Arenaviridae Flashcards
1
Q
Morphology
A
(arena – sand)
segmented (2)
-ssRNA (ambisense) genome
no capsid!, pleomorphic
enveloped, ~120 nm
ribosomes inside the virion – no function
2
Q
Resistance
A
weak
3
Q
Biological properties
A
- Baltimore V. – viral transcriptase
- zoonoses! – encephalitis, hemorrhagic fevers
- reservoir hosts: rodents
4
Q
Antigenic properties
A
cross-reactions within the genus
5
Q
Diagnosis
A
- isolation, IF, PCR
* serology: VN, IIF
6
Q
Genus
A
Mammarenavirus genus
Reptarenavirus genus
7
Q
Mammarenavirus genus
A
New World arenaviruses
•Tacaribe-, Junin-, Machupo virus (South America)
• hemorrhage, encephalitis
Old World arenaviruses: •Lymphocytic choriomeningitis virus (LCM) - human meningitis – paresis, paralysis - pet hamsters, mice → children - Europe, USA
8
Q
Reptarenavirus genus
A
Snake arenaviruses – Inclusion body disease
