Pulm and Critical Care V Flashcards
What is the recommended treatment for patients with SIADH who have severe hyponatremia (e.g. seizures, coma)?
Hypertonic (3%) saline
What is the recommended treatment regimen for patients with intermittent asthma?
Short-acting β2-agonist, PRN
What is the recommended treatment regimen for patients with mild persistent asthma?
daily low-dose inhaled corticosteroid and SABA PRN
What is the recommended treatment regimen for patients with moderate persistent asthma?
daily long-acting β2-agonist, daily low-dose ICS, SABA PRN
or daily medium-dose ICS with SABA PRN
What is the test of choice to diagnose pulmonary embolism in clinically stable patients with a high likelihood of PE (modified Wells > 4)?
CT angiography
in patients with low likelihood of PE (modified Wells < 4), D-dimer testing can help rule out PE due to high negative predictive value
What is the underlying cause of low glucose in complicated parapneumonic effusions?
High metabolic activity of leukocytes and/or bacteria
What is the underlying etiology for aspiration pneumonia in patients with impaired consciousness and/or advanced dementia?
impaired swallowing and cough reflex
What is the underlying etiology in a patient with severe COPD who develops altered consciousness and seizures after administration of supplemental O2?
O2-induced CO2 retention
patients have a decreased respiratory drive and loss of compensatory vasoconstriction
What is the underlying etiology of aspirin-exacerbated respiratory disease?
aspirin-induced prostaglandin/leukotriene imbalance
this is a non-IgE-mediated reaction (pseudo-allergic reaction); treatment includes avoidance of NSAIDs and/or administration of leukotriene receptor antagonists (e.g. montelukast)
What maternal pathology is associated with increased risk for neonatal respiratory distress syndrome?
Maternal diabetes
maternal diabetes results in fetal hyperinsulinism, which antagonizes cortisol and blocks maturation of sphingomyelin
What medications should be administered to patients with severe asthma exacerbation?
[…], […], […]
inhaled short-acting β2 agonists, inhaled ipratropium, systemic corticosteroids
additional bronchodilation with one-time infusion of IV magnesium sulfate may be added if no improvement appreciated after an hour
What paraneoplastic syndrome presents with euvolemic hyponatremia?
SIADH
other common findings include low serum osmolality (< 275 mOsm/kg) and high urine osmolality (> 100 mOsm/kg)
What physiologic change helps compensate for chronic respiratory acidosis and hypercapnia in patients with COPD?
Increased renal HCO3 retention
i.e. compensatory metabolic alkalosis; similar changes may occur with other pulmonary pathologies (e.g. obesity hypoventilation syndrome)
What pneumonia complication is characterized by frank pus or bacteria in the pleural space?
Empyema
What regions of the lung are most commonly involved in supine patients with aspiration pneumonia?
[…] and […]
posterior segments of upper lobe and superior segments of lower lobe
What risk factor acts synergistically with asbestos to increase risk of lung cancer?
Smoking
asbestos alone increases risk by nearly 6-fold; smokers with asbestos exposure have nearly 59-fold increased risk
What test/imaging study is the best diagnostic test for bronchiectasis?
high-resolution CT scan of the chest
characteristic findings include bronchial dilation, lack of airway tapering, and bronchial wall thickening (arrows)
What test/imaging study should be ordered first to evaluate an older patient with a 30 pack-year smoking history and recurrent episodes of pneumonia in the same anatomic location?
CT scan of chest
in patients > 50 with significant smoking history (> 30 pack-years), it is essential to evaluate for lung malignancy; CT scan has better sensitivity than CXR