RAT 15 Flashcards
what are the three barriers that separate the blood in the glomerulus from the capsular space?
- fenestrated glomerular capillary endothelial cells
- basal lamina
- podocytes (visceral layer of the glomerular capsule)
what are the three types of capillaries?
- fenestrated
- continuous
- sinusoid
what type of capillary is the glomerulus?
fenestrated
what can pass through a fenestrated capillary?
- blood
- fluid
- waste
what cannot pass through a fenestrated capillary?
plasma proteins
what is the glomerular filtration rate (GFR)?
the rate at which filtrate is produced in the glomeruli of the kidneys
how much filtrate is produced in one day?
180 liters of filtrate
what is hydrostatic pressure?
the force of a fluid on the wall of its container
what is colloid pressure?
the pressure created by proteins (primarily albumin) in the plasma
what is net filtration pressure?
determines the direction of water between the capillaries and the interstitial fluid
what is name and abbreviation for the blood hydrostatic pressure (blood pressure) in the glomerulus? which direction is this force?
- glomerular hydrostatic pressure
- GHP
- through the filtration membrane
why is GHP higher than a typical systemic capillary?
because blood leaving such a capillary bed enter a low-resistance venule, where as blood leaving the glomerulus enters a high-resistance efferent arteriole
what is the term and abbreviation for the colloid osmotic pressure in the glomerulus? which direction is this force?
- glomerular colloid osmotic pressure
- GCOP
- opposes filtration, drawing water into the capillaries by osmosis
what is the term and abbreviation for the hydrostatic pressure in the capsular space? which direction is this force?
- capsular hydrostatic pressure
- CHP
- opposes filtration, pushes water into the glomerular capillaries
what is the name for the force that combines the three forces (GHP, GCOP, CHP)?
net filtration pressure (NFP)
which filter more fluid; systemic capillaries or glomeruli?
glomeruli
a high pressure gradient in the glomerulus will lead to _______ filtration
more
a low pressure gradient in the glomerulus will lead to __________ filtration
less
what is a way to easily adjust the pressure gradient in the glomerulus?
change diameter of afferent and efferent arterioles
in the analogy what is the afferent arteriole? the glomerulus? the efferent arteriole?
- faucet
- basin
- drainpipe
how does vasoconstriction of the afferent arteriole impact filtration?
allows less blood flood into the glomerulus, decreases GHP and GFR
how does vasoconstriction of the efferent arteriole impact filtration?
causes blood to back up within the glomerulus, increases GHP and GFR
how does vasodilation of the afferent arteriole impact filtration?
“turns up the faucet”
- increases GHP and GFR
how does vasodilation of the efferent arteriole impact filtration?
allows increased flow out of the glomerulus, decreases GHP and GFR
does the GFR rate change every time the systemic blood pressure changes? why or why not?
no because of autoregulation
where is ANP produced?
atria
what is the stimulus for the release of ANP?
volume of blood in the atria increases
what impact does ANP have on the GFR? how does that impact blood pressure?
- increases GFR
- lower BP
by which mechanism does ANP change the GFR?
dilating the afferent arterioles and constricting the efferent arterioles
what is the primary function of the RAAS?
maintaining systemic blood pressure
renin is an enzyme. what reaction does it catalyze? where is it produced?
- conversion of angiotensinogen to angiotensin-I
- JG cells
where is angiotensinogen produced?
liver
what reaction does angiotensin converting enzyme (ACE) catalyze? where is it produced?
- angiotensin-I to angiotensin-II
- lungs
what are the effects of angiotensin-II (A-II)?
- promotes vasoconstriction of efferent arterioles
- promotes vasoconstriction of systemic blood vessels
- promotes reabsorption of sodium and calcium ions from the proximal tubule, and water follows
what is renal failure?
condition where the kidneys are unable to perform their vital functions
what is uremia?
severe renal failure where FR is less than 50% of normal
what three branches of the abdominal artery supply blood to the abdominal digestive organs?
- celiac trunk
- superior mesenteric artery
- inferior mesenteric artery
what vessel drains blood from the digestive organs and where is the blood delivered?
- hepatic portal vein
- inferior vena cava
why is motility of the digestive system so important?
we do not want things to remain stagnant within the gut
which branch of the ANS tends to increase motility?
parasympathetic
which branch of the ANS tends to decrease motility?
sympathetic
describe the enteric nervous system (ENS)
a self-contained branch of the autonomic NS and regulates secretion and motility of the digestive organs
what is a lumen?
the space enclosed by a hallow organ
list the four layers found in most regions of the alimentary canal
- mucosa
- submucosa
- muscularis externa
- serosa or adventitia
what are the three components of the mucosa?
- muscularis mucosae
- lamina propria
- epithelium
what type of epithelium is found from the stomach to the end of the large intestine?
simple columnar epithelium
what is a plexus?
a cluster of nerves
where is the submucosal plexus located?
submucosa
where is the myenteric plexus located?
muscularis externa