Coagulation Flashcards
General term for any process that stops bleeding?
homeostasis or Hemostasis
Hemostasis
Which is reinforcement of platelet plug with fibrin
ANTIPLATELETS , COAGULATION, ANTICOAGULANTS
COAGULATION
Which comes first in Hemostasis stages
Coagulation , Formation of a platelet plug
Formation of a platelet plug
Coagulation
STAGE ONE- Formation of platelet plug fill in blank!
- Damaged blood vessel
- Platelets come into contact with collagen on exposed surface of damaged vessel.
- Platelets ? to damage site (von Willebrand Factor via GP 1b)
- ? initiates platelet ?
- ? leads to platelet ?
adhesion, adhere, activation, aggregation
adhere adhesion activation activation aggregation
STAGE ONE- Formation of platelet plug fill in blank! CON
- activation leads to platelet ?
- Aggregation- ?
- results in formation of ? between ? on adjacent platelets
- ? create a plug that stops bleeding ?Stable or Unstable? plug
complex process, glycoprotein IIb/IIIa receptor, aggregation, fibrinogen bridges, aggregated platelets
aggregation complex process fibrinogen bridges glycoprotein IIb/IIIa receptor aggregated platelets Unstable
STAGE ONE- Formation of platelet plug fill in blank! CON
What complex process is formed during Aggregation?
complex process, glycoprotein IIb/IIIa receptor, aggregation, fibrinogen bridges, aggregated platelets
fibrinogen bridges
STAGE TWO- Coagulation
Defined as production of ?
- Done by two pathways
- ? (contact/surface activation pathway)
- ? (tissue factor pathway)
- Both ultimately converge at ?
Intrinsic, fibrin (I), Factor Xa, Extrinsic
fibrin (I)
Intrinsic
Extrinsic
Factor Xa
STAGE TWO- Coagulation
What is the production of Coagulation define as ?
Intrinsic, fibrin (I), Factor Xa, Extrinsic
fibrin (I)
STAGE TWO- Coagulation
Which contact/surface activation pathway?
Intrinsic, fibrin (I), Factor Xa, Extrinsic
Intrinsic
STAGE TWO- Coagulation
Which is tissue factor pathway
Intrinsic, fibrin (I), Factor Xa, Extrinsic
Extrinsic
STAGE TWO- Coagulation
Where do Intrinsic and Extrinsic converge at
Intrinsic, fibrin (I), Factor Xa, Extrinsic
Factor Xa—-10a
STAGE TWO- Coagulation
What is the final result of both Intrinsic and Extrinsic pathways
fibrin (I), Factor Xa, fibrin
fibrin
Hemostasis/Coagulation
Which is an enzyme that causes a blood clotting factor?
plasminogen, von Willebrand Factor, thromboplastin, prostacyclin, proteins C & S
thromboplastin
Hemostasis/Coagulation
Which is an enzyme that causes dissolution of fibrin blood clots.
plasminogen, von Willebrand Factor, thromboplastin, prostacyclin, proteins C & S
plasminogen
Hemostasis/Coagulation
Which is a lipid molecules that inhibits platelet activation and is also an effective vasodilator.
plasminogen, von Willebrand Factor, thromboplastin, prostacyclin, proteins C & S
prostacyclin
Hemostasis/Coagulation
Which is a blood glycoprotein involved in hemostasis.
plasminogen, von Willebrand Factor, thromboplastin, prostacyclin, proteins C & S
von Willebrand Factor
Hemostasis/Coagulation
Which regulates blood clotting?
plasminogen, von Willebrand Factor, thromboplastin, prostacyclin, proteins C & S
Proteins C & S
Hemostasis/Coagulation
Which of the following promotes the above?
a. Platelets
b. Prostacyclin
c. von Willebrand Factor
d. anti-thrombin III,
e. activated clotting factors
f. Proteins C & S,
g. plasmin(plasminogen)
h. thromboplastin
i. TXA2
j. ADP
a. Platelets
c. von Willebrand Factor
e. activated clotting factors
h. thromboplastin
i. TXA2
j. ADP
Hemostasis/Coagulation
Which of the following inhibits the above?
a. Platelets
b. Prostacyclin
c. von Willebrand Factor
d. anti-thrombin III
e. activated clotting factors
f. Proteins C & S,
g. plasmin(plasminogen)
h. thromboplastin
i. TXA2
j. ADP
b. Prostacyclin
d. anti-thrombin III
f. Proteins C & S
g. plasmin(plasminogen)
Which is an irregular and often rapid heart rate that occurs when the two upper chambers of your heart experience chaotic electrical signals.
