Psych.pptx Flashcards
Which are names of ANTIPSYCHOTIC
a. Antipsychotics
b. Neuroleptics
c. Dopamine Antagonists”
d. Dopamine/Serotonin Antagonists
All
Which isANTIPSYCHOTIC used for ?
a. Hallucinations
b. Delusions
c. Schizophrenia
d. Paranoia
e. Bipolar Disorder
g. Nausea/Vomiting
All
First Generation Antipsychotics:
a. low potency
b. Moderate Dopamine Antagonists
c. high potency
d. Atypical
e. FGA
f. Conventional
g. SGA
h. Added Serotonin Antagonist properties
i. Primary Mechanism: STRONG Dopamine Antagonists
a. low potency
c. high potency
e. FGA
f. Conventional
i. Primary Mechanism: STRONG Dopamine Antagonists
Second Generation Antipsychotics:
a. low potency
b. Moderate Dopamine Antagonists
c. high potency
d. Atypical
e. FGA
f. Conventional
g. SGA
h. Added Serotonin Antagonist properties
i. Primary Mechanism: STRONG Dopamine Antagonis
b. Moderate Dopamine Antagonists
d. Atypical
g. SGA
h. Added Serotonin Antagonist properties
Which drugs are First Generation Antipsychotics:
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
a Chlorpromazine
c haloperidol
Which is High Potency (FGA)
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
c. haloperidol
Which is Low Potency (FGA)
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
a. Chlorpromazine
Which drugs are Second Generation Antipsychotics:
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
d. clozapine
e. risperidone
Which are Mood Stabilizer
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
b. LITHIUM
Which has a STRONG Blockade of D2 receptors
a. Chlorpromazine - FGA
b. LITHIUM- Mood Stabilizer
c. haloperidol - FGA
d. clozapine SGA
e. risperidone - SGA
a. Chlorpromazine - FGA
c. haloperidol - FGA
FGA blocks which?
a. Histamine
b. NE (alpha-1)
c. Acetylcholine (muscarinic)
d. 5HT
e. METABOLIC
a. Histamine
b. NE (alpha-1)
c. Acetylcholine (muscarinic)
d. 5HT
What is the common Adverse side effects for all FGA? H- O- M- E- L- E- S- S-
Heart Problems Orthostatic Hypotension Muscarinic Blockade Extrapyramidal Symptoms (Know all 4!) Life threatening Neuroleptic Malignant Syndrome Extremely Sedated Sexual Dysfunction Seizures/ Size Increase/Sunlight/ Skin!
Which are Dopamine Blockade?
a. Nigrostriatal- EPS
b. Mesocortical-associated with negative
c. Mesolimbic- treat positive symptoms
d. Tuberoinfundibular- Hyperprolactinemia
a. Nigrostriatal- EPS
b. Mesocortical-associated with negative
c. Mesolimbic- treat positive symptoms
d. Tuberoinfundibular- Hyperprolactinemia
Dopamine Blockade- treat positive symptoms
a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-
c. Mesolimbic-
Dopamine Blockade- treat positive symptoms
a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-
c. Mesolimbic-
Dopamine Blockade - Hyperprolactinemia
a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-
d. Tuberoinfundibular-
What are the 4 EXTRAPYRAMIDAL SYMPTOMS (EPS)
a. Pseudoparkinsons
b. Nigrostriatal-
c. Akathisia
d. Mesocortical-
e. Mesolimbic-
f. Acute dystonia
g. Tuberoinfundibular-
h. Tardive Dyskinesia
a. Pseudoparkinsons
c. Akathisia
f. Acute dystonia
h. Tardive Dyskinesia
What are the 4 EXTRAPYRAMIDAL SYMPTOMS (EPS)
a. Pseudoparkinsons
b. Nigrostriatal-
c. Akathisia
d. Mesocortical-
e. Mesolimbic-
f. Acute dystonia
g. Tuberoinfundibular-
h. Tardive Dyskinesia
a. Pseudoparkinsons
c. Akathisia
f. Acute dystonia
h. Tardive Dyskinesia
What treats the 4 EXTRAPYRAMIDAL SYMPTOMS anticholinergics a. Benztropine (Cogentin®) b. Trihexyphenidyl, c. Diphenhydramine d. Haloperidol e. DANTROLENE
a. Benztropine (Cogentin®)
b. Trihexyphenidyl,
c. Diphenhydramine
What treats NEUROLEPTIC MALIGNANT SYNDROME:
a. Benztropine (Cogentin®)
b. Trihexyphenidyl,
c. Diphenhydramine
d. Haloperidol
e. DANTROLENE
e. DANTROLENE
NEUROLEPTIC MALIGNANT SYNDROME Halperadole F E V E R
Fever Encephalopathy Vitals Unstable Elevated enzymes (CPK) Rigidity
Don’t touch the oral solution?
a. can not cause contact dermatitis!
b. can cause contact dermatitis!
b. can cause contact dermatitis!
