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Pathology > Autoimmune and Musculoskeletal Disorders > Flashcards

Autoimmune and Musculoskeletal Disorders Flashcards

1
Q

Lupus Erythematosis

A

can affect any organ system
triad of fever, joint pain, malar rash (butterfly pattern)
mainly in women but severe in men

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2
Q

Etiology of Lupus

A

unknown

has antinuclear Abs (ANAs) and immune complexes that cause tissue damage

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3
Q

Systemic Lupus

A

70%

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4
Q

Discoid Lupus

A

10%
only affects skin
chronic eruptions and scarring

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5
Q

Drug Induced Lupus

A

10%

symptoms stop after stop taking drug

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6
Q

Causes of Death in Lupus

A

cardiovascular disease
renal failure
infections

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7
Q

ANA Test

A

sensitive to lupus but not specific

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8
Q

Anti-dsDNA Test

A

specific to lupus, bad prognosis

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9
Q

Anti-Sm

A

specific to lupus, not prognostic

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10
Q

Lupus can cause a false _________ test

A

RPR/ VDRL
FTA/ ABS
syphillis screeners

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11
Q

Lupus Ocular Findings

A 
dry eye
episcleritis
keratitis
photosensitivity
uveitis
CRAO
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12
Q

Drugs that can cause lupus

A 
Quietly Induce Harmful Pathology
Quinidine (Cardiac)
Isoniazid (TB)
Hydralazine (cardiac)
Procainamide (cardiac)
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13
Q

What is unique about drug induced lupus?

A

transient ANA, so no anti- Sm

wont confirm on tests

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14
Q

Vasculitis

A

inflammed vessel wall that can occlude

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15
Q

Giant Cell Arteritis

A

affects large and medium arteries- aorta and ophthalmic a

blindness

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16
Q

Polyarteritis nodosum

A

lesions of small or medium aa

cotton wool spots on back of eye

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17
Q

Scleroderma

A

systemic fibrosis
tight/ shiny scarred skin
pulmonary issues can cause death

18
Q

Scleroderma patients will test….

A

ANA +

19
Q

Diffuse Scleroderma

A

widespread skin involvement, rapid progression to viscera

20% die in 10 years

20
Q

Limited Scleroderma

A

skin, fingers, face

CREST Syndrome

21
Q

CREST Syndrome

A 
Calcinosis
Raynaud phenomenon
Esophageal Dysmotility
Sclerodactyly
Telangiectasia
22
Q

Calcinosis

A

formation of calcium deposits on soft tissue

23
Q

Raynaud Phenomenon

A

vasospasm in digits
white - blue - red
overreactive to cold

24
Q

Sclerodactyly

A

thickening and tightening of skin on fingers and toes

25
Q

Telangiectasia

A

small, dilated vessels near skin or mucus membrane surface

26
Q

Diffuse/ Bad Scleroderma Test

A

Anti-Scl-70 +

27
Q

Limited/ Benign Scleroderma Test

A

Anti- centromere AB

28
Q

Ocular implications of scleroderma

A

lacrimal glands

29
Q

Sjogren Syndrome

A

autoimmune disease causing destruction of exocrine glands

dry mouth, dry eyes, arthritis

30
Q

Rheumatoid Arthritis

A

inflammatory disease of joints of hands, feet, wrists

affects PIPs

31
Q

Hypersensitivity for RA

A

4- TNF and IL-2

3- osteoclasts destroy bone and PMN destroy hyaluronic acid

32
Q

Rheumatoid Factor (RF)

A

diagnose RA- in joints

Ab (IgM) specific to Fc

33
Q

RA Ocular Manifestations

A 
Keratoconjunctivitis sicca (15-25%)
Scleromalacia perforans (15%)
34
Q

Juvenile Idiopathic Arthritis

A

ANA +; RNF - in 50%

most common cause of uveitis in children (80%)

35
Q

Seronegative Spondyloarthropathies

A

arthritis w/o RA
associated with HLA-B27
causes back pain and uveitis

36
Q

Psoriatic Arthritis

A

skin psoriasis and nail bed pitting
red plaque-like lesions on scalp, elbows, knees
uveitis

37
Q

Ankylosing Spondylitis

A

bamboo spine

uveitis

38
Q

Inflammatory Bowel Disease

A

20% have if have spondyloarthritis

39
Q

Reactive Arthritis

A

conjunctivitis/ uveitis, urethritis, arthritis

postvenereal and postdysenteric

40
Q

Sarcoidosis

A

uveitis and hypercalcemia
mainly in african americans
granuloma skin lesions, pulmonary infiltrates

Pathology (22 decks)

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