Papillomaviridae

Question 1

Morphology

Answer 1

•circular dsDNA,
superhelical
55 nm icosahedral capsid
no envelope

Question 2

Resistance

Answer 2

strong

Question 3

Biological properties

Answer 3

Baltimore I - cellular transcriptase
virus assembly in keratinized cells
- no propagation in tissue cultures
stenoxen (restricted host range, predilection sites) oncogenic – benignant tumors
latency: episomal DNA

Question 4

transmits

Answer 4

contact, venereal transmission – cell-associated

Question 5

Antigenic properties

Answer 5

good antigens ↔ hidden for the immune system
autovaccines
no cross reactions

Question 6

Diagnosis

Answer 6

Clinical signs
IF
EM
NA hybridization

Question 7

Genus

Answer 7

Papillomavirus

Question 8

Examples of papillomaviruses

Answer 8

Equine papillomatosis – head, nose
transmission: bit, twitch

Bovine papillomatosis 1-13 – neck, back, body
horse sarcoid

Canine oral papillomatosis – oral mucosa, epulis

Human 1-63:
•Skin papillomas – verruca vulgaris
+ autosomal disorders and environmental factors → squamosus cell carcinomas
•Genital papillomas – sexually transmitted disease •Juvenile laryngeal carcinomas
•Cervical intraepithelial neoplasia
•Vulval-, penile carcinomas

Question 9

Human 1-63

Answer 9

•Skin papillomas – verruca vulgaris
+ autosomal disorders and environmental factors → squamosus cell carcinomas
•Genital papillomas – sexually transmitted disease •Juvenile laryngeal carcinomas
•Cervical intraepithelial neoplasia
•Vulval-, penile carcinomas

Question 10

Bovine papillomatosis 1-13

Answer 10

neck, back, body

horse sarcoid