Cardiac Flashcards
Fetal Erythopoiesis from where/when?
Yolk sac - 3-10 weeks
Liver 6wks -birth
Spleen 15-30 wks (liver does most)
Bone marrow 22 wk to adult
Pathway of blood in fetus?
Syncytiotrophoblasts to cytotrophoblasts to stroma of chorionic villus, umbilical vein to liver
Which papillary muscle may rupture post MI?
One fed by RCA
Most resistance in what vessels?
arterioles
2 Formulas for CO?
see 253
2 Formulas for MAP?
see 253
Acidosis - affect on contractility?
decreases
Myocardial O2 demand increased by?
increased afterload
increased contractility
increased HR
increased heart size
Normal ejection fraction?
55%
increased blood viscosity with?
polycythemia, hyperproteinemic states, hereditary spherocytosis
Exercise - effect on lymph flow?
increased flow during exercise - increased hydrostatic pressure - increased capillary filtration - increased lymph flow
HCM murur - loudest when?
Effect of: handgrip, valsalva, squatting
When less blood in LV.
decreased, increased, decreased
MVP - is “click” closest to S1 or S2:
Increased preload
Decreased preload
Anxious
S2, S1, S1
click happens when at a certain LV volume (more blood means more time before it hits that level of empty). Anxiety increases HR, decreasing preload.
heart Valves - type of tissue?
connective tissue
S3 murmur suggests? normal in what pts?
Mitral Regurg
children and pregnant women
S4 suggests?
LV hypertrophy
Pt with sycope, angina and dyspena. Heart murmur?
AS
Holosystolic murmur loudest at tricuspid area? Made louder with?
VSD. Handgrip
Mumur heard best when leaning forward?
AR.
Mech of SNS increasing HR?
increased opening of funny current in cardiac pacemakers.
U wave caused by?
HypoK and bradycardia
Order of signal transduction in heart? (speed?)
SA Atria (2) AV (4) Bundle of His Purkinje (1) Ventricles (3)
(1 = fastest)
Pt with defects in cardiac Na/K pumps and congenital sensorineural deafness?
Jervell and Lange-Nielsen syndrome. Congenital long QT syndrome.
Aortic arch receptors vs carotid sinus receptors (responds to/nerve)
Increased BP via vagus nerve
vs
Increased and decreased BP via CN9
ANP - functions?
constricts EA and dilates AA
1st vs 2nd (type I) vs 2nd (type II) vs 3rd heart block
long PR vs increasing PR until dropped P vs Randomly dropped QRS vs random P and QRS complexes
Increased BaroR caused by? leads to?
increased pressure. Increased PSNS (and decreased SNS) to lower heart rate, contractility (point of Carotid massage)
Central vs peripheral chemoreceptors?
stimulated by CO2 vs O2
Circulation
1) largest share of cardiac output?
2) Higher blood flow per gram of tissue?
3) Organ with largest extraction of O2?
1 - liver
2 - kidney
3 - heart
Causes of early cyanosis?
Right to Left shunts: Tetrology Transposition Truncus arteriosus Tricuspid atresia (if with ASD and VSD) TAPVR
Congenital Causes of adult cyanosis.
ASD, VSD, PDA. Cause cyanosis after switching to become R-to-L shunts
Boot Shaped heart on x-ray?
Tetralogy of fallot
Infantile vs adult coarcation
before vs after ductus arteriosis
Xanthomas - histo?
Multinucleated giant cells with lipids
Corneal arcus?
Lipids in eyes
Califications in blood vessels in this location does no affect blood flow?
Media
Pt with DM. Likely will get disease of what vessels?
Arterioloes
Arteriolosclerosis - types?
Hyaline - HTN/DM
Hyperplastic - Onion skinning
Pt with plaques in vessels. Affects what vessels?
Atherosclerosis. Arteries
Most common location of atherosclerosis? Complication?
abdominal aorta. Abdominal aneurysm
Thoracic aortic aneurysm - causes?
Marfans
HTN
Syphilis
Myocardial stunning?
gradual regaining of function post MI
MI as cells lose energy form ishemia they release this to vasodilate. Where does it come from?
ATP - ADP - AMP - Adenosine (dilates)
Evolution of MI
time points: 0, 4, 12, 24, 4, 12
see 271
Pathologic Q waves?
transmural infarct
Tropoinin vs CKMB
peaks in 4 hours and stays elevated vs peaks in a day and dips
MI, what can rupture (leads to?)
1) free wall - cardiac tamponade
2) papillary muscle - Mitral Regurg
3) Interventricular septum rupture - VSD
Ventricular aneurysm - cause lead to?
arrythmia or CHF. Will not rupture
Causes of high output cardiac failure?
Thiamine deficiency
Graves dz
AV-fistula
Pagents dz
Bacteria involved? Endocarditis vs Rheumatic fever
growth on values vs no bacteria on valves
Pt with thick, calcified leaflets on mitral valves. Hx may show?
Rheumatic fever
SIgns of Bacterial Endocarditis?
FROM JANE
Fever, roth spots, oslers, nodes, murmur, janeway lesions, anemia, nail hemorrage, emboli
Signs on rheumatic fever?
FEVERSS
fever, increased ESR, valular damage, Erythema marginatum, Red-hot joints, subcutaneous nodules, Sydenham’s chorea
Pericarditis: Fibrinous vs serous vs suppurative
Fibrinous - dresslers/uremia
Serous - viral/RA/SLE
Suppurative - bacterial
Pulsus paradoxus - seen in?
Cardiac tamponade, asthma, sleep apnea, croup
Medium vessel vasculities? Risk of?
PAN, Kawasakis, Buerger’s. Infarction
Small vessel vasculities? Mech?
Type III HSR - see purpura
Microscopic polyangiits, wegners, Churg-Strauss, Henoch-Schonlein purpura
Strawberry vs cherry hemangioma?
infants, will regress vs elderly, will not regress
Vessel growth seen in pregnancy?
Pyogenic granuloma. Hemangioma that can ulcerate and bleed