ARB (-sartan)

Question 1

overall MOA of ARB

Answer 1

• antagonist at AT1 (angiotensin II type 1) receptor = blocks binding of angiotensin II
• Results in ↓blood vessel vasoconstriction, ↓aldosterone release, and ↓constriction of the efferent arterioles

Question 2

ARB indication

Answer 2

Alternative if ACEi intolerant in HTN, kidney disease, heart failure, etc.

Question 3

ARB AE

Answer 3

similar to ACEi except no dry cough because it doesn’t stop angiotensin-II from being made, just stops it from binding

Question 4

ARB drug names to be familiar with

Answer 4

• Losartan

- Valsartan