Herpesviridae Flashcards
Morphology
linear dsDNA
~100 nm icosahedral capsid
enveloped – 150-200 nm
Resistance
weak
Biological properties
Baltimore I •latent infections – episoma, integration •strong CPE: - intranuclear inclusion bodies - syncytia - cell rounding, lysis •oncogenity – mainly gammaherpesviruses •generally stenoxen (a few exceptions)
Antigenic properties
weak immunogenes •cross reactions within genera - Aujeszky’s disease – IBR - EHV-1 – EHV-4 - Marek’s disease – turkey herpes (used as vaccine for marek´s disease
Subfamilies
Alphaherpesvirinae
Betaherpesvirinae
Gammaherpesvirinae
Differences in
•replication time (< 24 h or > 24 h)
•latency site (ganglia, glands, macrophages, lymphocytes) •cytopathic effects (inclusion bodies, cytomegaly, fusion)
Betaherpesvirinae
Cytomegalovirus
Muromegalovirus
Proboscivirus
Roseolovirus
Alphaherpesvirinae
Simplexvirus
Varicellovirus
Mardivirus
Iltovirus
Gammaherpesvirinae
Lymphocryptovirus
Rhadinoviurs
Macavirus
Percavirus
Diagnosis
isolation – cocultivation!
NA-hybridization,
PCR
VN for identification
Simplexvirus genus (Alphaherpesvirinae)
(Alphaherpesvirinae)
Bovine herpesmamillitis (BoHV-2)
Simian herpes (B-virus)
Human herpes simplex (HHV 1-2)
•labial and genital herpes – keratitis, encephalitis!
Varicellovirus genus (Alphaherpesvirinae)
Equine abortion/rhinopneumonitis (EHV-1, EHV-4, EHV-6)
Aujeszky’s disease – Pseudorabies (SuHV)
•swine: abortion, respiratory and CNS signs
•other species: lethal CNS disease, similar to rabies
Infectious bovine rhinotracheitis (IBR, BoHV-1, BoHV-5) •rhinotracheitis, abortion
•Infectious pustular vulvovaginitis (IPV), balanopostitis (IBP)
Canine herpesvirus (CHV-1) •nasal mucosa – puppy generalized
Human Varicella - Zoster (HHV-3)
•Chickenpox - Shingles
Mardivirus genus (Alphaherpesvirinae)
Marek’s disease virus (GaHV 2-3) •CNS signs, paralysis •lymphatic tumours
Turkey herpesvirus (MeHV-1)
Iltovirus genus (Alphaherpesvirinae)
Infectious laryngotracheitis (GaHV-1)
Cytomegalovirus genus (Betaherpesvirinae)
Human cytomegalovirus
- may cause mononucleosis like conditions.
Monkey cytomegaloviruses
Muromegalovirus (Betaherpesvirinae)
Mouse, rat cytomegaloviruses
Roseolovirus genus (Betaherpesvirinae)
Human: Roseola infectiosa (HHV 6, 7)
Lymphocryptovirus (Gammaherpesvirinae)
Epstein-Barr virus (HHV-4)
•Mononucleosis infectiosa - may damage liver and spleen in severe cases. Most people have antibodies due to early contact with the virus. Life long antibodies.
•Burkitt’s lymphoma
•Nasopharyngeal carcinoma
Baboon, monkey, ape herpesviruses
Macavirus (Gammaherpesvirinae)
Malignant catarrhal fever of cattle (AlHV-1, OvHV-2) •wildebeest, sheep – asymptomatic carrier
Pecavirus genus
Equid herpesvirus 2 – foal pneumonia + Rh. equi
Equid herpesvirus 5 – pulmonary fibrosis
Rhadinovirus genus:
Rhadinovirus genus
Bovine herpesvirus 4 (Movar) – pneumonia
Kaposi’s sarcoma-associated herpesvirus (HHV-8)
•human, in immunosuppressant patients
Fish herpesviruses (Alloherpesviridae)
Koi herpes – carp
Sturgeon, salmon herpesviruses
