Quiz 6 Flashcards
Divisions of the skeleton
- Axial
2. Appendicular
Axial Skeleton Components
- Skull
- Vertebral column
- Hyoid bone (horseshoe shaped bone in neck)
- Rib cage
Appendicular Skeleton Components
- Pectoral girdle (clavicle and scapula)
- Upper limbs
- Pelvic girdle (hip bones and sacrum)
- Lower limbs
Components of the skeletal system
Bone and cartilage
Skeletal system functions
- Support for body and soft organs
- Protection for brain, spinal cord, and vital organs
- Movement- levers for muscle action
- Storage- minerals, growth factors, triglyceride storage
- Blood cell formation (hematopoiesis)
Long bone
Tubular, longer than they are wide
Short bone
Cuboid in shape
Flat bone
Flat, may be curved (ribs)
Irregular bone
Does not fit in the other categories
Sesamoid bone
Bone forms within tendons (big toe)
Two types of bones
- Compact (lamellar)
2. Spongy (cancellous)
Compact bone
- concentric tubes of bone matrix
- Haversion system
Haversion system
- Osteon organization- cylinders of bone
- Lamella- layers of bone that compose osteon
- Canaliculi- canals between lacunae
- Lacunae- small spaces in lamellae for osteocytes
- Osteocyte- bone cells
- Central canal- tube that houses blood vessels and nerves
Spongy bone
- Composed of trabeculae instead of osteons
- Trabeculae- form along lines of stress; porous bone
Structure of a long bone
- Diaphysis
- Epiphysis
- Articular cartilage
- Spongy bone
- Compact bone
- Medullary cavity
- Periosteum
- Endosteum
- Epiphyseal line/plate
- Red marrow
- Yellow marrow
Diaphysis
Shaft/central part of the long bone
Epiphysis
End part of the long bone
Articular cartilage
Found at the end of bones and form joints; hyaline cartilage
Medullary cavity
Central cavity that houses red/yellow marrow; stores fat (TAGS)
Periosteum
- Outer fibrous layer
- Inner osteogenic layer
- Osteoblasts (bone-forming cells)
- Osteoclasts (bone-destroying cells)
- Osteogenic cells (stem cells)
- Nerve fibers, nutrient blood vessels, and lymphatic vessels enter the bone via nutrient foramina
- Secured to underlying bone by Sharpey’s fibers
- NOTE - does not cover articular cartilage
Endosteum
- Delicate membrane on internal surfaces of bone; lines medullary cavity
- Also contains osteoblasts and osteoclasts
Epiphyseal line/plate
Growth plate (hyaline cartilage)
Red marrow
Produces red blood cells, platelets and most white blood cells
Yellow marrow
Produces some white blood cells
Bone development
Begins to form during 3rd month; mothers need to ingest more calcium
Endochondral ossification
- Most common form of bone formation in appendicular skeleton
- Chondrocytes die and osteoblasts and blood vessels invade
Intramembranous ossification
- Superficial flat bones in head
- Direct formation of bone within mesenchyme
- i.e. clavicle, mandible, flat bones of neurocranium
Cartilage formation
-Begins around week 5
1. Chondroblasts proliferate
2. Blood vessels regress
3. Chondroblasts differentiate into chondrocytes
-chondroblasts remain at periphery of cartilage forming
the perichondrium
4. Chondrocytes secrete matrix
Cartilage cells
- chondroblasts- differentiate into chondrocytes
- chondrocytes- mature cartilage cell
Sclerotome
- part of a somite that develops from paraxial mesoderm
- bone/cartilage of axial skeleton
- some skull
- vertebrae (half of 2 sclerotomes)
- Intervertebral discs –> annulus fibrosus
- ribs
Neural crest cells
Facial skull bones
Somatic lateral plate mesoderm
- Sternum (axial skeleton)
- Cartilage and bones (appendicular skeleton)
Appendicular skeleton formation
- Formed by endochondral ossification
- Cartilage formed week 5-8
- Ossification begins in 3rd month until 20 years old
- Girdles form with limb and migrate to axial skeleton
- Signaling gradients induce limb bone formation
Limb formation
- Limb buds appear in week 4
- Upper limbs lead lower by 1-2 days
- Digits formed by apoptosis on most distal portion (surface ectoderm) and its interaction with underlying somatic lateral plate mesoderm
- Muscle and nervous tissue migrate into the limbs
Congenital defects
- Amelia: while limb mission
- Meromelia: part of limb missing
- Syndactyly: fusion of digits
- Polydactyly: too many digits
- Cleft foot: toes don’t form; looks like a hoof
Fontanelles (fetal skull)
- Fibrous tissue present prior to suture fusing in neurocranium
- Functions:
- Allow brain growth
- Allow birthcanal passage
Fontanelle positions and number
- Anterior (Frontal)- 1
- Posterior (Occipital)- 1
- Anterolateral (sphenoidal)- 2
- Posterolateral (mastoid)- 2