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Q-Fever Flashcards

1
Q
  1. What are the other names that Q-fever goes by?
A

a. • Query Fever

b. • Coxiellosis

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2
Q
  1. What is the causative agent of Q-fever?
A

a. . Coxiella burnetti

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3
Q
  1. Is Coxiella burnetti gram positive eor gram negative?
A

a. Graham neg

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4
Q
  1. Is Coxiella burnetti a spore former?
A

a. Yes

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5
Q
  1. Can pasteurisation kill Coxiella burnetti?
A

a. Yes

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6
Q
  1. Coxiella burnetti exists in ______ antigenic phase
A

a. Two

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7
Q
  1. What are the two antigenic phases that Coxiella burnetti exists in?
A

a. •Phase 1: virulent

b. •Phase 2: less pathogenic

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8
Q
  1. What is the phase 1 of Coxiella burnetti?
A

a. Virulent

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9
Q
  1. What is phase 2 of Coxiella burnetti?
A

a. Less pathogenic

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10
Q
  1. Where does Coxiella burnetti replicate?
A

a. Monocytes or macrophages

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11
Q
  1. What was Coxiella burnetti thought to be originally and why?
A

a. Rickettsial agen

b. Transmitted by tick

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12
Q
  1. What phylum does Coxiella burnetti belong?
A

a. Proteobacteria.

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13
Q
  1. What other bacteria are part of the proteobacteria?
A

a. Legionella and salmonella

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14
Q
  1. What percentage of bacteria are proteobacteria?
A

a. 32%

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15
Q
  1. All proteobacteria are Gram Positive (t/F)
A

a. False

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16
Q
  1. Is Coxiella burnetti an environmentally stable organism?
A

a. Yes

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17
Q
  1. Why is Coxiella burnetti able to be so resistant to deissinfection agents that normally kill bacteria?
A

a. Its spore structures

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18
Q
  1. How long can Coxiella burnetti spore survive in room temperature outside of a host?
A

a. 7-10 days

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19
Q
  1. How long can Coxiella burnetti spores survive in a fresh meat stored at 4C?
A

a. A month

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20
Q
  1. How many day s can Coxiella burnetti spores survive in dust?
A

a. 120days

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21
Q
  1. How long can Coxiella burnetti spores survive in skim milk?
A

a. 40 months

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22
Q
  1. How can Coxiella burnetti spores be killed?
A

a. pasteurisation

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23
Q
  1. What is the phase that Coxiella burnetti is most commonly found?
A

a. Phase 1

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24
Q
  1. When is phase 2 of Coxiella burnetti typically discovered?
A

a. Through multiple passes of cell culture in the lab.