Which inhibit D2 (moderate) and 5HT (strong)
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
Which is LESS likely to cause EPS
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
Which has Metabolic Syndrome!
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
so naturally, Cost $$$ More
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
Which can cause dysrhythmias and DEATHBOXED WARNING: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
both
Which mixed serotonin-dopamine antagonist activity that binds to 5-HT2-receptors in the CNS and in the periphery with a very high affinity; binds to dopamine-D2 receptors with less affinity
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
What is associated with Monitor for Metabolic Syndrome
a. Glucose
b. cholesterol
c. weight gain
All
Which drug deals with
- Increased mortality in elderly patients with dementia-related psychosis
- 2)Orthostatic hypotension, bradycardia, syncope
- Seizures
4) Myocarditis and cardiomyopathy: - 5) Severe neutropenia (1% patients):
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
d. clozapine
Which deal with elevated prolactin (hyperprolactinemia) General Sexual dysfunction Gynecomastia Galactorrhea Menstrual irregularities a. 1st Generation Anti-psychotics b. 2nd Generation Anti-psychotics
Both
Which drug uses REM
a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone
d. clozapine
1st Generation
a. ADDED METABOLIC SYNDROME
b. HIGH RISK FOR EPS
c. higher dopamine blockade (D2)
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms
b. HIGH RISK FOR EPS
c. higher dopamine blockade (D2)
2nd Generation
a. ADDED METABOLIC SYNDROME
b. HIGH RISK FOR EPS
c. higher dopamine blockade (D2)
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms
a. ADDED METABOLIC SYNDROME
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms
1st Generation adverse side effects H O M E L E S S Size Increase/Sunlight/Skin Extrapyramidal Symptoms Muscarinic Blockade Orthostatic Hypotension Sexual DysfunctionSeizures Extremely Sedated Life threatening Neuroleptic Malignant Syndrome Heart Problems METABOLIC SYNDROME!
Heart Problems Orthostatic Hypotension Muscarinic Blockade Extrapyramidal Symptoms Life threatening Neuroleptic Malignant Syndrome Extremely Sedated Sexual DysfunctionSeizures Size Increase/Sunlight/Skin
2nd Generation adverse side effects H O M E L E S S Size Increase/Sunlight/Skin Extrapyramidal Symptoms Muscarinic Blockade Orthostatic Hypotension Sexual DysfunctionSeizures Extremely Sedated Life threatening Neuroleptic Malignant Syndrome Heart Problems METABOLIC SYNDROME!
Heart Problems Orthostatic Hypotension Muscarinic Blockade: METABOLIC SYNDROME! Extrapyramidal Symptoms Life threatening Neuroleptic Malignant Syndrome Extremely Sedated Sexual DysfunctionSeizures Size Increase/Sunlight
Which is true about lithium
a. if high sodium, body reabsorbs sodium, and also lithium
b. if low sodium, body reabsorbs sodium, and also lithium
b. if low sodium, body reabsorbs sodium, and also lithium
Which is true about lithium
a. if high sodium, body reabsorbs sodium, and also lithium
b. if low sodium, body reabsorbs sodium, and also lithium
c. normal sodium and fluid levels aren’t essential
d. normal sodium and fluid levels are essential
e. risks- dehydration, diarrhea,
b. if low sodium, body reabsorbs sodium, and also lithium
d. normal sodium and fluid levels are essential
e. risks- dehydration, diarrhea,
Which of the following can lower sodium and increase lithium toxicity
a. Diuretics
b. OPIOIDs
c. NSAIDs
d. ACE-I ◦
e. Any drying out drug- Anticholinergics, Tricyclic Anti-depressants
a. Diuretics
c. NSAIDs
d. ACE-I ◦
e. Any drying out drug- Anticholinergics, Tricyclic Anti-depressants
What are this seizures, ataxia, blurred vision, involuntary muscle movements, renal failure, coma, EKG changes, severe hypotension, death
a. Opiod overdose
b. lithium overdose
b. lithium overdose
This can treat Gastric lavage, potentially hemodialysis
a. Opiod overdose
b. lithium overdose
b. lithium overdose
Does lithium have muttiple have lives and should be given with food
Yes or No
yes
Lithium- .? to ? mEq/L
.6
1.2
L I T H I U M
L evels (0.6-1.2 mEq/L)
Increased urination (polyuria)Insipidus
TremorsThirst
Hypothyroidism
Interactions (NSAIDS,ACE-Is,Diuretic, etc.)
Upset stomach
Muscle weakness/ Miscellaneous- EKG changes)