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Virology > Nidovirales: Coronaviridae > Flashcards

Nidovirales: Coronaviridae Flashcards

1
Q

What does nidovirales mean?

A

nidus - nest

Nested set of subgenomic mRNA synthesis for the structural proteins

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2
Q

Morphology

A
  • +ssRNA genome
  • ~80nm helical capsid
  • enveloped, ~100 nm
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3
Q

Resistance

A

good pH resistance, heat labile

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4
Q

Biological properties

A
  • Baltimore IV., subgenomic mRNA synthesis
  • host specific – in vitro too
  • CPE: not characteristic (rounding, lysis)
  • HA: varies (HEV)
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5
Q

Antigenic properties

A
  • relatively good antigens

* cross-reactions within genera – „serogroups” (IF, ELISA)

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6
Q

Diagnosis

A
  • isolation (difficult) + IF
  • clinical signs, IF, IEM
  • indirect: ELISA, IF (cross-reactions), VN, (HAI)
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7
Q

Subfamilies

A

Coronavirinae

Torovirinae

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8
Q

Coronavirinae

A

Alphacoronavirus genus
Betacoronavirus genus
Gammacoronavirus genus
Deltacoronavirus genus

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9
Q

Torovirinae

A

Torovirus genus

Bafinivirus genus

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10
Q

Alphacoronavirus genus (Coronavirinae)

A

Porcine transmissible gastroenteritis virus (TGE)
•piglets – severe enteritis, diarrhoea, respiratory form

Porcine epidemic diarrhea virus (ED)

Feline infectious peritonitis virus (FIP)
•immunocomplex disease
•wet form: ascites, peritonitis
•dry form: nephritis, uremia

Canine coronavirus – enteritis, diarrhoea

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11
Q

Betacoronavirus genus (Coronavirinae)

A

Bovine coronavirus
•winter dysentery, calf diarrhoea

Porcine hemagglutinating encephalomyelitis virus (HEV)

Canine respiratory coronavirus – kennel cough syndrome

Severe acute respiratory syndrome (SARS) virus
•human pneumonia
•surfactant production ↓ - atelectasia
•natural host: palm civet cat, bat

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12
Q

Gammacoronavirus genus (Coronavirinae)

A

Avian infectious bronchitis (IB)
•chicken – respiratory symptoms
•hens – egg deformities
•nephropathogen strains – nephritis, gout

Turkey bluecomb disease
•enteritis, diarrhea
•exsiccosis, cyanosis

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13
Q

Deltacoronavirus genus (Coronavirinae)

A

Wild bird (bulbul, trush) coronaviruses

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14
Q

Torovirus genus (Torovirinae)

A

Chicken, swine, human gastroenteritis

Breda virus
•calf gastroenteritis

Berne virus
•foal gastroenteritis

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15
Q

Bafinivirus genus (Torovirinae)

A

White bream virus

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