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25
25. Phase one is a _________ infection whereas phase two is a ________ infection.
a. Chronic | b. Acute
26
26. How does Coxiella burnetti infect macrophages?
a. Binds to an αvβ3 integrin: Triggering phagocytosis i. This is an actin dependent mechanism b. Nascent (beginning once inside the cell) Coxiella-containing vacuole (CCV) acquires early endosome markers i. RAB5 , EEA1 and microtubule-associated protein light-chain 3 (LC3 - autophagosome marker) ii. This can take place within 5 minutes of the bacterium being internalised c. Autophagosome binds to the nacent CCV i. Lowers the pH to ~5.4 d. Maturing CCV acquires RAB7 and lysosome-associated membrane glycoprotein 1 (LAMP1) i. The pH then decreases even further ~5 pH e. Lysosomal enzymes – eg cathepsin D (CTSD) start to accumulate i. pH drops again to ~4.5 ii. This happens within 2 hours of internalisation f. Conversion of bacteria from small cell variants (SCVs) to metabolically active large cell variants (LCVs) - involves the recruitment of both RHO GTPase and RAB1B i. RAB1 is recruited from the endoplasmic reticulum thought to acquisition of additional membranes to create a large vacuole
27
27. What is the estimated life cycle from invasion of macrophages to production of large replication vacuoles?
a. 20 hours
28
28. _________ – Febrile disease -Abattoir workers, Brisbane: What was the desease called at this stage and why?
a. 1935 b. Query fever c. As the cause fo the disease was unknown
29
29. The disease is named after a scientist called _____?
a. Burnet
30
30. _________ Montana, USA – pathogen isolated from ticks in the nine mile.
a. 1938
31
31. ________ the bacterium got the name coxella burnetti because of the two scientists
a. 1938
32
32. ______ a lot of cases being reported amongst military personal, both USA and British, in Mediterranean particularly Italy
a. 1940
33
33. In the 1940s those in cities became ill form Coxiella burnetti, these cities where down wind of infected farmsm, which led to what discovery
a. The disease is Airborne
34
34. Ho can Coxiella burnetti be transmitted?
a. Aerosol b. Direct contact c. Fomites d. Ingestion e. Ticks: Arthropods
35
35. What is the most common animal to spread Coxiella burnetti to humans and through what transmission route?
a. Cows, sheeps, and goats | b. Aerosols
36
36. How can aerolisation of Coxiella burnetti happen?
a. Parturient fluids i. • 109 bacteria released per/gram /placenta b. – Urine, faeces, milk c. Blood from meat plants
37
37. What is a parturient fluid?
a. Birthing fluids | b. NASSSY
38
38. What fomites can be an issue?
a. Can survive on clothes for 7-10 hours | b. Can survive on animal bedding and other items
39
39. How is Coxiella burnetti typically consumed?
a. Unpasteurised milk b. Infected meats c. Placenta when eaten by animal, including pets
40
40. What kind of infection is it when an arthropod passes the Coxiella burnetti down to the offspring?
a. Transovarial infection
41
41. What is a transtatial infection?
a. Passed between life cycle stages
42
42. ~What arthropods can spread Coxiella burnetti?
a. Flies b. Lice c. Beetle d. Ticks e. Coachroaches f. Mites
43
43. How long can infection persist in an artropd?
a. Up to nine months
44
44. How is person-Person transmitted?
a. Congenital b. – Blood transfusions c. – Bone marrow transplants d. – Intradermal inoculation e. – Possible sexual Transmission
45
45. Is person to person common?
a. NOPE
46
46. Where is Coxiella burnetti found?
a. Globally apart from new Zealand
47
47. What reseviours are there of Coxiella burnetti?
a. Domestic farm Animals: Sheep, cattle, goats, dogs, cats b. Birds c. Repltiles d. Wildlife e. Ticks
48
48. What are the three main reseviours of the Coxiella burnetti?
a. Sheep, goats, and ticks
49
49. Nova scotia have other reservoirs which are?
a. Wild life: snow shoes hares, whitel tailed deer, and moose
50
50. In Americas what is another reseviour of Coxiella burnetti?
a. Black bears
51
51. In what direction is it thought that the spill over goes between domestic and wild animals?
a. Spill over from farm  the wild bois
52
52. What are the high risk occupations?
a. Agricultural workers b. –Livestock producers c. –Veterinarians & nursing staff d. –Meat processors/abattoir e. workers f. –Laboratory workers g. –Wildlife workers
