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Pharmocology > Coagulation Modifying Agents Part 2: > Flashcards

Coagulation Modifying Agents Part 2: Flashcards

1
Q

is the following drugs use for Anti-platelets or Anticoagulant drugs?
Aspirin
Clopidogrel

A

Anti-platelets

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2
Q

Which of the following are clotting factors?

a. Hgb
b. aPTT
c. INR
d. Plts
e. Hct
f. Pt

A

b. aPTT
c. INR
f. Pt

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3
Q

The following clotting factors deal with:
aPTT
INR
Pt

a. Platelets
b. Anti-coagulants

A

b. Anti-coagulants

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4
Q

aPTT?

Warfarin or Heparin

A

Heparin

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5
Q

INR?

Warfarin or Heparin

A

Warfarin

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6
Q

Pt?

Warfarin or Heparin

A

Warfarin

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7
Q

Which of the following inhibits/blocks factor 10a (Xa)?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

b. apixaban

c. rivaroxaban

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8
Q

Which of the following inhibits/blocks factor 2?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

d. dabigatran

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9
Q 
Which of the following does Warfarin inhibits/blocks?
a. Factor 2
b. Factor 3
c. Factor 7
d. Factor 8
e. Factor 9
f. Factor 10
G. Protein C & S
A

a. Factor 2
c. Factor 7
e. Factor 9
f. Factor 10
G. Protein C & S

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10
Q

Which of the following are Vitamin K Antagonist

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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11
Q

Which of the following is Coumadin

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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12
Q

Which of the following was the original rat killer?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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13
Q

Does A Fib (Atrial fibrillation) cause or prevent stokes?

A

It causes stokes

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14
Q

Do cancer patients have a higher risk of clotting?

Yes or No?

A

Yes

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15
Q

Which of the following -secondary prophylaxis/prevention,?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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16
Q

Which of the following - DVT/PE treatment?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

All

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17
Q

Which the following - A.fib ( stroke prevention)?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

All

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18
Q

Which of the following - DVT/PE treatment/prophylaxis?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

b. apixaban
c. rivaroxaban
d. dabigatran

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19
Q

Which is used - Cancer patients (higher risk for clotting)?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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20
Q

Which of the following Heart failure with a prseident 1955?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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21
Q

Which of the following treat - CS, unstable angina, MI, stroke?

A

?

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22
Q

The following are apart of which vitamin These factors are II, VII, IX, X and Protein C & S?

a. Vit C
b. Vit E
c. Vit K

A

c. Vit K

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23
Q

Which is the opposite of Vit K and inhibits factors are II, VII, IX, X and Protein C & S?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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24
Q

How do you check the effectiveness of Warfarin?

a. Hgb
b. aPTT
c. INR
d. Plts
e. Hct
f. Pt

A

c. INR

f. Pt

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25
Q

Baseline PT ? seconds?

A

11-12.5

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26
Q

Goal PT- ? seconds (? times the baseline)

A

18-24

1.5-2

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27
Q

Baseline INR ?

A

1

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28
Q

INR goal ? for Most Conditions

A

2-3

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29
Q

INR goal ? for Mechanical Heart Valves

A

2.5-3.5

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30
Q

Which of the following is instantaneous?

a. Warfarin
b. Heparin

A

b. Heparin

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31
Q

Which of the following is slow ?

a. Warfarin
b. Heparin

A

a. Warfarin

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32
Q

Warfarin take ? days to work

A

3 to 5

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33
Q

For any anticoagulant when patients fall and hit their heads, they are at risk for?

a. Nothing
b. Blindness
c. Intracranial hemorrhage

A

c. Intracranial hemorrhage

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34
Q

Even though Skin Necrosis is rare which anticoagulant causes it?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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35
Q

Which protein is a natural anticoagulant/

a. Protein L
b. Protein C
c. Protein S

A

b. Protein C

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36
Q

Which causes Warfarin to have an adverse side effect of Skin Necrosis?

a. Protein L
b. Protein C
c. Protein S
d. Cholesterol embolism

A

b. Protein C

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37
Q

Even though Purple Toe Syndrome is rare which anticoagulant causes it?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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38
Q

Which causes Warfarin to have an adverse side effect of Purple Toe Syndrome?

a. Protein L
b. Protein C
c. Protein S
d. Cholesterol embolism

A

d. Cholesterol embolism

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39
Q

Which drug has a Pregnancy Category X - CONTRAINDICATION!

