Ca Channel Blockers

Question 1

overall MOA of direct vasodilators

Answer 1

1. Act to directly vasodilate the peripheral vasculature

2. Act by inhibiting smooth muscle contraction in the arterioles → vasodilation

Question 2

overall AE of direct vasodilators

Answer 2

reflex tachycardia, dizziness, OH

Question 3

calcium channel blocker AE

Answer 3

HA, dizziness, hypotension, bradycardia, reflex tachycardia, sweating, tremor, flushing, constipation

Question 4

tell me about amlodipine

Answer 4

• calcium channel blocker
• belongs to the dihydropyridine class
• reduces arteriolar tone

Question 5

tell me about diltiazem

Answer 5

• calcium channel blocker
• belongs to the benzothiazepine class
• affects heart and vasculature

Question 6

MOA of calcium channel blockers

Answer 6

block Ca entrance into vascular smooth muscles, reducing smooth muscle tone

• dec contractility and CO
• dec cardiac fxn and energy demands on heart

Question 7

What are CCB used to treat?

Answer 7

HTN, angina, arrhythmia

Question 8

When are CCB a better choice than BB?

Answer 8

When BB are contraindicated due to DM, PVD, and asthma