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Pharmocology > HIV ANTI-VIRAL DRUGS > Flashcards

HIV ANTI-VIRAL DRUGS Flashcards

1
Q

Hiv is a

RNA virus, specifically retroviral or DNA virus, specifically retroviral

A

RNA virus, specifically retroviral

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2
Q

Does HIV does or doesn’t Target CD4 Helper T Cells

A

Does

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3
Q 
?- Antiretroviral therapy
?- highly active antiretroviral therapy•contains at least three antivirals
?- combination antiretroviral therapy
? “Pre-Exposure Prophylaxis”
?PEP “Post Exposure Prophylaxis”

HAART, PEP, PrEP, ART, or cART

A 
ART
HAART
cART
PrEP
PEP
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4
Q

HIV prevalence rates in urban poverty areas did or did not differ significantly by race or ethnicity

A

did

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5
Q

Poverty increases the risk of HIV by 10, 15, or 20%.

A

20%

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6
Q

Which drug is a Fusion/Entry Inhibitors (stop hiv)

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Enfuvirtide

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7
Q

What is the plan in order to stop new HIV infections

Treat, Diagnose, Respond, Prevent

A

Diagnose
Treat
Prevent
Respond

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8
Q

Which drug has an adverse side effect of
soreness at the injection site
Pneumonia

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Enfuvirtide

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9
Q

NURSING ACTIONS:
This is a unique subcutaneous injectable
•Reconstitute inject (sterile water or Normal saline) into vial
•(Rigously Or Gently) roll the vial
•Make sure solution (looks clear with no particulate or does not need to be clear with particulate)- may take some time
•Bring to freezing or room temperature

A

Sterile water
Gently
looks clear with no particulate
Room

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10
Q

CCR5 Antagonist which also block HIV Fusion

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Maraviroc

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11
Q 
Which drug has adverse side effects of 
Hepatotoxicity
Upper Respiratory Tract Infections
Musculoskeletal Pain
CNS- dizziness

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Maraviroc

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12
Q

Which drug Nucleoside Reverse Transcriptase Inhibitor (NRTI’s )- which suppresses viral DNA synthesis by preventing reverse transcriptase

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Zidovudine

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13
Q

Which drug is used to prevent pregnant women from trasmitting hiv to an unborn baby

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Zidovudine

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14
Q

Which drug has an adverse side effect of
Major Concern is BONE MARROW SUPPRESSION (pancytopenia!)
Hepatomegaly/Fatty Liver
Lactic Acidosis

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Zidovudine

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15
Q

Is a condition that occurs when a person has low counts for all three types of blood cells: red blood cells, white blood cells, and platelets.

neutropenia or pancytopenia

A

pancytopenia

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16
Q

Which drug cause pancytopenia as an adverse side effect.

Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz

A

Zidovudine

17
Q

bind and inhibit HIV protease

protease inhibitors or integrase inhibitors or NNRTIs

A

protease inhibitors

18
Q

bind and inhibit HIV integraseprevents viral DNA integrating in to host chromosome

protease inhibitors or integrase inhibitors or NNRTIs

A

integrase inhibitors

19
Q 
ADVERSE EFFECT of which drug
hyperglycemia 
elevated triglycerides
Lipodystrophy
Elevated LFTs
Bone loss/Osteoporosis

protease inhibitors or integrase inhibitors or NNRTIs

A

protease inhibitors

20
Q

ADVERSE EFFECT of which drug
Rash- SJS/TEN!
Hepatotoxicity

protease inhibitors or integrase inhibitors or NNRTIs

A

integrase inhibitors

21
Q

Which drug binds to the active center of reverse transcriptase, thereby causing direct inhibition

protease inhibitors or integrase inhibitors or NNRTIs

A

NNRTIs

22
Q

Which drug has a adverse side effect of
Rash
elevated liver enzymes

protease inhibitors or integrase inhibitors or NNRTIs

A

NNRTIs

23
Q

Which two drugs deal with Rashes

protease inhibitors or integrase inhibitors or NNRTIs

A

integrase inhibitors & NNRTIs

24
Q

ART or PrEP has 3 drugs

ART or PrEP has 2 drugs

A

3

2

25
Q

Which drugs is approved for use by FDA for everyone?

Truvada (tenofovir disoproxil fumarate and emtricitabine)
or
Descovy ® (tenofovir alafenamide and emtricitabine

A

Truvada

26
Q

Which drug is not approved for people assigned female at birth

Truvada (tenofovir disoproxil fumarate and emtricitabine)
or
Descovy ® (tenofovir alafenamide and emtricitabine

A

Descovy

27
Q

Emtracitibine + Tenofovir

Is used for Prep or HIV drugs

A

Prep

28
Q

Which drugs are Both drugs are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)

protease inhibitors or integrase inhibitors or NNRTIs or
Emtracitibine + Tenofovir

A

Emtracitibine + Tenofovir

29
Q

Which of the two drug cause
lactic acidosis
Hepatomegaly/Fatty Liver
Headache/ GI pain, weight loss

Emtracitibine + Tenofovir

A

Both

30
Q

Which of the two drugs cause
Bone Loss
Renal Impairment (caution with NSAIDs)

Emtracitibine + Tenofovir

A

Tenofovir

31
Q

Means taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent becoming infected.

PrEP or PEP

A

PEP

32
Q

Is adherence important for Prep?

A

Yes

33
Q

PEP can only be taken between 48 0r 72 hours after explosure

A

72

34
Q

Pep is taken once or for 28 days

A

28 days

35
Q

PEP is integrase inhibitors or NNRTIs

A

integrase inhibitors

36
Q

PrEP is integrase inhibitors or NNRTIs

A

NNRTIs

Pharmocology (36 decks)

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