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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40
Q

Vitamin K is the antidote for which drug?

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

a. Warfarin

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41
Q

If Vit. K is given to treat warfarin level what is it called as an IV

a. Phytonadione (Aquamephyton®)
b. Kcentra®-

A

a. Phytonadione (Aquamephyton®)

42
Q

Antibiotics- ( ? Vit K- ? effectiveness of warfarin)

a. More, Increase
b. More, Decrease
c. Less, Increase
d. Less, Decrease

A

c. Less, Increase

43
Q

Seizure medications big culprits are ? for Warfarin?

a. Inhibitor
b. Inducer

A

b. INDUCERS

44
Q

St. John’s Wort (herbal- anti-depressant) are ? for Warfarin?

a. Inhibitor
b. Inducer

A

b. INDUCER

45
Q

NSAIDs is the following ?

a. Aspirin
b. Acetaminophen
c. Ibuprofen

A

a. Aspirin

c. Ibuprofen

46
Q

Since NSAIDS causes bleeding risk which drug should you give a patient who is taking Warfarin?

a. Aspirin
b. Acetaminophen
c. Ibuprofen

A

b. Acetaminophen

47
Q

Which of the following will cause a bleeding risk for a patient taking warfarin? (Herbs)

a. Gingko biloba
b. Ginger
c. Garlic
d. Fish Oil
e. Feverfew
f. Saw Palmetto
g. St. Johns Wort

48
Q

Which of the following herbs decreases warfarin levels?

a. Gingko biloba
b. Ginger
c. Garlic
d. Fish Oil
e. Feverfew
f. Saw Palmetto
g. St. Johns Wort

A

g. St. Johns Wort

49
Q

Which should a patient do when taking warfarin?
a. Avoid vitamin K in diet
b. Limit vitamin K in diet but be consistent
c. Smoke
d Avoid Smoking
e. Drink Alcohol
F. Avoid Alcohol

A

b. Limit vitamin K in diet but be consistent
d Avoid Smoking
F. Avoid Alcohol

50
Q

Which of the flowing is true about Bridge Therapy?

a. You will give a patient heparin drip at (30-40 sec) until the patient warfarin level reach between 1-3 INR. Then you will take the patient off of heparin. (Take 3-5 days)
b. You will give a patient heparin drip at (60-80 sec) until the patient warfarin level reach between 2-3 INR. Then you will keep the patient on both heparin & warfarin. (Take 3-5 days)
c. You will give a patient heparin drip at (60-80 sec) until the patient warfarin level reach between 2-3 INR. Then you will take the patient off of heparin. (Take 3-5 days)

A

c. You will give a patient heparin drip at (60-80 sec) until the patient warfarin level reach between 2-3 INR. Then you will take the patient off of heparin. (Take 3-5 days)

51
Q

Bridge therapy cannot be use in reverse?

T/F. If not F why?

A

False
You can work slowly to take a patient off of warfarin by giving them heparin drip. Then use heparin only once warfarin level have reach base levels.

52
Q

Reflex tachycardia-
(rapid or slow) beating of the heart, is an (increased or decreased) heart rate in response to the stimulus of (increased or decreased) blood pressure

A

rapid
increased
decreased

53
Q

Reflex bradycardia-
(rapid or slow) beating of the heart, is an (increased or decreased) heart rate in response to the stimulus of (increased or decreased) blood pressure

A

slow
decreased
increased

54
Q

Which is caused by taking warfarin?

a. Reflex bradycardia
b. Reflex tachycardia

A

b. Reflex tachycardia

55
Q

if a patient decides to take rivaroxaban, apixaban, or Dabigatran which of the following is true?

a. INR checked weekly
b. INR isn’t checked
c. Vitamin K issue and Vit. K diet needed
d. No Vitamin K issue and Vit. K diet needed
e. Herbals issues
f. No Herbals issues

A

b. INR isn’t checked
d. No Vitamin K issue and Vit. K diet needed
e. Herbals issues

56
Q

Which is a Novel/NEW Oral Anticoagulants (NOACs)

