HIV ANTI-VIRAL DRUGS Flashcards
Hiv is a
RNA virus, specifically retroviral or DNA virus, specifically retroviral
RNA virus, specifically retroviral
Does HIV does or doesn’t Target CD4 Helper T Cells
Does
?- Antiretroviral therapy ?- highly active antiretroviral therapy•contains at least three antivirals ?- combination antiretroviral therapy ? “Pre-Exposure Prophylaxis” ?PEP “Post Exposure Prophylaxis”
HAART, PEP, PrEP, ART, or cART
ART HAART cART PrEP PEP
HIV prevalence rates in urban poverty areas did or did not differ significantly by race or ethnicity
did
Poverty increases the risk of HIV by 10, 15, or 20%.
20%
Which drug is a Fusion/Entry Inhibitors (stop hiv)
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Enfuvirtide
What is the plan in order to stop new HIV infections
Treat, Diagnose, Respond, Prevent
Diagnose
Treat
Prevent
Respond
Which drug has an adverse side effect of
soreness at the injection site
Pneumonia
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Enfuvirtide
NURSING ACTIONS:
This is a unique subcutaneous injectable
•Reconstitute inject (sterile water or Normal saline) into vial
•(Rigously Or Gently) roll the vial
•Make sure solution (looks clear with no particulate or does not need to be clear with particulate)- may take some time
•Bring to freezing or room temperature
Sterile water
Gently
looks clear with no particulate
Room
CCR5 Antagonist which also block HIV Fusion
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Maraviroc
Which drug has adverse side effects of Hepatotoxicity Upper Respiratory Tract Infections Musculoskeletal Pain CNS- dizziness
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Maraviroc
Which drug Nucleoside Reverse Transcriptase Inhibitor (NRTI’s )- which suppresses viral DNA synthesis by preventing reverse transcriptase
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Zidovudine
Which drug is used to prevent pregnant women from trasmitting hiv to an unborn baby
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Zidovudine
Which drug has an adverse side effect of
Major Concern is BONE MARROW SUPPRESSION (pancytopenia!)
Hepatomegaly/Fatty Liver
Lactic Acidosis
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Zidovudine
Is a condition that occurs when a person has low counts for all three types of blood cells: red blood cells, white blood cells, and platelets.
neutropenia or pancytopenia
pancytopenia
Which drug cause pancytopenia as an adverse side effect.
Maraviroc, Enfuvirtide, Zidovudine, Delavirdine, Efavirenz
Zidovudine
bind and inhibit HIV protease
protease inhibitors or integrase inhibitors or NNRTIs
protease inhibitors
bind and inhibit HIV integraseprevents viral DNA integrating in to host chromosome
protease inhibitors or integrase inhibitors or NNRTIs
integrase inhibitors
ADVERSE EFFECT of which drug hyperglycemia elevated triglycerides Lipodystrophy Elevated LFTs Bone loss/Osteoporosis
protease inhibitors or integrase inhibitors or NNRTIs
protease inhibitors
ADVERSE EFFECT of which drug
Rash- SJS/TEN!
Hepatotoxicity
protease inhibitors or integrase inhibitors or NNRTIs
integrase inhibitors
Which drug binds to the active center of reverse transcriptase, thereby causing direct inhibition
protease inhibitors or integrase inhibitors or NNRTIs
NNRTIs
Which drug has a adverse side effect of
Rash
elevated liver enzymes
protease inhibitors or integrase inhibitors or NNRTIs
NNRTIs
Which two drugs deal with Rashes
protease inhibitors or integrase inhibitors or NNRTIs
integrase inhibitors & NNRTIs
ART or PrEP has 3 drugs
ART or PrEP has 2 drugs
3
2
Which drugs is approved for use by FDA for everyone?
Truvada (tenofovir disoproxil fumarate and emtricitabine)
or
Descovy ® (tenofovir alafenamide and emtricitabine
Truvada
Which drug is not approved for people assigned female at birth
Truvada (tenofovir disoproxil fumarate and emtricitabine)
or
Descovy ® (tenofovir alafenamide and emtricitabine
Descovy
Emtracitibine + Tenofovir
Is used for Prep or HIV drugs
Prep
Which drugs are Both drugs are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)
protease inhibitors or integrase inhibitors or NNRTIs or
Emtracitibine + Tenofovir
Emtracitibine + Tenofovir
Which of the two drug cause
lactic acidosis
Hepatomegaly/Fatty Liver
Headache/ GI pain, weight loss
Emtracitibine + Tenofovir
Both
Which of the two drugs cause
Bone Loss
Renal Impairment (caution with NSAIDs)
Emtracitibine + Tenofovir
Tenofovir
Means taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent becoming infected.
PrEP or PEP
PEP
Is adherence important for Prep?
Yes
PEP can only be taken between 48 0r 72 hours after explosure
72
Pep is taken once or for 28 days
28 days
PEP is integrase inhibitors or NNRTIs
integrase inhibitors
PrEP is integrase inhibitors or NNRTIs
NNRTIs