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
Atrial Fibrillation
is a sudden blockage of blood clot that break loose and travels through the bloodstream to the lungs in a lung artery.
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
Pulmonary embolism
Which is an obstruction of an artery by blood clots/
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
Embolism
Which is a blood clot formed in within the vascular system (Veins and Arteries)
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
Thrombus
Which of is when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs.
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
DVT
Which of the following means action taken to prevent diseases?
Pulmonary embolism, DVT, Thrombus, Atrial Fibrillation, Embolism, Prophylaxis
Prophylaxis
Hemostasis/Coagulation
What disease states are we concerned about? ?-state why.
a. DVT Prophylaxis
b. Travelling
c. Pregnancy
d. Cancer
e. Atrial Fibrillation-
f. Mechanical heart Valve
g. All
Hypercoagulable, Hospitalized/immobile, Stroke
All
a. Hospitalized/immobile
b. c. Hypercoagulable
e. Stroke
Hemostasis/Coagulation
What complications from these disease states can arise?
a. Blood clot
b. Thrombus
c. Ulcers
d. Embolism
e. Toxics
f. Pulmonary embolism
g. DVT
a. Blood clot
b. Thrombus
d. Embolism
f. Pulmonary embolism
g. DVT
Coagulation Modifier Drugs
Which is an Antithrombotic drugs?
Antiplatelet drugs- ,Anticoagulants, Thrombolytic drugs
Anticoagulants
Coagulation Modifier Drugs
Which is DVT/PE prevention/treatment ?
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Anticoagulants/Antithrombotic drugs
Coagulation Modifier Drugs
Which inhibit platelet aggregation
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Antiplatelet drugs
Coagulation Modifier Drugs Which Lyse (break down) existing clots
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Thrombolytic drugs
Coagulation Modifier Drugs
Which Inhibit the action or formation of clotting factors
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Anticoagulants/Antithrombotic drugs
Coagulation Modifier Drugs
Which Prevents platelet plugs
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Antiplatelet drugs
Coagulation Modifier Drugs
Which Prevents clot formation
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Anticoagulants/Antithrombotic drugs
Coagulation Modifier Drugs
Which drug deals with coronary arteries- ARTERIES
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Antiplatelet drugs
Coagulation Modifier Drugs
Which drug deals with the veins
Antiplatelet drugs- , Anticoagulants/Antithrombotic drugs, Thrombolytic drugs
Anticoagulants/Antithrombotic drugs
NOAC/DOACs what does this mean
a. Novas oral anticoagulants
b. Novel oral anticoagulants
c. Dispensed oral anticoagulants
d. Direct oral anticoagulants
b. Novel oral anticoagulants
d. Direct oral anticoagulants
Anticoagulants Drugs
Which are ORAL?
Heparin Type Products, Vitamin K Antagonists, Non-Heparin Products, NOAC/DOACs
Vitamin K Antagonists
NOAC/DOACs
Anticoagulants Drugs
Which are PARENTERAL?
Heparin Type Products, Vitamin K Antagonists, Non-Heparin Products, NOAC/DOACs
Heparin Type Products
Non-Heparin Products
Anticoagulants Drugs
Which are Heparin Type Products
a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran
b. Heparin
e. Enoxaparin
Anticoagulants Drugs
Which are non Heparin Type Products
a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran
g. Argatroban
Anticoagulants Drugs
Which are Vitamin K Antagonists
a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran
f. Warfarin
Anticoagulants Drugs
Which are NOAC/DOACs
a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran
a. Apixaban
c. Rivaroxaban
h. Dabigatran