53
53. What is the prevalence in UK… of that population of infected how many are farmers 15%, an what is the explanation for the rest of the infected?
a. UK 5% population seropositive b. 15% farmers c. Unknown
54
54. ____-______ sporadic cases/year reported of Coxiella burnetti infection each year, but this is thought to be grossly underestimated as ________% of cases are asymptomatic.
a. 50-100 | b. 60%
55
55. Is infection with Coxiella burnetti in children uncommon…..
a. Yes it is
56
56. There was an outbreak in _____, with 95 cases thought to be caused by airborne transmission, from ________ who gave birth in the straw in the walls.
a. 2002 | b. mice
57
57. Outbreak in ________ with 30 people infected, living down wind from a farm
a. 2007
58
58. Outbreak, in a farm dance from contaminated from ___________ from birthing sheep
a. Haybales
59
59. Q. Fever in N, Ireland Peakined in _______ with 35 people being infected but has continued to decrease with an average of 1-2 cases per year
a. 2000
60
60. _______ to _______ was the greatest outbreak of Coxiella burnetti, in Netherlands because of ________ farms, with 4,000 cases and there were __________ animals euthanized.
a. 2007 -2010 b. Dairy goat c. 50,000 euthanized, all with twin pregnancy
61
61. In the 2007-2010 Netherlands outbreak what were the most common patients to become infected with Coxiella burnetti?
a. Male b. Smokers c. 40-60years of age
62
62. The most common (______%) clinical presentation of Coxiella burnetti in the 2007-2010 outbreak was _________
a. 62% | b. Pneumonia
63
63. What was the percentage of people working in an agricultural position or the meat processing industry in the 2007-2010 Netherlands outbreak?
a. 2% | b. 0.5%
64
64. The outbreaks of the 2007-2010 Netherlands outbreaks of Coxiella burnetti coensided with what phenomenon?
a. Coxiella burnetti induced abortions in the dairy goats
65
65. In Denmark __________ 18 million mink culled when worker introduced covid-19.
a. 2022
66
66. Disease manifestation in humans: a. incubation period b. mean incubation rate c. % asymptomatic. D. how longs acute infection. E. how lond is the chronic infection
a. 2-40 days b. 20 days c. 50-60% asymptomatic d. Acute: 6month e. Chronic: 6+ months
67
67. In regards tp humans we are a ___________ host.
a. Dead end host | b. Bad at passing the disease on
68
68. How does acute Coxiella burnetti infection manifest? What is the percentage of deaths?
a. Flu-like, self limiting b. Atypical pneumonia (30 to 50%) c. Hepatitis d. Skin rash (10%): Exanthema e. Other signs (< 1%) i. –Myocarditis (heart inflammation) meningoencephalitis (behavioural problems), pericarditis (pericardium inflammation) f. Death: 1 to 2%
69
69. Those with acute acute Coxiella burnetti infection that develop atypical pneumonia what can this develop into? And what does it appear as in an xray? What else develops?
a. Pneumonitis b. Viral pneumonia c. Pleural infusion: liquid build up
70
70. How does the chronic disease manifest? A. How long does it last. B.What percentage of people infected with Coxiella burnetti get this form? C. Who is at higher risk of this form? D. What is the most common manifestation e. Where can granulomas develop and what issues does this lead to? F. Where is can be infected? G. What is the relapse rate after antibiotic treatment?
a. 6+ months b. 1-5% c. Heart problems, pregnant women, immunocompromised, organ transplant and cancer d. Endomyocardial disease e. Liver: cirrhosis and Granulomatous hepatitis f. Bone: osteoperosis g. 50% relapse
71
71. Where do scientist believe are the target cells for Coxiella burnetti?
a. Kupffer
72
72. How long can someone with the acute form of Coxiella burnetti infection develop the chronic form?
a. Up to 20 years after
73
73. The majority of women who are pregnant are manifest the disease Coxiella burnetti how?
a. Asymptomatically b. Premmie birth c. Placentitis
74
74. Coxiella burnetti is usually ________ resolving in _____ days to ______ weeks
a. Self limiting | b. 2days to 2 weeks
75
75. Only ________ develop severe disease of Coxiella burnetti.
a. 2%
76
76. When Coxiella burnetti is not treated and the chronic form develops there is a ____% mortality rate. The patients require a ______ replacment
