Misc. Pulmonary Drugs

Question 1

leukotriene modifiers are used to treat ____

Answer 1

asthma

Question 2

leukotriene modifier MOA

Answer 2

competitively antagonize leukotriene receptors to reduce airway inflammation, edema, and smooth muscle contraction

Question 3

leukotriene modifier drug names to know

Answer 3

montelukast (Singulair)

Question 4

Anti-IgE MOA

Answer 4

binds IgE antibody and prevents it from binding to receptors, which limits the activation and release of allergic response mediators

Question 5

Anti-IgE drug names to know

Answer 5

omalizumab (Xolair)

Question 6

CFTR modulators MOA

Answer 6

keep the CFTR proteins open for longer or bring more proteins to the surface to help improve the transport of those ions and thus the transport of secretions/thinning of mucous

Question 7

CFTR modulator drugs to know

Answer 7

• Orkambi

- Symdeco

Question 8

CFTR modulator AEs

Answer 8

• HA, GI, respiratory

- Orkambi can cause dizziness or HTN

Question 9

CFTR modulators administration

Answer 9

• PO twice daily or twice weekly

- Must take with high fat meal to inc absorption

Question 10

Therapeutic concerns for anticholinergic drug tx in respiratory conditions

Answer 10

ABCDS

• tachycardia
• HTN
• Dry mouth

Question 11

Therapeutic concerns for steroids drug tx in respiratory conditions

Answer 11

• inhaled: oral candidiasis and thrush
• inc infection risk
• HTN
• hyperglycemia
• osteoporosis
• muscle weakness, skin atrophy

Question 12

Therapeutic concerns for B2-agonists drug tx in respiratory conditions

Answer 12

• tremor
• tachycardia
• hypokalemia
• hyperglycemia