Flavivirdae

Question 1

Morphology

Answer 1

• linear +ssRNA genome
• ~40nm icosahedral capsid
• enveloped – 50 nm

Question 2

Resistance

Answer 2

weak

Question 3

Biological properties

Answer 3

Baltimore IV. – single polyprotein precursor

CPE: not typical or no, Flavivirus: HA

Flavivirus:
•arboviruses – mosquito or tick
•zoonoses! – fever, hemorrhage, rash, encephalitis, hepatitis

Question 4

Antigenic properties

Answer 4

• good antigens

* cross reactions within genera

Question 5

Diagnosis

Answer 5

clinical signs
histopathology
IF
PCR 
serology: ELISA, IF, PRNT

Question 6

What does Flavivirdae mean?

Answer 6

(flavus - yellow)

Question 7

Genus

Answer 7

Flavivirus genus
Pestivirus genus
Hepacivirus genus
Pegivirus genus

Question 8

Flavivirus genus

Answer 8

Tick borne encephalitis viruses (human, goat – Europe, Asia)

Louping ill (sheep meningoencephalitis – Europe)

West Nile virus (human, horse, bird – worldwide)

Yellow fever (human – tropics)

Dengue fever (1-4) – (human – Asia, Africa)

Question 9

Pestivirus genus

Answer 9

Classical swine fever – Hog cholera
•swine – haemorrhage, fever – high morbidity and mortality

Bovine viral diarrhoea (BVD)
•calf diarrhoea, immunosuppression, tolerated infections •Mucosal disease (MD) – mucosal erosions, fatal •foetopathy, cerebellar hypoplasia

Border disease
•sheep fetopathy – „hairy shaker” lamb

Question 10

Hepacivirus genus (hepar, C)

Answer 10

Hepatitis C virus
•human serumhepatitis,
•chronic infection, cirrhosis

„Non-primate hepaciviruses”
•Canine hepacivirus
•Equine hepacivirus

Question 11

Pegivirus genus (persisting, G)

Answer 11

Hepatitis G – human

Horse, bat, chimpanzee, rodent pegiviruses