Antifungals

Question 1

azoles

Answer 1

• Broad spectrum
• Fluconazole (PO, IV)
• Ketoconazole (PO)
• Some azoles are topical

*Common CYP interactions

Question 2

AEs of azoles

Hazel has nausea and a broken heart when she gets her period and keeps her room dark until it’s over

Answer 2

• N/V
• photophobia
• cardiac arrythmia
• menstrual irregularities
• DDI

Question 3

Nystatin

Nice Polly has cramps and wore a top that made her itch

Answer 3

• polyene
• PO = cramps, N/V/D
• Topical = rash, urticaria (hives)

Question 4

MOA for azoles and polyenes

Answer 4

alter cell membrane permeability

Question 5

rehab concerns for antifungals

Answer 5

• Tinea pedis (athlete’s foot)
• Tinea corporis (ringoworm)
• AIDS - compliance w lengthy tx
• parasitic infections