Aileen Borrelia burgdorferi/Lyme Flashcards
What is a chemoreceptor?
Chemoreceptor arrays are supramolecular transmembrane machines of unknown structure that allow bacteria to sense their surroundings and respond by chemotaxis.
What outersurface proteins does Borrelia burgdorferi produce? were do they aid in colonisation?
OspA and OspB: The gut
What is a β-barrel outer-membrane-spanning protein?
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane.
What type of zoonoses does Borrelia burgdorferi cause?
Enxootic
What is the the name of the bacteria that results in Lyme disease?
Borrelia burgdorferi
What is a VlsE protein?
is an antigenically variable cell- surface protein that evades the antibody response by continu- ously changing its surface epitopes (Norris, 2006), and it could potentially function to shield Arp from antibodies.
What is a VlsE protein?
is an antigenically variable cell- surface protein that evades the antibody response by continu- ously changing its surface epitopes (Norris, 2006), and it could potentially function to shield Arp from antibodies.
What is the taxonomy of Lyme disease?
Family: Borreliaceae
Genus: Borrelia
Species: Borrelia burgdorferi
What serovars or clads are there with Borrelia burgdorferi?
23 clads
What is the morphology of Borrelia burgdorferi?
Morphology: Spirochette, flat wave Size: 0.3 μm wide and 5 to 20 μm in length Flagella: Axial filament and seven to eleven bundled periplasmic flagella Outermenbrane: No lipopolysaccharides in outer membrane, Chemoreceptors, outer-surface lipoproteins OspA and OspB(high density), β-barrel outer-membrane-spanning proteins such as BamA, VlsE protein DNA: Linear chromosome and plasmids peptidoglycan: attached to the inner membrane instead of the outer membrane
What Gram is Borrelia burgdorferi?
Gram-Negative
What O2 is required for Borrelia burgdorferi?
Microaerobic
What is the motility situation of Borrelia burgdorferi?
Axial filament and seven to eleven bundled perisplasmic flagella
Can Borrelia burgdorferiform spores?
cysts: Some species can encyst to when conditions are not favourable within body tissue (Miklossy et al 2008).
What did (Miklossy et al 2008) publish about?
That Borrelia burgdorferican form cycts in the body when conditions become unfavourable and survive for extended periods of time.
What is the survival rate of Borrelia burgdorferi?
Months to years in a mammillian host
What is the lethal dose or fatality of Borrelia burgdorferi?
Low Fatality Rate: 300,000 cases in USA and 65,000 in the EU each year
What is Borellia burgdorferi life cycle?
Ixodes Tick –> vertabrate –> Ixodes Tick
What is the infection route of Borellia burgdorferi?
- Tick: takes blood meal 2. Blood Stream: B. burgdorferi enters the blood 3. Epigenetics: upregulatin anf repression of different genes to compinsate for entering the human host increase in temperature, different pH, and different nutrient availability 4. adherence: adherence to the vascular cell walls within the host, BBK32 bacterial protein creates a strong bond with the host blood vessel cell wall, they have the capability to alter their antigens and avade host detection. 5: Evasion: Evades host through VlsE proteins which continually change their epitopes
What is the history of Borrelia burgdorferi?
Otzi ice man: confirmed Borrelia burgdorferi
1764: John Walker, first description of lymes disease and linking it to the tick
1894: tick DNA from Ixodes specimen in a meuseum contained Borrelia burgdorferi DNA.
1920s: started to recognised the neurological symptoms from the Lyme disease
1950: Pennicillin started to be used to treat tick bites and Lyme disease
1975: First named the disease when children in conneticut were thought to have reumitoid arthritis
1985: reportable disease
