Poxviridae

Question 1

Morphology

Answer 1

linear dsDNA
200×400nm complex capsid with lipids
Enveloped

Question 2

Resistance

Answer 2

Usually good

Chloroform inactivates all, ether only capri-, para- and leporipoxviruses

Question 3

Biological properties

Answer 3

Baltimore I - multiplication in the cytoplasm.

embryonated eggs – CAM inoculation
mainly stenoxen
•ecombinations within genera
Orthopox, Parapox – zoonoses
infection: air borne, contact, arbo
papule (cell proliferation) → pustule → scab → scar

Question 4

Antigenetic properties

Answer 4

strong antigens (except Parapox) – long immunity

cross neutralizations within genera
- variola – vaccinia

Question 5

Subfamilies:

Answer 5

Chordopoxvirinae
Entomopoxvirinae (insects pox virus A, B, C)

Question 6

Genus

Answer 6

Chordopoxvirinae:

• Orthopox-,
• Parapox-,
• Avipox-,
• Capripox-,
• Leporipox-,
• Suipox-,
• Cervidpox-,
• Yatapox-,
• Molluscipoxvirus genus

Question 7

Orthopoxcvirus

Answer 7

(ortho – real)

Cowpox (cattle teat, skin)
rodents → cat → human

Variola (smallpox: human - skin, pneumonia, generalized)

Vaccinia (mutant cowpox – vaccine against Variola)

Monkeypox (monkey, rodent, human)

Question 8

Parapoxvirus

Answer 8

(para – like)

Pseudocowpox

• cow: teat scabs
• humans: milker’s nodule

Bovine papular stomatitis
- calf: oral scabs

Contagious ecthyma, orf

• lamb: mouth, lips - scabs
• humans: skin, lips, eyes

Question 9

Avipoxvirus

Answer 9

Fowlpox
Canarypox 
Pigeonpox 
Psittacinepox 
Turkeypox

They all gives: skin-, mucosal scabs, pneumonia, generalized forms

Question 10

Capripoxvirus

Answer 10

(capra – goat)

Sheep pox
- skin – wool loss, pneumonia, generalized

Goat pox

Lumpy skin disease
- cattle, wild ruminants

Question 11

Leopripoxvirus

Answer 11

(lepus – rabbit)

Myxomatosis

• rabbit (Oryctolagus)– myxomas, pneumonia
• transmission: mosquitoes

Hare-fibroma virus
- hare (Lepus) - tumors

Question 12

Suipoxvirus

Answer 12

(sus – swine)

Swinepox

• skin papulas
• transmission: lice

Question 13

Yatapoxvirus

Answer 13

Yabapox: monkey tumors

Tanapox: human skin lesions

Question 14

Molluscipoxvirus

Answer 14

Molluscum contagiosum virus: human skin lesions