Immuno Flashcards
Lymph node - dense follicle vs follicles with pale central pallor?
inactive (primary) vs active (secondary)
lymph node Medulla - parts and function?
1) cords - plasma cells
2) Sinuses - macrophages
Part of lymph node not well developed in DiGeorge syndrome?
ParaCTX (t-cells)
Speen - location of T vs B cell?
Periarterial vs follicles in white pulp
Splenic dysfuntion - susceptible to? Why?
decreased IgM decreases complement activation and opsonization; increased susceptability to Encapsulated organisms -
SHiNE SKiS
strep pneumo, h flu, neisseria, Ecoli, salmonella, klebsiella,
Thymus - negative vs positive selection?
center (mature cells) vs periphery (immature cells)
Embryological origin of thymus vs lympocytes?
3rd brachial pouch vs mesenchyme
RBCs - how to kill infected cells?
NK cells. No MHC so no cytotoxicresponse
MHC I receptor consists of?
a peptide (for binding) B2 microglobulin
MHCII only present on what cells?
APCs
HLA: A3
Hemochromatosis
HLA: DR2
MS, hay fever, SLE
HLA: DR3
DM 1, graves
HLA: DR4
DM 1, RA
HLA: DR5
Hashimotos and pernicious anemia
Only lymphocyte member of innate immune response? Activity enhanced by?
NK cells. IL-2, IL-12, IFN-B, IFN-a
T helper cell induced by?
IL-12 to become Th1
IL-4 to become Th2
TLRs on what cells? bind to? Activation triggers?
Macrophages and DCs; PAMPS; release of NFkB which increases acute inflam response genes
T cell receptor complex?
TLR and CD3
Only APC to activate naive T-cell?
DC
Necessary signals for T activation vs B-cell activation?
1) MHC I presentation by DC
2) B7 and CD28 costimulatory signal
vs
1) MHC II presentation by CD4 cell
2) CD40-CD40 costimulatory signal
B-cells class switching determined by?
Cytokines released by Th cell
Th1 vs Th2
1 secretion of?
2 Activates?
3 Inhibited by?
1 IFN-y vs IL-4,5,10,13
2 Macrophages/CD8 vs Esosinophils and IgE production
3 IL4,5 vs IFN-y
How do macrophages and lympcytes stimulate one another?
Macrophage releases IL-1, TNF-a
Lymhpocytes release INF-y
CD8 kills by?
Releasing perforin and granzyme
CD3, CD4, CD25 cell. funtion?
regulatory T-cell. Decrease response. Secrete IL-10 and TGF-B
Complement binds to what Igs?
IgM and IgG
Fc portion - describe
Constant, Carboxy terminal, Complement binding, Carbohydrate side chains