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2nd Time Through > Immuno/Path Dzs > Flashcards

Immuno/Path Dzs Flashcards

1
Q

Pt with. C1 esterase deficiency. PD will find? Mech?

A

Hereditary angioedema. Increased kalkerin activation - increased bradykinin - increased vasodilation

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2
Q

Pt with recurrent pyogenic sinus and respiratory tract infections. Increased susceptibility to type III hypersensitivity reactions?

A

C3 deficiency

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3
Q

Recurrent Neisseria infections - immune defect?

A

C5-C9 (no mac complex)

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4
Q

With with occasional hemolobinuria. Possible immune defect?

A

Paroxysmal nocturnal Hb-uria. Deficiency in DAF

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5
Q

Pt with fever, urticaria, arthralgias, and proteinuria a week after exposure to drug?

A

Serum sickness. HSR III

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6
Q

Intredermal injection of vaccine. Get edema, necrosis and complement activation in that area?

A

Arthus reaction

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7
Q

Pt given blood. Gets urticaria, wheezing and fever? tx?

A

Type I HSR. Give antihistamines

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8
Q

PT given blood. Has trouble breathing, hypotension and goes into shock.

A

Anaplylaxis. IgA deficient pt got blood with IgA

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9
Q

Pt given blood.Gets fever, headaches, chills and flushing

A

HSR II (host Abs against donor HLAs)

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10
Q

Pt given blood. fever, hypotension, increased HR, increased RR, flank pain and jaundice

A

HSR II. Intravascular hemolysis (wrong blood group)

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11
Q

Pt with recurrent bacterial infections after 6 months of age. Defect?

A

X-linked Bruton’s agammaglobuliemia.

BTK gene, no B-cell maturation

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12
Q

Pt with recurrent sinusitis and pulmonary infections and numerous allergies. Also has milk allergies and diarrhea.

A

Selective IgA deficiency. (decreased IgA leads to respiratory infections and GI infections)

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13
Q

young adult patient with numberous sinopulmonary infections. Has Lupus. Normal B cells but low plasma cells? Risk for?

A

Common variable immunodefiency. Lymphoma

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14
Q

Pt with small lymph nodes, decreased B-cells and low IgGs. Defect?

A

X-linked Bruton’s agammaglobuliemia.

BTK gene, no B-cell maturation

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15
Q

Female pt with recurrent sinusitis and pulmonary infections and numerous allergies. Has positive B-HCG but not pregnant. Cause?

A

Selective IgA deficiency.

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16
Q

Pt with tetany and recurrent viral/fungal infections. No thymic shadow. Dx?

A

DeGeorges

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17
Q

Pt with recurrent dessemminated infections. Labs show?

A

decreased INF-y. IL-12 receptor deficiency (few Th1s)

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18
Q

Pt with course facial features, rash and non-inflammed abcesses.

A

Hyper-IgE (Jobs).

19
Q

Hyper IgE - findings?

A 
FATED
course Facies
noninflammed staph Abcesses
retained primary Teeth
increaed IgE
Derm findings (ezcema)
20
Q

Pt with chronic Candida infections. Low IL-2 and INF-y. Defect?

A

Chronic mucocutaneous candidiases

21
Q

Young pt with chronic diarrhea. Bacterial, fungal and viral infections. Absent thymic shadow.

A

SCID (no T or B cells)

22
Q

Pt with increased AFP and decreased IgA, IgG and IgE. Defect?

A

Ataxia-telangiectasia. ATM gene mutation, bad repair.

23
Q

Pt with bad balance, spider angiomas, and multiple respiratory infections. Defect?

A

Ataxia-telangiectasia. ATM gene mutation, bad repair.

24
Q

Pt multiple pyogenic infections. Decreased neutrophils, decreased IgA, IgG and IgE. Defect?

A

Hyper IgM. CD40L defect (can’t class switch)

25
Q

Pt with low platelets, rash and multiple infections.Labs will show? Defect?

A

Wiskott-Aldrich. WASP gene (T-cell cytoskeleton defect)

26
Q

Pt with Increased IgE, IgA, decreased IgM. Defect?

A

Wiskott-Aldrich.

27
Q

Defect in LFA-1 integrin, CD18

A

Leukocyte adhesion deficiency

28
Q

Pt with recurrent bacterial infections. No pus.

A

Leukocyte adhesion deficiency

29
Q

Pt who’s umbilical cord took a long time to come off?

A

Leukocyte adhesion deficiency

30
Q

Giant granules in neutrophils.

A

Chediack-Higashi

31
Q

Organ transplant. Organ becomes cyanotic and mottled almost instantly? Leads to?

A

Hyperacute rejection. HSR II. Leads to ischemia and necrosis

32
Q

Organ transplant. Pt becomes sick a few weeks later? Histo?

A

Acute rejection. Vasculitis with interstitial lymphocytic infiltrate.

33
Q

Organ transplant. Pt becomes sick a few months later? Histo?

A

Chronic. Obliterative vascular fibrosis. HYPOCELLULAR. irreversible.

34
Q

Organ transplant. Pt comes in with maculopapular rash, jaundice, hepatosplenomegaly, and diarrhea.

A

Graft vs Host.

35
Q

Pt with chronic renal failure presents with carpal tunnel and joint pain. Dz?

A

B2-microgobulin amyloid. Seen in dialysis pts.

36
Q

Heriditary amyloid that affects heart and brain?

A

ATTR

37
Q

Cause of amyloid if found in:

1) heart
2) thyroid
3) pancreas
4) brain
5) pituitary

A 
1-ANP
2-Calcitonin
3-Islet amyloid protein
4-B-amyloid (APP)
5-Prolactin
38
Q

Most common benign tumor in male/female?

A

lipoma/leiomyoma

39
Q

Movable mass at angle of jaw?

A

mixed tumor

40
Q

Female with RLQ pain with radiographic calcifications?

A

tertatoma with teeth

41
Q

Pt with Tuberous sclerosis - increased risk of what cancer?

A

Giant cell astrocytoma
renal angiomyolipoma
Cardiac rhabdomyoma

42
Q

Bombesin - marker for?

A

Neutroblastoma
Lung cancer
Gastric cancer

43
Q

hyperacute vs acute rejections - main cells?

A

Abs (B-cells) vs CTL (T-cells)

44
Q

Pt has disease with a failure for Th1 to produce INF-y vs failure of Th1 to respond.

A

Hyper-IgE vs IL-12 deficiency

2nd Time Through (23 decks)

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