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

b. apixaban

c. rivaroxaban

57
Q

Which is a Direct Oral Anticoagulants (DOACs)

a. Warfarin
b. apixaban
c. rivaroxaban
d. dabigatran

A

d. dabigatran

58
Q

Which anticoagulants do you avoid using with other anticoagulants

a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran

A

a. Apixaban
c. Rivaroxaban
h. Dabigatran

59
Q

Which drugs you have to be consistent with and not miss a dose? Is it true that if you miss a dose the drug will drop allot in your body? T/F

a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran

A

a. Apixaban
c. Rivaroxaban
h. Dabigatran

True

60
Q

Which drug has this antedote Andexxa® /Andexanet alfa?

a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran

A

a. Apixaban

c. Rivaroxaban

61
Q

Which has this antedote Praxbind® (Idarucizumab)

a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran

A

h. Dabigatran

62
Q

Must be given with full glass of water. If GI upset occurs even with full glass of water, can give with meals. Which drug?

a. Apixaban
b. Heparin
c. Rivaroxaban
e. Enoxaparin
f. Warfarin
g. Argatroban
h. Dabigatran

A

h. Dabigatran

63
Q

Which are the following is safe to use with Warfarin?

a. Grape Juice
b. Cranberry Juice

A

b. Cranberry Juice

64
Q

Which antiplatelets drugs are The Originals?

a. Clopidogrel
b. Aspirin
c. Ticagrelor

A

b. Aspirin

65
Q

Which antiplatelets drugs are The P2Y12 ADP Receptor Antagonists?

a. Clopidogrel
b. Aspirin
c. Ticagrelor

A

a. Clopidogrel

c. Ticagrelor

66
Q

Which of the following drugs: Work on preventing platelet aggregation?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

c. Ticagrelor
d. Clopidogrel
e. Aspirin

67
Q

The following drugs stop which option?

c. Ticagrelor
d. Clopidogrel
e. Aspirin

Arterial thrombosis vs Venous thrombosis

A

Arterial thrombosis

68
Q

Which drug stops Arterial thrombosis

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

c. Ticagrelor
d. Clopidogrel
e. Aspirin

69
Q 
Which drug is mostly used for 
Coronary Stenting
Acute MI
a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
A

e. Aspirin

70
Q

Which drug used for pediatrics with Kawasaki only!

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

e. Aspirin

71
Q

The cyclooxygenase pathway (COX I and COX II) starts (activation or aggregation) for platelets?

A

aggregation

72
Q

Which drug Prevents synthesis and release of prostaglandins by interrupting the cyclooxygenase pathway (COX I and COX II) from starting aggregation for platelets?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

e. Aspirin

73
Q

Aspirin effects on cyclooxygenase pathway (COX I and COX II) is ( reversible or irreversible) for plts~(4,5,6, or 7 days)

A

irreversible

7

74
Q

Which is a condition that occurs when the lungs cannot remove all of the carbon dioxide the body produces

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy

A

b. Respiratory acidosis

75
Q

This occurs when you breathe too fast or too deep and carbon dioxide levels drop too low?

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy

A

a. Respiratory alkalosis

76
Q

Which has this effect ringing in the ears, nausea, and vomiting?

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy
h. Reye’s syndrome

A

c. Salicylism

77
Q

This is a condition which you start to breathe very fast

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy
h. Reye’s syndrome

A

Hyperventilation

78
Q

Which is a disease of the kidneys caused by damage to the small blood vessels or to the units in the kidneys

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy
h. Reye’s syndrome

A

Nephropathy

79
Q

Which is a persistent opening between the two major blood vessels leading from the heart. This is suppose to close after birth but opens again?

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy
h. Reye’s syndrome

A

d. Patent ductus arteriosus (PDA)

80
Q

This is a rare but serious condition that causes confusion, swelling in the brain, and liver damage in children. This condition is why children should not take aspirin.

a. Respiratory alkalosis
b. Respiratory acidosis
c. Salicylism
d. Patent ductus arteriosus (PDA)
e. Hyperventilation
f. Nephropathy
h. Reye’s syndrome

A

h. Reye’s syndrome

81
Q

Which of the following is Adverse side effect of Aspirin?

a. Asthma
b. Salicylism (N/V/D)
c. Rapid breathing
d. Slow Breathing
e. Hyperventilation
f. Hypoventilation
g. Premature closing of PDA
h. Platelet disaggregation
i. Peptic Ulcer Disease
j. Intestinal bleeding
k. Reye’s Syndrome
l. Ringing in the ears
m. Renal Impairment
n. Rapid Breathing
o. RESPIRATORY ALKALOSIS
p. RESPIRATORY ACIDOSIS
q. Noise (Tinnitus)
r. Nephropathy
s. Hepatic

