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Pharmocology > Endocrine Part 3-Thyroid.ppt > Flashcards

Endocrine Part 3-Thyroid.ppt Flashcards

1
Q

Drugs to treat HYPOTHYROIDISM

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

a. Levothyroxine
c. Liothyronine
e. Desiccated thyroid

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2
Q

Drugs to treat HYPERTHYROIDISM/ Anti-Thyroid Drugs

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

b. Methimazole

d. Propylthiouracil (PTU)

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3
Q

This occurs when your thyroid gland produces too much of the hormone thyroxine?

a. Euthyroid
b. Hypothyroidism
c. Hyperthyroidism
d. Thyroid Stimulating Hormone (TSH)
e. Thyroxine (T4)
f. Triiodothyronine (T3)

A

c. Hyperthyroidism

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4
Q

This is when the thyroid gland does not produce enough thyroid hormones to meet the needs of the body?

a. Euthyroid
b. Hypothyroidism
c. Hyperthyroidism
d. Thyroid Stimulating Hormone (TSH)
e. Thyroxine (T4)
f. Triiodothyronine (T3)

A

b. Hypothyroidism

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5
Q

This is having a normally functioning thyroid gland.

a. Euthyroid
b. Hypothyroidism
c. Hyperthyroidism
d. Thyroid Stimulating Hormone (TSH)
e. Thyroxine (T4)
f. Triiodothyronine (T3)

A

a. Euthyroid

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6
Q 
With Thyroxine (T4) and Triiodothyronine (T3), what do the 3 and 4 mean
Number of ?
a. Calcium
b. Glucose
c. Iodine
A

c. Iodine

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7
Q

Think Thyroid Hormone like ? , but helps you grow and mature.

a. Epinephrine
b. Adrenaline

A

Adrenaline

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8
Q

Thyroxine (T4)

a. Longer half life ~ 7 days
b. Shorter half life ~ 1 day
c. Potent (3-4 times more potent than other
d. Pro-hormone (low potency)

A

a. Longer half life ~ 7 days

d. Pro-hormone (low potency)

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9
Q

Triiodothyronine (T3)

a. Longer half life ~ 7 days
b. Shorter half life ~ 1 day
c. Potent (3-4 times more potent than other
d. Pro-hormone (low potency)

A

b. Shorter half life ~ 1 day

c. Potent (3-4 times more potent than other

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10
Q 
1 Which covert ? in the body?
2 And which of them would you give a Hypothyroidism?
3 Which is an higher ratio?
a. Triiodothyronine (T3)
b. Thyroxine (T4)
A

1 b. Thyroxine (T4) - a. Triiodothyronine (T3)

2 b. Thyroxine (T4)

3 2 b. Thyroxine (T4)

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11
Q

Which is the gold standard for test Thyroid Levels/

a. Triiodothyronine (T3)
b. Thyroxine (T4)
c. Thyroid Stimulating Hormone (TSH)

A

c. Thyroid Stimulating Hormone (TSH)

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12
Q

Thyroid Stimulating Hormone (TSH) ranges

? to ? milliunits/L per

A

0.3 to 5 milliunits/L per

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13
Q

Which is Hypothyroidism?

a. TSH= 0.2 milliunits/L
b. TSH= 10 milliunits/L

A

b. TSH= 10 milliunits/L

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14
Q

Which is Hyperthyroidism

a. TSH= 0.2 milliunits/L
b. TSH= 10 milliunits/L

A

a. TSH= 0.2 milliunits/L

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15
Q

Which drugs cause Hypothyroidism/

a. Levothyroxine
b. Lithium
c. Liothyronine
d. Amiodarone
e. Desiccated thyroid,

A

b. Lithium

d. Amiodarone

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16
Q

a lack of energy and enthusiasm?

a. Euphoria
b. Lethargy

A

b. Lethargy

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17
Q

Which is symptoms of Hypothyroidism?

a. Thickened skin
b. Hair loss
c. Diarrhea
d. Constipation
e. Euphoria
f. Lethargy
g. Weight gain
h. Tachycardia
i. Bradycardia
j. Sleepiness
k. Anorexia

A

a. Thickened skin
b. Hair loss
d. Constipation
f. Lethargy
g. Weight gain
i. Bradycardia
j. Sleepiness
k. anorexia

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18
Q

Thyroid drugs do not work the same way as endogenous thyroid hormones.
T/F, if not why?

A

False because they do

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19
Q

These drugs are used for the rest of the patient’s life.

T/F, if not why?

A

True

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20
Q

This is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related too slowing of function in multiple organs.

a. Angina
b. Myxedema coma

A

b. Myxedema coma

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21
Q

Which Treats all forms of hypothyroidism?

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

a. Levothyroxine

22
Q

Which treats Myxedema Coma?

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

a. Levothyroxine

23
Q

Which is simply synthetic T4 (thyroxine) & body will store and convert to T3 in ratios/

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

a. Levothyroxine

24
Q

A type of chest pain caused by reduced blood flow to the heart?

a. Angina
b. Myxedema coma

A

a. Angina

25
Q 
Levothyroxine (T4), Liothyronine (T3) and Desiccated Animal Thyroid (T4:T3 ratio)- Adverse Side effects
H
E
A
R
T
A 
H Heat intolerance
E Excitement (insomnia) 
A Angina
R Restless
T Tachycardia/Tremor
26
Q

FDA recommends not to use Levothyroxine (T4) as treatment for ?

a. Diabetes mellitus
b. Obesity/weight loss

A

b. Obesity/weight loss

27
Q

If you use Levothyroxine (T4) for Obesity/weight loss which are adverse side effects.

a. Dysrhythmia
b. Arrhythmia
c. Atrial fibrillation

A

a. Dysrhythmia

c. Atrial fibrillation

28
Q

Levothyroxine (T4)
ADMINISTRATION
1 This drug requires a/n (Full or Empty) stomach (acidic pH)
2 Give first thing in the (Morning or Afternoon)
Hospitals typically give around (0100 or 0600)

A

Empty
Morning
0600

29
Q

Levothyroxine (T4)
ADMINISTRATION
This drug can not have ? when being administrated/

A

Drug or food

30
Q

Levothyroxine (T4), why this is incorrect?