a. 65% | b. Valve
77
77. How is Coxiella burnetti disgnosed?
a. Serology (rise in antibody titer levels) i. – IFA, CF, ELISA, microagglutination b. • DNA detection methods i. – PCR c. • Isolation of organism i. – Risk to laboratory personnel ii. – Rarely done d. • Clinical signs/patient history aid diagnosis
78
78. How is Coxiella burnetti treated?
a. Doxycycline b. –Quinolones c. –Chronic disease – long course i. •2 to 3 years of medication d. • Pregnant women - co-trimoxazole (trimethoprim/sulfamethoxazole combination) e. • Immunity –Long lasting (possibly lifelong)
79
26. Coxiella burnetti does something unusual when it enters the macrophages for replication, that most bacteria prevent when they replicate in the macrophages… What is it?
a. Thye actively turn on the mechanisms to create Coxiella-containing vacuole (CCV)
80
80. Coxiella burnetti can change between ______(SCVs) and ________(LCV)
a. Small cell variants | b. large cell variant
81
81. What is a Small cell variants (SCVs)?
a. a. When inactive and not within the acidification of a host b. Metabolically inactive
82
82. What is the difference between a phase 1 and phase 2 organism?
a. Virulent smooth cell variants contain LPS with a complete O antigen and are referred to as phase I organisms, whereas avirulent rough cell variants lack the terminal O antigen sugars and are referred to as phase II organisms. The identification and characterization of other virulence factors has been facilitated by two recent advances: the development of axenic culture media and improvements in the tools available for genetic manipulation
83
83. What type of phagocytosis takes place with Coxiella burnetti and what ype of macrophage does it enter?
a. Actin dependent phagocytosis | b. Alveolar macrophages
84
84. What is αVβ3 integrin typically involved in?
a. The removal of apoptosis cells | b. Inflamation
85
85. Although the identity of the bacterial ligand for αVβ3 integrin has not been determined, a class of likely candidates would be membrane-associated proteins that contain the integrin-binding domain ________(RGD)
a. arginine-glycine-aspartic acid
86
86. αVβ3 integrin is poorly expressed on ______monocytes, so it is likely that C. burnetii uses other ______to invade these cells
a. resting | b. receptors
87
87. What are the symptoms most common in animals?
a. Aymptomatic b. Reproductive failure c. Sheep can be chronically infected
88
88. What is reproductive failure?
a. Abortions b. •Stillbirths c. •Retained placenta d. •Infertility e. •Weak newborns f. •Low birth weights
89
89. Reproductive failue commonly leads to P__________. Which is?
a. Placentitiis b. Leathery and thickened c. –Purulent exudate d. •Edges of cotyledons e. •Intercotyledonary areas
90
90. What is a cotyledonary placenta?
a. Instead of having a single large area of contact between maternal and fetal vascular systems, these animals have numerous smaller placentae. The terminology used to describe ruminant placentation is: Cotyledon: the fetal side of the placenta.
91
91. How does the cotyledonary placenta in an infection look like?
a. Cottage cheese
92
92. What symptoms does the aborted feautus show?
a. None that points to a C. burnetii infection
93
93. How is diagnosis complete?
a. – Identification of organism (Modified Ziehl-Neelson or Gimenez stains, IHC) i. NOT Gram Stain b. – PCR c. – Serologic tests: IFA, ELISA, CF d. – Isolation of organism: Hazardous - Biosafety level 3
94
94. What Treatment is there animals?
a. Tetracycline prior to parturition
95
95. What percentage of sheep are seropositive and cattle in endemic regions?
a. 55% sheep | b. 82% cows
96
96. What is the prevalence of C. burnetii in the environment?
a. 23.6%
97
97. What ways are there to control C. burnetii ?
a. Animal husbandry b. Tick prevention c. Destoy placenta d. Isolate ill e. Vaccine in countries where available f. Pasteurisation g. 10% bleach h. Education
98
98. How can C. burnetii be used as a bioweapon?
a. Aerosolised b. Sporeforming c. 5kg released to 5 million  125,000 ill and 150 deaths d. Stabke in the environment e. Only 1 organism required for infection f. Can be blown 20km in the wind

Zoonoses (23 decks)

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