Pain Part 3 (Gout).pptx Flashcards
Which of the following are GOUT Drugs
a. Colchicine
b. Febuxostat
c. Allopurinol
d. Sumatriptain
e. Ergotamine
f. Probenecid
a. Colchicine
b. Febuxostat
c. Allopurinol
f. Probenecid
Fill in the blank ? the uric acid
CAP
Which means simply excessive uric acid that forms uric acid crystals in joints and tissue?
a. arthritis
b. gout
b. gout
What are the two main causes for gout?
a. Under-excretion - Kidneys
b. Under-excretion- Tumor Lysis Syndrome/ Diet induced-/ Excessive purines (hypoxanthine)
c. Over production- Tumor Lysis Syndrome/ Diet induced-/ Excessive purines (hypoxanthine)
d. Over production- Kidneys
a. Under-excretion - Kidneys
Over production- Tumor Lysis Syndrome/ Diet induced-/ Excessive purines (hypoxanthine)
What treat Gout and Uric acid?
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
All
Which treats Chronic Gout
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
d. Allopurinol
f. Febuxostat
Which treat acute gout
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
b. IV Corticosteroids
Which Inhibit Xanthine oxidase- this is needed to make uric acid. End result- less uric acid
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
d. Allopurinol
f. Febuxostat
Which has Hypersensitivity Reactions (SJS/TEN)
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
d. Allopurinol
f. Febuxostat
Which is Symptoms of Allopurinol Skin Rash Fever Lips peeling Mouth sores Sore throat Fatigue
All
Which can be used for Tumor Lysis Syndrome
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
d. Allopurinol
Which Deals with Higher risk of CV (Cardiovascularevents) a. NSAIDS b. IV Corticosteroids c. Colchicine d. Allopurinol e. Probenecid f. Febuxostat
f. Febuxostat
Which treat Acute Gout (Gout Flare Ups)
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
c. Colchicine
Which Stops microtubules of WBCs, therefore stops WBCs from entering joints and attack gout crystals. If WBCs attack joints, they further increase inflammation
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
c. Colchicine
Which is Chronic Gout
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
e. Probenecid
ADVERSE EFFECTS:◦May target microtubules of our own rapidly multiplying cells. Early warning of this is GI symptoms, late warning is systemic organ damage- Death
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
c. Colchicine
Which Adverse Alters urine- so kidney stones, kidney injuries
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
e. Probenecid
Which Patients will be on this daily
a. NSAIDS
b. IV Corticosteroids
c. Colchicine
d. Allopurinol
e. Probenecid
f. Febuxostat
d. Allopurinol
e. Probenecid
Promotion of Migraine
a. CGRP (calcitonin gene related peptide)
b. Serotonin (5-HT)
a. CGRP (calcitonin gene related peptide)
Inhibition of Migraine
a. CGRP (calcitonin gene related peptide)
b. Serotonin (5-HT)
b. Serotonin (5-HT)
Which Aborting an ongoing migraine attack to relieve headache and associated symptoms?
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
WHich is b. Serotonin (5-HT)
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
WHich is b. Serotonin (5-HT)
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
Which cause Chest pain?
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
Which Avoid in CAD, HTN, hx of MI, or other heart disease
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
Which Avoid in pregnancy
a. Sumatriptain- “Triptans”
b. Ergotamine
a. Sumatriptain- “Triptans”
Which should a patient avoid with Sumatriptain Emotions Certain Drugs Lights/Noises Certain Foods (besides Tyramine)
aall
Sumatriptain should work orally with in ? min
and can be repeated in ? hours
1 min
1 -2
Which Treat or abort an oncoming migraine
a. Sumatriptain- “Triptans”
b. Ergotamine
b. Ergotamine
Which Causes vasoconstriction of cranial blood vessels
a. Sumatriptain- “Triptans”
b. Ergotamine
b. Ergotamine
Do NOT give Ergotamine within ? hours of a triptan- the two together can cause extreme vasospastic reaction
24
Ergotamine Adverse side effects
a. Physical Dependence (can have withdrawal- HA,N/V)
b. GI- N/V/D- give with food
c. Toxicity: Called Ergotism
d. Convulsions- seizures/spasms, muscle pain
e. Hallucinations- CNS
f. Extreme vasoconstriction to extremities (dry gangrene)
All