  1. Do administer with bile acid sequestrants (cholestyramine) separate by 1 hours
  2. Danger with other parasympathomimetic drugs
  3. Can decrease the effects of warfarin (bleeding risk!)
A
  1. Do not administer with bile acid sequestrants (cholestyramine) separate by 4 hours
  2. Danger with other sympathomimetic drugs (adrenaline)
  3. Can increase the effects of warfarin (bleeding risk!)
31
Q

Levothyroxine (T4)
Correct statements?
1. Educate patients that it will take two weeks to notice improvement (we generally check levels around 1-2 weeks after starting)

  1. Start with high dosage.
A
  1. Educate patients that it will take several weeks to notice improvement (we generally check levels around 4-6 weeks after starting)
  2. Start with low dosage.
32
Q

Levothyroxine (T4)
Correct statements?
1 This drug acts like a Acetylcholine- some patients report decreased alertness- imagine taking before bed

A

This drug acts like a catecholamine- some patients report increased alertness- imagine taking before bed

33
Q

Levothyroxine (T4) is or isn’t a NARROW THERAPEUTIC INDEX drug? (Is or Isn’t)

A

Is

34
Q

Whats true about Levothyroxine (T4)?

a. Narrow Therapeutic drug
b. Can switch between brands
c. Can not swish between brands
d. Can be swish with generic version of the same brand.

A

a. Narrow Therapeutic drug
c. Can not swish between brands
d. Can be swish with generic version of the same brand.

35
Q

Used when someone has an issue converting to T4 to T3

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

c. Liothyronine

36
Q

Used for hypothyroidism

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

e. Desiccated thyroid

37
Q

Some patients prefer a more “Natural” Route

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

e. Desiccated thyroid

38
Q

Not recommended by Leading Associations

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

e. Desiccated thyroid

39
Q

is an immune system disorder that results in the overproduction of thyroid hormones.

a. Thyroid storm
b. Graves’ disease

A

b. Graves’ disease

40
Q

is a life-threatening health condition that is associated with untreated or undertreated hyperthyroidism.

a. Thyroid storm
b. Graves’ disease

A

a. Thyroid storm

41
Q

Thyroid storm & Graves’ disease are

a. HYPERTHYROIDISM
b. HYPOTHYROIDISM

A

a. HYPERTHYROIDISM

42
Q

Is HYPERTHYROIDISM adverse side effects the same as Levothyroxine, Liothyronine, Desiccated thyroid - HEART?
Yes or No

A

Yes

43
Q

What does treat HYPERTHYROIDISM

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

b. Methimazole

d. Propylthiouracil (PTU)

44
Q

What are Methimazole + Propylthiouracil (PTU) what condition requires Beta-blocker?

a. Thyroid storm
b. Graves’ disease
c. HYPOTHYROIDISM

A

a. Thyroid storm

45
Q

Which drug prevents tyrosine from iodinating in the thyroid to create Thyroxine (T4) to Triiodothyronine (T3)

a. Levothyroxine
b. Methimazole
c. Liothyronine
d. Propylthiouracil (PTU)
e. Desiccated thyroid

A

b. Methimazole

d. Propylthiouracil (PTU)

46
Q

A rare, usually develops in first 2 months of therapy: fever, sore throat?

a. Kidney and Bone Marrow Suppression
b. Liver and Bone Marrow Suppression
c. High ALT AST
d. Low ALT AST
e. Hepatotoxicity
f. Nephrotoxicity
g. Agranulocytosis

A

g. Agranulocytosis

47
Q

What are Methimazole & Propylthiouracil (PTU) Adverse side effects

a. Kidney and Bone Marrow Suppression
b. Liver and Bone Marrow Suppression
c. High ALT AST
d. Low ALT AST
e. Hepatotoxicity
f. Nephrotoxicity
g. Agranulocytosis

A

b. Liver and Bone Marrow Suppression
c. High ALT AST
e. Hepatotoxicity
g. Agranulocytosis

48
Q

Patients on Antithyroid Drugs: Methimazole + PTU drugs should ? high iodine diet.

a. Keep
b. Avoid

A

b. Avoid

49
Q 
Example of food a patient with Methimazole + PTU drugs should avoid or limit?
a Seafood, 
b. Hot sauce
c. Beans
d. Soy sauce
e. Tofu 
f. Pepper
g. Iodized salt
A

a Seafood,

d. Soy sauce
e. Tofu
g. Iodized salt

50
Q

Which is true about Antithyroid Drugs: Methimazole + PTU ADMINISTRATION

a. Doesn’t need to be given with food
b. Better tolerated when given with food
c. Doesn’t need tp be given same time each day to maintain consistent blood levels.
d. Give at the same time each day to maintain consistent blood levels.
e. Never stop these medications abruptly.

A

b. Better tolerated when given with food
d. Give at the same time each day to maintain consistent blood levels.
e. Never stop these medications abruptly.

Pharmocology (36 decks)

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