Proton Pump Inhibitors (-prazole)

Question 1

MOA

Answer 1

irreversibly inhibits H+/K+ - ATPase pump on parietal cell membrane which blocks final step in acid secretion into lumen of stomach

Question 2

primary purpose

Answer 2

• treat acid reflux and heal ulcers

- shown to be more effective than H2 receptor antagonists

Question 3

AEs

Answer 3

generally well-tolerated; long-term use associated with gastric polyps, altered calcium metabolism (decreased bone mineralization), some cardiovascular abnormalities

Question 4

drug names to know

Answer 4

• omeprazole (Prilosec)

- esomeprazole (Nexium)