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Pharm (716) > Antiemetics > Flashcards

Antiemetics Flashcards

1
Q

anticholinergics are used to…

A

prevent motion-sickness related vomiting

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2
Q

anticholinergic MOA

A

binds to ACh receptors on vestibular nuclei, blocks communication

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3
Q

anticholinergic AEs

A

dizziness, drowsiness, dry mouth, blurred vision, dilated pupils, difficulty with urination

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4
Q

anticholinergic drug names to know

A

scopolamine (Transderm Scop patch)

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5
Q

antihistamines are used to…

A

prevent motion-sickness related vomiting

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6
Q

antihistamines MOA

A

inhibit vestibular input to the CTZ

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7
Q

antihistamines AEs

A

dizziness and sedation

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8
Q

antihistamine drug names to know

A

meclizine

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9
Q

neuroleptic drug MOA

A

block dopamine receptors in CTZ

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10
Q

neuroleptic drug AEs

A

OH, tachycardia, blurred vision, dry eyes, urinary retention, long-term use can lead to extrapyramidal symptoms, akinesia, tardive dyskinesia

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11
Q

prokinetic drug MOA

A
  • block dopamine in CTZ

- produce central and peripheral antiemetic effects

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12
Q

prokinetic drug AEs

A

sedation, diarrhea, weakness, prolactin release; prolonged use causes extrapyramidal signs, motor restlessness, hypo- and hypertension, tachycardia

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13
Q

prokinetic drug names to know

A

metoclopramide (for chemo-related vomiting)

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14
Q

serotonin blocker MOA

A
  • block serotonin receptors in GI tract, CTZ, and vomiting center
  • prevent vomiting (emesis)
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15
Q

serotonin blocker AEs

A

HA, dizziness, diarrhea

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16
Q

serotonin blocker drug names to know

A

ondansetron (Zofran)

17
Q

Neurokinin-1 receptor blockers MOA

A
  • block Substance P from binding to NK-1 receptor
  • prevents both central and peripheral stimulation of vomiting centers
  • good for addressing delayed emesis (common after cycles of chemo)
18
Q

Neurokinin-1 receptor blockers AEs

A

sedation, GI issues (diarrhea, constipation, gas, stomach pain, nausea), Stevens-Johnson syndrome

Pharm (716) (39 decks)

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