Antivirals

Question 1

common AEs of antivirals

Answer 1

N/V/D, skin rash (SJS), myalgia, arthralgia, asthenia, tremors, seizures, delirium, insomnia, cardiac dysfunction

Question 2

HAART

Answer 2

• HIV treatment
• Combo therapy
• Biktarvy and Triumeq

Question 3

Hepatitis C tx (injections)

Answer 3

-Interferon and ribavirin (not liked or respond well)

Question 4

Hepatitis C tx (drugs)

Answer 4

• DAAs (direct-acting antivirals)
• fatigue, weakness, headache
• bradycardia when combined with amiodarone

Question 5

Is there a vaccine against Hepatitis C?

Answer 5

No, but there are vaccines against Hep A and Hep B

Question 6

Hepatitis B tx (injections)

Answer 6

• Interferon
• Weekly injection for 48 weeks
• Flu-like symptoms

Question 7

Hepatitis B tx (drugs)

Answer 7

• nuceloside
• PO
• Better tolerated than Interferon
• Entecavir, tenofovir disoproxil fumarate, tenofovir alafenamide

Question 8

Hepatitis A tx (vaccine)

Answer 8

• Immune globulin

- Boxed warning: thrombosis risk

Question 9

balaxavir (Xofluza)

Answer 9

• flu
• PO
• single dose
• diarrhea (only in 2% of people)

Question 10

oseltamivir (Tamiflu)

Answer 10

• flu
• PO
• nausea, vomiting, headache

Question 11

rehab concerns specific to antivirals

Answer 11

-Know the common AEs
-Know that antivirals can affect exercise tolerance
-Monitor pt exercise tolerance with vital signs
-Get pt feedback with Borg Rating of Perceived Exertion
and overall how s/he is feeling
-Avoid over-exerting the pt
-Use standard precautions during pt interactions