Renal Lec 6 Flashcards
ADH/ vasopressin (type of hormone)
-peptide hormone (fast-acting)
osmoreceptors in …sense
hypothalamus sense increases in plasma osmolarity
ADH/vasopressin is produced by
cells of the SON of the hypothalamus
SON is in the
hypothalamus
SON stands for
supraoptic nucleus
vasopressin is stored in the
posterior pituitary gland
ADH secreted from
posterior pituitary gland
site of ADH action
collecting duct cells in kidney
mechanism of vasopressin action
alters water permeability of the luminal membrane of collecting duct cells
aquaporins (def.)
water channels found in renal tubule cells and other cells
number of aquaporins types in body
more than 10
type of aquaporins in proximal convoluted tubule
AQP1
type of aquaporins in collecting ducts
AQP2, AQP3, AQP4
ADH affects … insertion on… via
AQP2 insertion on the luminal side via regulation of AQP2 gene transcription
AQP on basolateral membrane
are not regulated by ADH (AQP3/4)
vasopressin receptors are on the (side of membrane)
basolateral membrane of tubule
vasopressin action mechanism (after attaching to receptors)
-vasopressin receptor activates adenylate cyclase which converts ATP to cAMP which activates PKA and causes a cycle of protein phosphorylation which control insertion of AQP2 in luminal membrane
in absence of ADH
- collecting ducts cells are almost impermeable to water
- extreme loss of large fluid volume (water diuresis)
ADH increased (pee less) by
shock, pain, warm, hot weather and water deprivation
ADH decreased (pee more) by
cold, humid environment, alcohol
diabetes insipidus
pathological condition: water diuresis, produce a large amount of dilute urine
central diabetes insipidus
failure to release ADH from posterior pituitary
nephrogenic diabetes insipidus
impaired renal tubule (especially in collecting ducts)
water diuresis (+pathological condition)
- only excess water is excreted without excess solute in urine
- diabetes insipidus
osmotic diuresis (+pathological condition)
- excess solute in urine is always associated with high levels of water excretion
- uncontrolled diabetes mellitus
relationship between body fluid volume & [Na+] regulation
-water reabsorption is dependent on Na+ reabsorption
plasma osmolarity mainly determined by
measuring the plasma Na+ concentration
changes in total body [Na+] cause changes in
blood volume and blood pressure `
low [Na+] in plasma- short term regulation
baroreceptors regulate GFR