RBC Disorders Flashcards
Rule of 3
HGB x 3 = HCT +/- 3
MCV
RBC size
HGB ranges
women- 12
men- 13.5
Hypochromic / Hyperchromic
low / high MCHC
MCHC
mean cell HGB concentration
Reticulocytes
immature circulating RBCs
Normocytic
MCV 80 - 100
Microcytic
MCV <80
iron deficiency
thalassemia
Macrocytic
MCV >100
B12 and folate deficiency
Causes of Anemia
blood loss
impaired RBC production
accelerated RBC destruction
Iron Deficiency Anemia
most common
low ferritin levels
chronic blood loss somewhere
Most common cause of microcytic anemia
Iron deficiency
Increased Reticulocytes indicates….
hemolysis or blood loss
Intrinsic Factor
needed to absorb B12
if missing will have B12 deficiency- macrocytic anemia
Time to depletion in folate deficiency
3 months
Time to depletion in B12 deficiency
3 years
G6PD Deficiency
X linked
lysis triggered by consumption of fava beans (favism)
Drugs to avoid in G6PD Deficiency
NSAIDS
antimalarials
sulfa drugs
B-Thalassemia
decreased production of HGB B-chain
a-Thalassemia
decreased production of HGB a-chain
Places where Thalassemia is most prevalent
Mediterranean- Italy and Greece
Middle East
SE Asia
S China
Thalassemia causes what type of anemia
microcytic, hypochromic anemia
