Beta Blockers (-lol)

Question 1

overall MOA of beta blockers

Answer 1

• inhibit sympathetic activity -> reduce peripheral vascular resistance
• prevent normal ligand from binding to receptor by competing for the site
• decreases HR, contractility, & conduction

Question 2

beta blocker indication

Answer 2

• treat cardiovascular dysfunction: HTN, angina, arrhythmia, post-MI survival
• primarily administered for B1 antagonism of the heart

Question 3

non-selective beta blockers

Answer 3

• block β1- and β2-adrenoceptors

- ex: propranolol

Question 4

propranolol AE

Answer 4

• peripheral vasoconstriction, bronchoconstriction
• bradycardia -> heart block
• reduced exercise capacity/tolerance
• abrupt withdrawal of drug -> arrhythmia, angina, MI
• dizziness
• OH
• depression
• fatigue
• sexual dysfunction

Question 5

cardioselective beta blockers MOA and AE

Answer 5

• MOA: selectively block B1 receptors without causing bronchoconstriction
• AE: same as non-selective (except for pulmonary effects)

Question 6

cardioselective beta blocker drugs to know

Answer 6

• carvedilol

- metoprolol

Question 7

therapeutic concerns with beta blockers

Answer 7

• Depressed HR and CO during exercise
• May contribute to OH
• Watch for signs of CHF
• Masked symptoms of hypoglycemia in individuals with diabetes