Reoviridae

Question 1

What does Reoviridae mean?

Answer 1

respiratory enteric orphan

Question 2

Morphology

Answer 2

segmented (10-12)
dsRNA
70nm icosahedral
double capsid

non enveloped

Question 3

Resistance

Answer 3

Rota and orthoreo = Strong

Colti and Orbi = Weaker

Question 4

Biological properties

Answer 4

Baltimore III - viral transcriptase

Orbi, Rota: in vitro difficult to cultivate

Orthoreo: cytoplasmic inclusion bodies, rounding

Orbi, Colti – arboviruses (mosquitoes, ticks)

Question 5

Subfamilies

Answer 5

Spinareovirinae (6 genus, 35 sp.)

Sedoreovirinae (9 genus, 49 sp.)

Question 6

Sedoreovirinae

Answer 6

Orbi-, Rota- Seadornavirus genus

Question 7

Sedoreovirinae

Answer 7

(no spikes, still surface)

Orbi-, Rota- Seadornavirus genus

Question 8

Spinareovirinae

Answer 8

(spikes on the surface of the virions)

Orthoreo-, Coltivirus genus

Question 9

Orthoreovirus genus

Answer 9

(subfamiliy: spinareovirinae)

Mammalian reoviruses (1-3)

• pneumoenteritis
• euryxen: calves, lambs, foals, dogs, humans, etc.

•Avian reoviruses

• several strains
• tenosynovitis (the inflammation of the fluid-filled sheath)

Question 10

Coltivirus genus

Answer 10

(subfamiliy: spinareovirinae)

Colorado tick fever
Colorado tick fever – human fever, rash

Question 11

Orbivirus genus

Answer 11

(Subfamiliy: sedoreovirinae)
(orbis – circle)

African horse sickness:

• oedema
• haemorrhage
• pneumonia

Bluetongue:

• abortion
• cyanosis
• oedema (sheep, cattle)

Ibaraki disease – cattle, abortion, Asia
Epizootic hemorrhagic disease – deer, North America Equine encephalosis – South Africa

Question 12

Rotavirus genus

Answer 12

(Subfamiliy: sedoreovirnae)
(rota – wheel)
(omgangssyken) One of the most usual reason for children death in developing countries.

A, B, C, D, and E species (~serotypes)

Neonatal enteritis (+ E. coli) – calves, piglets, children

Question 13

Seadornavirus genus

Answer 13

(Subfamiliy: sedoreovirnae)
(South eastern Asia dodeca RNA virus)

Banna virus, Kadipiro virus, Liao Ning virus

human – influenza-like illness, encephalitis
zoononotic?

Question 14

Antigenetic properties

Answer 14

good antigens – cross reactions +/-