Renal - Questions Flashcards

1
Q

How can we make a solution more concentrated?

A

Take out water or add more solute

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2
Q

How can we make a solution less concentrated?

Dilute

A

Add water or take out solute

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3
Q

Where is the major site of regulated Na+ reabsorption?

A

Distal Tubule and Collecting Duct

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4
Q

Angiotensin II stimulates the secretion of what steroid hormone?

A

Aldosterone

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5
Q

What structure detectes changes in the delivery of Na+ to the TAL/DCT?

A

Macula Densa

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6
Q

This factor is the rate-limiting step in the production of angiotensin II.

A

Renin

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7
Q

The sympatheic nervous system stimulates renin secretion from the _ cells.

A

granular cells

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8
Q

Where are granular cells located?

A

Afferent Arterioles

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9
Q

In what part of the nephron is the JGA located?

A

Where the TALL meets the DT

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10
Q

Where is the K+ reabsorbed in the nephron?

A

Proximal Tubule
Thick AL

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11
Q

Where is K+ secereted in the nephron?

A

Late Distal Tubule
Collecting Duct

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12
Q

Which of the following will increase K+ seretion?
Hyperaldosteronism
Increased delivery of Na+ to the distal tubule

A

Hyperaldosteronism
Increased delivery of Na+ to the distal tubule

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13
Q

What is the proper sequence for general flow of the renal system?

A

Kidney
Renal Pelvis
Ureter
Bladder
Urethra

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14
Q

What is the proper sequence for blood flow of the renal system?

A

Renal Artery
Afferent Arteriole
Glomerulus
Efferent Arteriole
Peritubular Capillaries
Renal Vein

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15
Q

What is the proper sequence for filtrate flow of the renal system?

A

Glomerulus
Bowman’s Capsule
Proximal Tubule
Loop of Henle
Distal Tubule
Collecting Duct

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16
Q

Which of the following would cause the greatest decrease in GFR in a person with otherwise normal kidneys?
A. Decrease in renal pressure from 100 to 80 mmHg in a normal kidney
B. 50% increase in glomerular capillary filtration coefficient
C. 5 mmHg increase in glomerular capillary blood pressure
D. 50% decrease in afferent arteriolar resistance
E. 50% decrease in efferent arteriolar resistance
F. 5 mmHg decrease in Bowman’s capsule pressure

A

50% decrease in efferent arteriolar resistance

17
Q

Would GFR increase or decrease if there is…

A rise in Bowman’s Capsule pressure resulting from ureteral obstruction by a kidney stone

18
Q

Would GFR increase or decrease if there is…

A fall in plasma protein resulting from loss of these proteinsn from a large burned surface

19
Q

Would GFR increase or decrease if there is…

A dramatic fall in arterial blood pressure following severe hemorhage (<80 mmHg)

20
Q

Would GFR increase or decrease if there is…

Afferent Arteriolar vasoconstriction

21
Q

Would GFR increase or decrease if there is…

Tubuloglomerular feedback response to a decrease in tubular flow rate

22
Q

Would GFR increase or decrease if there is…

Myogenic response of an afferent arteriole stretched as a result of an increased driving BP

23
Q

Would GFR increase or decrease if there is…

Sympathetic activity to the afferent arterioles

24
Q

Would GFR increase or decrease if there is…

Contraction of the mesangial cells

25
# Would GFR increase or decrease if there is… Contraction of the podocytes
Decrease
26
Which of the following individuals would have the lowest percentage of body H20? A. A chubby baby B. A well-proportioned female college student C. A well-proportioned male college student D. An obese, elderly woman E. A lean, elderly man
D. An obese, elderly woman
27
What governs water movement vs. capillary wall?
Hydrostatic pressure (BP) Oncotic Pressure (Plasma proteins)
28
What governs water movement vs. plasma membrane?
Osmotic effects alone
29
How does hyperglycemia cause excessive urine production?
Filtered load is greater than the capacity of tubules to reabsorb it Transporters become saturated, glucose ends up in the urine
30
How do we get rid of urea?
It gets secreted back into the tubuel, by the end of descending limb of LoH, urea in the blood > tubule, so urea diffuses from vasa recta into the tubule
31
Long-term administration of furosemide would do what? A. Inhibit the Na+-Cl- cotransporters in the renal DT B. Inhibit the Na+-K+-Cl-cotransporter in the renqal tubules C. Tend to reduce renal concentrating ability D. Tend to cause hyperkalemia E. A and C F. B and C G. B, C, D
F. B and C B. Inhibit the Na+-K+-Cl-cotransporter in the renqal tubules C. Tend to reduce renal concentrating ability
32
What is the osmolarity in Bowman's capsule?
Isotonic
33
What is the osmolarity at the end of the proximal tubule?
Isotonic
34
What is the osmolarity at the tip of the LoH in the juxtamedullary nephron (bottom of the U)?
Hypertonic
35
What is the osmolarity at the end of LoH in the juxtamedullary nephron (before DT)?
Hypotonic
36
What is the osmolarity at the end of CD?
Varies ranging from hypo to hyper Low - excess water Higher - dehydration