A

a. Asthma
b. Salicylism (N/V/D)
c. Rapid breathing
e. Hyperventilation
g. Premature closing of PDA
h. Platelet disaggregation
i. Peptic Ulcer Disease
j. Intestinal bleeding
k. Reye’s Syndrome
l. Ringing in the ears
m. Renal Impairment
n. Rapid Breathing
o. RESPIRATORY ALKALOSIS
q. Noise (Tinnitus)
r. Nephropathy

82
Q

Which of the following will cause GI upsets beside aspirin?

a. Smoking
b. Alcohol
c. Corticosteroids
d. NSaids
e. Ibuprofen
f. Acetaminophen
g. Tylenol

A

a. Smoking
b. Alcohol
c. Corticosteroids
d. NSaids
e. Ibuprofen

83
Q

Do decrease GI upset a Patients can use ?

a. an enteric coated table
b. an enteric non- coated tablet
c. take with food or water/milk
d. Take on an empty stomach

A

a. an enteric coated table

c. take with food or water/milk

84
Q

Which can a child cannot have?

a. Pepto Bismol Calcium Carbonate Anticid
b. Pepto Bismol Bismuth Subsalicylate

A

b. Pepto Bismol Bismuth Subsalicylate

85
Q 
Which of the following drugs 
Percutaneous Coronary Intervention (STENT placement)
Ischemic Stroke?
a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
A

c. Ticagrelor

d. Clopidogrel

86
Q

Which drugs Block P2Y12 ADP receptors on platelets which prevents ADP stimulated aggregation

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

c. Ticagrelor

d. Clopidogrel

87
Q

Percutaneous Coronary Intervention (PCI ) uses DAPT= Dual Anti-Platelet Therapy with which following drugs?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

e. Aspirin + c. Ticagrelor

e. Aspirin + d. Clopidogrel

88
Q

Which stop platelets from forming once stent is removed?

a. APT= Anti-Platelet Therapy
b. DAPT= Dual Anti-Platelet Therapy

A

b. DAPT= Dual Anti-Platelet Therapy

89
Q

DAPT= Dual Anti-Platelet Therapy which are you on for a year?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban

A

c. Ticagrelor

d. Clopidogrel

90
Q

DAPT= Dual Anti-Platelet Therapy which are you on for a res of your life?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator

A

e. Aspirin

91
Q

Aherence is important for which drugs?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator

A

c. Ticagrelor

d. Clopidogrel

92
Q

Does Thrombolytic Therapy (Tissue Plasminogen Activator ) inhibit the growth of clots or is it a clot buster?

A

clot buster

93
Q

Which is given treats Ischemic Stroke–Massive Pulmonary Embolism–Massive Myocardial Infarction–Central venous catheter clearance (tiny dose)

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator

A

h. Tissue Plasminogen Activator

94
Q

Alteplase “plase is what drug?

a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator

A

h. Tissue Plasminogen Activator

95
Q

for Tissue Plasminogen Activator- Alteplase “plase

Most STROKE guidelines allow within ? hours of symptom ONSET

96
Q 
Binds to plasminogen- forms a complex which causes conversion to plasmin
Plasmin digests the fibrin meshwork of clots (Factor 1)
a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator
A

h. Tissue Plasminogen Activator

97
Q 
Which can cause 
Death (ASSENT-2 trial ) 30 days ,6.2%
Major Hemorrhage at 30 days, 5.9%
a. Apixaban
b. Heparin
c. Ticagrelor
d. Clopidogrel
e. Aspirin
f. Warfarin
g. Argatroban
h. Tissue Plasminogen Activator
A

h. Tissue Plasminogen Activator

98
Q

DO NOT GIVE ANY ANTICOAGULANTS/ANTIPLATELETS FOR ? HOURS AFTER RECEIVING Tissue Plasminogen Activator

99
Q

If a patient is taking anticoagulant med can they take Tissue Plasminogen Activator?
Yes/NO

100
Q

When giving enipunctures and subcutaneous/IM injections on patient taking Alteplase (TPA) you should Hold direct pressure to injection site or ABG site for up to ? min until oozing stops

101
Q

With a stoke TIME IS BRAIN- 2 million neurons die each ? ?, these do not rejuvenate

Pharmocology (36 decks)

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