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Virology > Polyomaviridae > Flashcards

Polyomaviridae Flashcards

1
Q

Morphology

A

circular dsDNA
superhelical
icsohederal capsid
non envelope

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2
Q

Resistance

A

strong

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3
Q

Biological properties

A

Baltimore I - cellular transcriptase
oncogenic - SV40 model virus
Latency: integration into the genome - provirus
Airborn
in cell cultures - micro tumors
hemagglutination
persistent infection int the kidney - viruria

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4
Q

Diagnosis

A

IF
EM
NA-hybdridization
PCR

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5
Q

Genus

A

Polyomavirus

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6
Q

Examples of viruses

A 
SV40 
Bovine polyomavirus
Goose polyomavirus
Human:
- BK virus
- JC virus
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7
Q

JC virus

A

50-90% seropositivity, generally no clinical symptoms
rare fatal demyelization
•in immunosuppressed patients (AIDS 4%)

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8
Q

BK virus

A

80-100% seropositivity, no clinical symptoms

•nephropathy in kidney transplant recipients

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Virology (29 decks)

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