternal diabetes can lead to what embryological defect?
Anal atresia, transposition of great vessels, neural tube defects, Polyhydramnios
Vitamin that can lead to spontaneous abortions and birth defects?
Vitamin A
While pregnant, mother gets x-rays. Effect on child?
Microcephaly, mental retardation
Newborn presents with mental retardation, facial abnormalities, limb dislocation, and heart and lung fistulas. Mother was taking what drug?
Alcohol
Tall male with gynecomastia presents for infertility workup. Lab findings?
Klinefelter syndrome. Decreased inhibin and decreased testosterone
Patient presents with horseshoe kidney and short stature
Turner syndrome
Patient presents with severe acne and antisocial behavior. Very tall. Fertility?
Double Y males. Normal fertility
Primary hypogonadism versus Hypogonadotrophic hypogonadism
Problem in testis versus problem in brain
Patient with female external genitals but with internal testes. most common cause?
Androgen insensitivity syndrome
Patient with ovaries but male external genitalia. Cause?
Congenital adrenal hyperplasia or exogenous administration of androgens during pregnancy
Female patient presents with amenorrhea, fully developed secondary sexual characteristics, normal height and weight.
Malaria agenesis or imperforate hymen
Patient with normal female genitalia. no uterus or Fallopian tubes. Increase testosterone estrogen and LH
Androgen insensitivity syndrome
Patient with ambiguous genitalia until puberty
5a-reductase deficiency
Patient presents with no secondary sexual characteristics and can’t smell.
Kallmann syndrome. Defective migration of GnRH cells and formation of olfactory bulb
Snowstorm appearance on sonogram. Genetics?
Complete mole. 46 XX, 46XY
Treatment of hydatidiform moles.
Methotrexate and D/C
Increased beta hCG with what type of mole
Complete mole
Five year old child with grape like mass protruding from genitals. Stain with?
Embryo rhabdomyosarcoma. Stains positive for Desmin And myoglobin.
Patient comes in with jaundice elevated liver enzymes and low platelets.
HELLP syndrome.
Patient with the eclampsia death by? Tx?
Cerebral hemorrhage and ARDS. Magnesium sulfate
Patient presents with painful bleeding in third trimester. Risk factors?
Placental abruption
Smoking
hypertension
cocaine use
Patient has massive bleeding after delivery
Placenta accreta
Patient comes in with recurrent first trimester abortions
Robertsonian translocations
Patient comes in with the attachment of placenta to the lower uterine segment. Risk factors?
Multiparity and prior C-section
Most common cause of polyhydramnios?
Esophageal or duodenal atresia
Causes of oligohydramnios
Placental insufficiency
bilateral renal agenesis
Posterior urethral valve problems
Patient with HPV. Gets dysplasia carcinoma in situ. What genes caused this?
E6 - inhibits p53
E7 - inhibits RB
Female patient presents with renal failure. Koilocytes are found in cervix.
Invasive carcinoma
Patient with retained products of conception following delivery. Treat with?
Endometritis. Gentamicin and clindamycin
Acute endometritis versus chronic endometritis
Fever, bleeding, pain
Vs
Plasma cells, PID, infertility
Patient with severe menstrual pain, painful intercourse, presents for infertility. Treatment?
Endometriosis. OCP, NSAIDs, leuprolide, danazol