RAT 10 Flashcards
what is phagocytosis?
the process by which cells ingest particles and other cells
what are the four phagocytic cells that provide innate immunity?
- macrophages
- neutrophils
- eosinophils
- dendritic cells
macrophages form from which cell?
monocytes
what happens to pathogens after they are ingested by macrophages?
macrophage breaks it down by mixing it with enzymes stored in lysosomes, then excreted
what is the role of NK cells?
- recognize cancerous cells and cells infected with certain viruses even though they cant recognize antigens
- activates macrophages and enhances phagocytosis
what is the complement system?
a group of proteins that function in innate immunity
what are the five ways that activated complement proteins provide protection against pathogens?
- cell lysis
- enhanced inflammation
- neutralized viruses
- enhanced phagocytosis
- clearance of immune complexes
what is a cytokine?
proteins produced by several types of immune cells that enhance the immune response in some way
name the three types of cytokines.
- tumor necrosis factor (TNF)
- interferons (IFN)
- interleukins (IL)
what is the function of tumor necrosis factor (TNF)?
can induce death of tumor cells
what is the function of interferons (IFN)?
“interfere” in the ability of the pathogen to infect other cells
what is the function of interleukins (IL)?
stimulates production of neutrophils by the bone marrow, stimulates NK cells, activating T cells
what is inflammation?
the immune system’s response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation
what are the two stages of the inflammatory response?
- damaged cells release inflammatory mediators that cause local changed in the damaged tissue
- phagocytes arrive at the area and clean up the damaged tissue
what are the four cardinal signs of inflammation?
- vasodilation of arterioles
- increased capillary permeability
- occurrence of pain
- recruitment of other cells
explain the role of phagocytes in the inflammatory response
destroy pathogenic material
what is a fever?
body temperature above the normal range (>97-99)
what chemicals initiate a fever?
pyrogens
where is the body’s thermostat located?
hypothalamus
what is the benefit of fever?
phagocytes function more efficiently at a slightly higher temperature, which helps to increase the recovery rate
list functions of the nose and nasal cavity
- warm and humidify the inhaled air
- filter out debris from inhaled air and secrete antibacterial substances
- house olfactory receptors
- enhance the resonance of the voice
the nose if formed by paired __________ bones and ________________ cartilage
- nasal
- lateral and alar
what is the anatomical term for the nostrils?
anterior nares
what is the name for the posterior openings of the nasal cavity?
posterior nares
what is the name of the most anterior part of the nasal cavity?
vestibule
name the three bony projections in the nasal cavity and the bone associated with each of them.
- superior nasal conchae (ethmoid bone)
- middle nasal conchae (ethmoid bone)
- inferior nasal conchae (independent bones)
name the three narrow passages through the nasal cavity
- superior nasal meatuses
- middle nasal meatuses
- inferior nasal meatuses
what are the hallow cavities that are not connected to the nasal cavity via small passage ways?
paranasal sinuses
in which bones are paranasal sinuses located?
- frontal
- ethmoid
- sphenoid
- maxillary bones
what is the function of the paranasal sinuses?
warm, humidify, filter the air, lighten the skill, enhance voice resonance
what tissue lines the vestibule? how is this tissue related to its function?
- stratified squamous epithelium
- enables it to be more resistant to mechanical stressors
what tissue lines the olfactory region of the nasal cavity? what is its function?
- olfactory mucosa
- houses olfactory receptors
describe the tissue that is known as respiratory epithelium or respiratory mucosa
- composed of pseudostratified ciliated columnar epithelium
- function: air filtration
what tissue lines the remainder of the nasal cavity? what is the name for this tissue? describe how this is an example of form follow function.
- pseudostratified ciliated columnar epithelium
- respiratory mucosa
- foreign cells get trapped in the mucous made by the goblet cells and the cilia beat in unison to propel to debris and mucous to the posterior nasal cavity
what interesting phenomenon occurs every 30 minutes in your nasal cavity?
the side filled with blood switches and air flows through the previously obstructed side
what is the most superior portion of the pharynx?
- nasopharynx
what tissue lines the nasopharynx?
pseudostratified ciliated columnar epithelium
what demarcates the boundaries of the nasopharynx?
uvala and soft palate