PSYCH 104 Midterm 2 (The brain) Flashcards
Depolarization
Depolarization: the reduction of a membranes resting potential so that it is less negative (closer to zero)
Action potential
Action potential: electrical impulse that travels down the axon triggering the release of neurotransmitters
Repolarization
Repolarization: Na+ channels close, K+ channels open
Hyperpolarization
Hyperpolarization: the overshoot of repolarization
Refractory period:
Refractory period: the time at which it takes repolarization and hyperpolarization to occur
Postsynaptic potential (PSP)
Postsynaptic potential (PSP)
A voltage change at a receptor site on a postsynaptic cell membrane
Excitatory PSP
Excitatory PSP
○ A positive voltage shift that increases the likelihood that the postsynaptic neuron will fire action potentials (because it gets closer to the -55mV threshold)
Inhibitory PSP
Inhibitory PSP
○ A negative voltage shift that decreases the likelihood that the postsynaptic neuron will fire action potentials (because it gets further from the -55mV threshold)
Reuptake
Reuptake
○ Reobsorbtion of the neurotransmitter from the synaptic cleft by the presynaptic membrane
Amino acids
- Amino acids
§ Glutamate, GABA
Monoamines
Monoamines
○ Catecholamines
§ Dopamine
§ Norepinepherine
○ Indolamines
§ Serotonin
Acetylcholine
- Acetylcholine
○ Released by motor neurons
○ Contributes to the regulation of attention, arousal and memory
○ Nicotine stimulates Ach receptors
○ Memory enhancers increase ach
○ Insecticides block the breakdown of Ach creating excess amounts
○ Botox causes paralysis by blocking Ach
○ Alzheimer’s disease is associated with low levels of Ach
(is a small molecule neurotransmitter)
Unconventional neurotransmitters
- Unconventional neurotransmitters
○ Soluble gases
○ Endocannabinoids
§ Anandamide
Large molecule neurotransmitters
(What are they?)
Large molecule neurotransmitters
- Pituitary peptides
- Hypothalamic peptides
- Brain-glut peptides
- Opioid peptides
- Miscellaneous peptides
- Endorphins
- Dopamine’s (DA)
- Dopamine’s (DA)
○ Contributes to control of voluntary movement
○ Cocaine and amphetamines elevate activity in DA synapses
○ Dopamine circuits in medial forebrain bundle characterized as “reward pathway”
○ Degeneration of DA neurons is believed to be responsible for symptoms of Parkinson’s disease
- Serotonin (5-HT)
- Serotonin (5-HT)
○ Involved in regulation of sleep and wakefulness eating and aggression
○ Prozac and similar antidepressant drugs affect serotonin circuits
- Norepinepherine (NE)
- Norepinepherine (NE)
○ Brain arousal and other functions like mood, hunger, sleep, and sexual behavior
○ Drugs such as amphetamines and methamphetamines increase NE levels ○ Also known as nonamphetamine
- GABA
- GABA (ONLY INHIBITORY)
○ Gabba-aminobutyric acid
○ The brain’s main inhibitory transmitter
○ Contributes to regulation of anxiety and sleep/arousal
○ Contributes to regulation of anxiety and sleep/arousal
○ Valium and similar antianxiety drugs work at GABA synapses
Glutamate
- Glutamate
○ Main excitatory neurotransmitter in the nervous system participates in relay of sensory information and learning - an amino acid
Anandamide
- Anandamide
○ Binds to the same receptors as THC, the active ingredient in cannabis leaves
○ Comes from the Sanskrit word Ananda which means joy
○ Occurs in both the central and peripheral nervous system
○ Likely plays a role in eating, memory, motivation and sleep
CIPA
(CIPA: the ability to not feel pain)
Endorphins
- Endorphins (they work as a morphine and neurotransmitter)
○ More of these means less pain
○ Opposite is true
○ A naturally occuring analgesic
○ Inhibit the communication of pain signals to the spinal cord
○ Exercise causes more of these to appear
Neural plasticity
Neural plasticity: the ability for neural tissue to change and adapt over time
Neuroplasticity (Job in early development)
Job in early development:
1. Growth of dendrites and axons
2. Synaptogenesis
○ Formation of new synapses
3. Pruning
○ The removal of extra synapses to increase the efficiency of a neural network
○ Occurs until age ten
○ About 70% of neurons die off
4. Myelination: the insulation of axons
Neuroplasticity (Job in learning)
Job in learning:
- Long term potentiation of synapses
○ A long lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously
- Structural changes
○ Axonal growth
○ Dendritic branching / growth
Neuroplasticity (Jobs in injury)
Jobs in injury: (99% time damage is permanent)
- Brain regions can sometimes take over functions previously formed by others
- Researchers are searching for treatments to promote healing and prevent cell damage
○ Stem cell: a cell with the ability to specialize into any cell we need
- Neurogenesis: creation of new neurons